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    • Cover Image - Ultrasound in Medicine and Biology, Volume 49, Issue 5
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  • Original Contribution

    Lung Ultrasound Can Predict the Clinical Course and Severity of COVID-19 Disease

    Ultrasound in Medicine and Biology
    Vol. 47Issue 8p2090–2096Published online: May 3, 2021
    • Cecilia Gómez Ravetti
    • Paula Frizera Vassallo
    • Guilherme Monteiro de Barros
    • Guilherme Carvalho Rocha
    • Samuel Chamon
    • Isabela Nascimento Borges
    • and others
    Cited in Scopus: 4
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      Coronavirus disease 2019 (COVID-19) compromises the lung in large numbers of people. The development of minimally invasive methods to determine the severity of pulmonary extension is desired. This study aimed to describe the characteristics of sequential lung ultrasound and to test the prognostic usefulness of this exam in a group of patients admitted to the hospital with COVID-19. We prospectively evaluated patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection admitted to our hospital between April and August 2020.
      Lung Ultrasound Can Predict the Clinical Course and Severity of COVID-19 Disease
    • Original Contribution

      Modified Lung Ultrasound Score in Evaluating the Severity of Covid-19 Pneumonia

      Ultrasound in Medicine and Biology
      Vol. 47Issue 8p2080–2089Published online: April 30, 2021
      • Hilmi Erdem Sumbul
      • Ayse Selcan Koc
      • Arzu Pınar
      • Muhammed Zubeyir Aslan
      • Erdinc Gulumsek
      • Hasan Koca
      • and others
      Cited in Scopus: 3
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        Severe acute respiratory syndrome coronavirus 2 causes coronavirus disease 2019 (Covid-19), which has been declared as a pandemic by the World Health Organization. The aim of the study described here was to determine the severity of pneumonia and the clinical parameters related to a modified lung ultrasound score (mLUS) in patients with COVID-19 pneumonia. The study included 44 patients with proven COVID-19 pneumonia. Patients were divided into three groups on the basis of pneumonia severity: mild/moderate pneumonia (group I), severe pneumonia (group II) and critically ill patients (group III).
        Modified Lung Ultrasound Score in Evaluating the Severity of Covid-19 Pneumonia
      • Review

        Pulmonary Ultrasound in the Diagnosis and Monitoring of Coronavirus Disease (COVID-19): A Systematic Review

        Ultrasound in Medicine and Biology
        Vol. 47Issue 8p1997–2005Published online: April 20, 2021
        • Samuel Pecho-Silva
        • Ana Claudia Navarro-Solsol
        • Alvaro Taype-Rondan
        • Javier Torres-Valencia
        • Kovy Arteaga-Livias
        • Daniel Albert Herriman
        • and others
        Cited in Scopus: 5
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          The goal of this review was to systematize the evidence on pulmonary ultrasound (PU) use in diagnosis, monitorization or hospital discharge criteria for patients with coronavirus disease 2019 (COVID-19). Evidence on the use of PU for diagnosis and monitorization of or as hospital discharge criteria for COVID-19 patients confirmed to have COVID-19 by reverse transcription polymerase chain reaction (RT-PCR) between December 1, 2019 and July 5, 2020 was compared with evidence obtained with thoracic radiography (TR), chest computed tomography (CT) and RT-PCR.
          Pulmonary Ultrasound in the Diagnosis and Monitoring of Coronavirus Disease (COVID-19): A Systematic Review
        • Original Contribution
          Open Access

          Lung Assessment with Point-of-Care Ultrasound in Respiratory Coronavirus Disease (COVID-19): A Prospective Cohort Study

          Ultrasound in Medicine and Biology
          Vol. 47Issue 4p896–901Published online: December 25, 2020
          • Victor Speidel
          • Anna Conen
          • Valentin Gisler
          • Christoph A. Fux
          • Sebastian Haubitz
          Cited in Scopus: 8
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            Lung ultrasound (LUS) has shown promising diagnostic potential in different pulmonary conditions. We evaluated the diagnostic accuracy of LUS for pulmonary COVID-19. In this prospective cohort study at a Swiss tertiary care center, patients hospitalized with suspected COVID-19 were scanned using a 12-zone protocol. Association of a summation score (0–36 points) with the final diagnosis was tested using the area under the receiver operating characteristic curve and sensitivity and specificity at different cutoff points.
            Lung Assessment with Point-of-Care Ultrasound in Respiratory Coronavirus Disease (COVID-19): A Prospective Cohort Study
          • Original Contribution

            Chinese Expert Consensus on Protection for Ultrasound Healthcare Workers against COVID-19

            Ultrasound in Medicine and Biology
            Vol. 47Issue 2p222–229Published online: October 12, 2020
            • Yukun Luo
            • Jianjun Yuan
            • Minghui Liu
            • Nie Fang
            • Jiao Bai
            • Xiang Fei
            • and others
            Cited in Scopus: 0
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              Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has caused a worldwide pandemic and poses a serious public health risk. It has been proven that lung ultrasound can be extremely valuable in the diagnosis and treatment of the disease, which could also minimize the number of exposed healthcare workers and equipment. Because healthcare workers in ultrasound departments are in close contact with patients who might be infected or virus carriers, it is extremely important that they be provided sufficient protection.
              Chinese Expert Consensus on Protection for Ultrasound Healthcare Workers against COVID-19
            • Original Contribution

              Utility of Point-of-Care Lung Ultrasound for Clinical Classification of COVID-19

              Ultrasound in Medicine and Biology
              Vol. 47Issue 2p214–221Published online: September 21, 2020
              • Shu-Ting Zhu
              • Fang-Yi Tao
              • Jing-Hong Xu
              • Shu-Sheng Liao
              • Chuan-Li Shen
              • Zeng-Hui Liang
              • and others
              Cited in Scopus: 6
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                In this study, the utility of point-of-care lung ultrasound for clinical classification of coronavirus disease (COVID-19) was prospectively assessed. Twenty-seven adult patients with COVID-19 underwent bedside lung ultrasonography (LUS) examinations three times each within the first 2 wk of admission to the isolation ward. We divided the 81 exams into three groups (moderate, severe and critically ill). Lung scores were calculated as the sum of points. A rank sum test and bivariate correlation analysis were carried out to determine the correlation between LUS on admission and clinical classification of COVID-19.
                Utility of Point-of-Care Lung Ultrasound for Clinical Classification of COVID-19
              • Original Contribution

                Portable Pocket-Sized Ultrasound Scanner for the Evaluation of Lung Involvement in Coronavirus Disease 2019 Patients

                Ultrasound in Medicine and Biology
                Vol. 47Issue 1p19–24Published online: September 21, 2020
                • David Bennett
                • Elda De Vita
                • Fabrizio Mezzasalma
                • Nicola Lanzarone
                • Paolo Cameli
                • Francesco Bianchi
                • and others
                Cited in Scopus: 11
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                  Ultrasound imaging of the lung (LUS) and associated tissues has demonstrated clinical utility in coronavirus disease 2019 (COVID-19) patients. The aim of the present study was to evaluate the possibilities of a portable pocket-sized ultrasound scanner in the evaluation of lung involvement in patients with COVID-19 pneumonia. We conducted 437 paired readings in 34 LUS evaluations of hospitalized individuals with COVID-19. The LUS scans were performed on the same day with a standard high-end ultrasound scanner (Venue GO, GE Healthcare, Chicago, IL, USA) and a pocket-sized ultrasound scanner (Butterfly iQ, Butterfly Network Inc., Guilford, CT, USA).
                  Portable Pocket-Sized Ultrasound Scanner for the Evaluation of Lung Involvement in Coronavirus Disease 2019 Patients
                • Original Contribution

                  Lung Ultrasound Score in Evaluating the Severity of Coronavirus Disease 2019 (COVID-19) Pneumonia

                  Ultrasound in Medicine and Biology
                  Vol. 46Issue 11p2938–2944Published online: July 24, 2020
                  • Lina Zhao
                  • Kanglong Yu
                  • Qi Zhao
                  • Rui Tian
                  • Hui Xie
                  • Lijun Xie
                  • and others
                  Cited in Scopus: 25
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                    The purpose of this study is to observe the potential of lung ultrasound in evaluating the severity of coronavirus disease 2019 (COVID-19) pneumonia. Lung ultrasound was performed in ten zones of the patients' chest walls. The features of the ultrasound images were observed, and a lung ultrasound score (LUS) was recorded. The ultrasound features and scores were compared between the refractory group (PaO2/FiO2 ≤ 100 mm Hg or on extracorporeal membrane oxygenation) and the non-refractory group. The prediction value of the LUS was studied by receiver operating characteristic (ROC) curve analysis.
                    Lung Ultrasound Score in Evaluating the Severity of Coronavirus Disease 2019 (COVID-19) Pneumonia
                  • Review Article

                    Lung Ultrasound May Support Diagnosis and Monitoring of COVID-19 Pneumonia

                    Ultrasound in Medicine and Biology
                    Vol. 46Issue 11p2908–2917Published online: July 19, 2020
                    • Marco Allinovi
                    • Alberto Parise
                    • Martina Giacalone
                    • Andrea Amerio
                    • Marco Delsante
                    • Anna Odone
                    • and others
                    Cited in Scopus: 61
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                      Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) is characterized by severe pneumonia and/or acute respiratory distress syndrome in about 20% of infected patients. Computed tomography (CT) is the routine imaging technique for diagnosis and monitoring of COVID-19 pneumonia. Chest CT has high sensitivity for diagnosis of COVID-19, but is not universally available, requires an infected or unstable patient to be moved to the radiology unit with potential exposure of several people, necessitates proper sanification of the CT room after use and is underutilized in children and pregnant women because of concerns over radiation exposure.
                      Lung Ultrasound May Support Diagnosis and Monitoring of COVID-19 Pneumonia
                    • Original Contribution

                      Lung Ultrasound Findings Are Associated with Mortality and Need for Intensive Care Admission in COVID-19 Patients Evaluated in the Emergency Department

                      Ultrasound in Medicine and Biology
                      Vol. 46Issue 11p2927–2937Published online: July 15, 2020
                      • Nicola Bonadia
                      • Annamaria Carnicelli
                      • Alfonso Piano
                      • Danilo Buonsenso
                      • Emanuele Gilardi
                      • Cristina Kadhim
                      • and others
                      Cited in Scopus: 51
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                        Lung ultrasound (LUS) has recently been advocated as an accurate tool to diagnose coronavirus disease 2019 (COVID-19) pneumonia. However, reports on its use are based mainly on hypothesis studies, case reports or small retrospective case series, while the prognostic role of LUS in COVID-19 patients has not yet been established. We conducted a prospective study aimed at assessing the ability of LUS to predict mortality and intensive care unit admission of COVID-19 patients evaluated in a tertiary level emergency department.
                        Lung Ultrasound Findings Are Associated with Mortality and Need for Intensive Care Admission in COVID-19 Patients Evaluated in the Emergency Department
                      • Original Contribution

                        Correlation between Chest Computed Tomography and Lung Ultrasonography in Patients with Coronavirus Disease 2019 (COVID-19)

                        Ultrasound in Medicine and Biology
                        Vol. 46Issue 11p2918–2926Published online: July 13, 2020
                        • Yale Tung-Chen
                        • Milagros Martí de Gracia
                        • Aurea Díez-Tascón
                        • Rodrigo Alonso-González
                        • Sergio Agudo-Fernández
                        • Maria Luz Parra-Gordo
                        • and others
                        Cited in Scopus: 74
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                          There is growing evidence regarding chest X-ray and computed tomography (CT) findings for coronavirus disease 2019 (COVID-19). At present, the role of lung ultrasonography (LUS) has yet to be explored. The main purpose of this study was to evaluate the correlation between LUS findings and chest CT in patients confirmed to have (positive reverse transcription polymerase chain reaction [RT-PCR]) or clinically highly suspected of having (dyspnea, fever, myasthenia, gastrointestinal symptoms, dry cough, ageusia or anosmia) COVID-19.
                          Correlation between Chest Computed Tomography and Lung Ultrasonography in Patients with Coronavirus Disease 2019 (COVID-19)
                        • Original Contribution

                          Use of Lung Ultrasound to Differentiate Coronavirus Disease 2019 (COVID-19) Pneumonia From Community-Acquired Pneumonia

                          Ultrasound in Medicine and Biology
                          Vol. 46Issue 10p2651–2658Published online: June 5, 2020
                          • Guoliang Tan
                          • Xihua Lian
                          • Zhixing Zhu
                          • Zhenhua Wang
                          • Fang Huang
                          • Ying Zhang
                          • and others
                          Cited in Scopus: 30
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                            To investigate the feasibility of lung ultrasound in evaluating coronavirus disease 2019 (COVID-19) and distinguish the sonographic features between COVID-19 and community-acquired pneumonia (CAP), a total of 12 COVID-19 patients and 20 CAP patients were selected and underwent lung ultrasound. The modified Buda scoring system for interstitial lung disease was used to evaluate the severity and treatment effect of COVID-19 on ultrasonography. The differences between modified lung ultrasound (MLUS) score and high-resolution computed tomography (HRCT) Warrick score were analyzed to evaluate their correlation.
                            Use of Lung Ultrasound to Differentiate Coronavirus Disease 2019 (COVID-19) Pneumonia From Community-Acquired Pneumonia
                          • Letter to the Editor

                            Rationale for the Routine Application of Lung Ultrasound in the Management of Coronavirus Disease 2019 (COVID-19) Patients in Middle- to Low-Income Countries

                            Ultrasound in Medicine and Biology
                            Vol. 46Issue 9p2572–2574Published online: June 5, 2020
                            • Omar Yassef Antùnez-Montes
                            • Danilo Buonsenso
                            • Sergio Omar Paz-Ortega
                            Cited in Scopus: 2
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                              The global pandemic of coronavirus disease 2019 (COVID-19) (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) is an unprecedented event that is overloading health services worldwide. In México, the situation is no less worrying. When we started working with lung ultrasound (LUS) in México, 118 cases and 1 death had been registered in the country; at the time of writing of this article, 56,594 cases and 6090 deaths had been confirmed. The increase in cases and saturation of all medical services at all levels call for swift action and close attention, as well as precise diagnoses, especially in patients in respiratory distress.
                              Rationale for the Routine Application of Lung Ultrasound in the Management of Coronavirus Disease 2019 (COVID-19) Patients in Middle- to Low-Income Countries
                            • Clinical Note

                              A Review of Early Experience in Lung Ultrasound in the Diagnosis and Management of COVID-19

                              Ultrasound in Medicine and Biology
                              Vol. 46Issue 9p2530–2545Published online: May 25, 2020
                              • Laith R. Sultan
                              • Chandra M. Sehgal
                              Cited in Scopus: 51
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                                A novel coronavirus (2019-nCoV) was identified as the cause of a cluster of pneumonia in Wuhan, China, at the end of 2019. Since then more than eight million confirmed cases of coronavirus disease 2019 (COVID-19) have been reported around the globe. The current gold standard for etiologic diagnosis is reverse transcription–polymerase chain reaction analysis of respiratory-tract specimens, but the test has a high false-negative rate owing to both nasopharyngeal swab sampling error and viral burden.
                                A Review of Early Experience in Lung Ultrasound in the Diagnosis and Management of COVID-19
                              • Clinical Note

                                Lung Ultrasound in Patients with Acute Respiratory Failure Reduces Conventional Imaging and Health Care Provider Exposure to COVID-19

                                Ultrasound in Medicine and Biology
                                Vol. 46Issue 8p2090–2093Published online: May 5, 2020
                                • Silvia Mongodi
                                • Anita Orlando
                                • Eric Arisi
                                • Guido Tavazzi
                                • Erminio Santangelo
                                • Luca Caneva
                                • and others
                                Cited in Scopus: 44
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                                  Lung ultrasound gained a leading position in the last year as an imaging technique for the assessment and management of patients with acute respiratory failure. In coronavirus disease 2019 (COVID-19), its role may be of further importance because it is performed bedside and may limit chest X-ray and the need for transport to radiology for computed tomography (CT) scan. Since February 21, we progressively turned into a coronavirus-dedicated intensive care unit and applied an ultrasound-based approach to avoid traditional imaging and limit contamination as much as possible.
                                • Clinical Note

                                  Lung Ultrasound in Children with COVID-19: Preliminary Findings

                                  Ultrasound in Medicine and Biology
                                  Vol. 46Issue 8p2094–2098Published online: May 3, 2020
                                  • Anna Maria Musolino
                                  • Maria Chiara Supino
                                  • Danilo Buonsenso
                                  • Valentina Ferro
                                  • Piero Valentini
                                  • Andrea Magistrelli
                                  • and others
                                  Cited in Scopus: 89
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                                    Recent evidence indicates the usefulness of lung ultrasound (LUS) in detecting coronavirus disease 19 (COVID-19) pneumonia. However, no data are available on the use of LUS in children with COVID-19 pneumonia. In this report, we describe LUS features of 10 consecutively admitted children with COVID-19 in two tertiary-level pediatric hospitals in Rome. LUS revealed signs of lung involvement during COVID-19 infection. In particular, vertical artifacts (70%), pleural irregularities (60%), areas of white lung (10%) and subpleural consolidations (10%) were the main findings in patients with COVID-19.
                                    Lung Ultrasound in Children with COVID-19: Preliminary Findings
                                  • Letter to the Editor

                                    World Federation for Ultrasound in Medicine and Biology Position Statement: How to Perform a Safe Ultrasound Examination and Clean Equipment in the Context of COVID-19

                                    Ultrasound in Medicine and Biology
                                    Vol. 46Issue 7p1821–1826Published online: April 8, 2020
                                    • World Federation for Ultrasound in Medicine and Biology Safety Committee (Jacques S. Abramowicz, Iwaki Akiyama, David Evans, J. Brian Fowlkes, Karel Marsal, Yusef Sayeed and Gail ter Haar)
                                    • J.S. Abramowicz
                                    • J.M. Basseal
                                    Cited in Scopus: 55
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                                      On March 11, 2020, the World Health Organization formally declared the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (also known as COVID-19) a pandemic. This has impacted the way health care facilities operate globally to ensure patient and practitioner safety and to minimize all risks associated with infection transmission.
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