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Special Collection: Molecular Imaging
2 Results
- Original Contribution
Influence of Repetitive Contrast Agent Injections on Functional and Molecular Ultrasound Measurements
Ultrasound in Medicine and BiologyVol. 40Issue 10p2468–2475Published online: July 9, 2014- Anne Rix
- Moritz Palmowski
- Felix Gremse
- Karin Palmowski
- Wiltrud Lederle
- Fabian Kiessling
- and others
Cited in Scopus: 14Quantitative contrast-enhanced ultrasound plays an important role in tumor characterization and treatment assessment. Besides established functional ultrasound techniques, ultrasound molecular imaging using microbubbles targeted to disease-associated markers is increasingly being applied in pre-clinical studies. Often, repeated injections of non-targeted or targeted microbubbles during the same imaging session are administered. However, the influence of repeated injections on the accuracy of the quantitative data is unclear. - Original Contribution
Effects of Acoustic Radiation Force on the Binding Efficiency of BR55, a VEGFR2-Specific Ultrasound Contrast Agent
Ultrasound in Medicine and BiologyVol. 38Issue 8p1460–1469Published online: May 14, 2012- Peter J.A. Frinking
- Isabelle Tardy
- Martine Théraulaz
- Marcel Arditi
- Jeffry Powers
- Sibylle Pochon
- and others
Cited in Scopus: 49This work describes an in vivo study analyzing the effect of acoustic radiation force (ARF) on the binding of BR55 VEGFR2-specific contrast-agent microbubbles in a model of prostatic adenocarcinoma in rat. A commercial ultrasound system was modified by implementing high duty-cycle 3.5-MHz center frequency ARF bursts in a scanning configuration. This enabled comparing the effects of ARF on binding in tumor and healthy tissue effectively in the same field of view. Bubble binding was established by measuring late-phase enhancement in amplitude modulation (AM) contrast-specific imaging mode (4 MHz, 150 kPa) 10 min after agent injection when the unbound bubbles were cleared from the circulation.