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    • Cover Image - Ultrasound in Medicine and Biology, Volume 49, Issue 5
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  • Review Article

    Guidelines and Good Clinical Practice Recommendations for Contrast-Enhanced Ultrasound (CEUS) in the Liver–Update 2020 WFUMB in Cooperation with EFSUMB, AFSUMB, AIUM, and FLAUS

    Ultrasound in Medicine and Biology
    Vol. 46Issue 10p2579–2604Published online: July 23, 2020
    • Christoph F. Dietrich
    • Christian Pállson Nolsøe
    • Richard G. Barr
    • Annalisa Berzigotti
    • Peter N. Burns
    • Vito Cantisani
    • and others
    Cited in Scopus: 146
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      The present, updated document describes the fourth iteration of recommendations for the hepatic use of contrast-enhanced ultrasound, first initiated in 2004 by the European Federation of Societies for Ultrasound in Medicine and Biology. The previous updated editions of the guidelines reflected changes in the available contrast agents and updated the guidelines not only for hepatic but also for non-hepatic applications. The 2012 guideline requires updating as, previously, the differences in the contrast agents were not precisely described and the differences in contrast phases as well as handling were not clearly indicated.
      Guidelines and Good Clinical Practice Recommendations for Contrast-Enhanced Ultrasound (CEUS) in the Liver–Update 2020 WFUMB in Cooperation with EFSUMB, AFSUMB, AIUM, and FLAUS
    • Review
      Open Access

      Liver Ultrasound Elastography: An Update to the World Federation for Ultrasound in Medicine and Biology Guidelines and Recommendations

      Ultrasound in Medicine and Biology
      Vol. 44Issue 12p2419–2440Published online: September 9, 2018
      • Giovanna Ferraioli
      • Vincent Wai-Sun Wong
      • Laurent Castera
      • Annalisa Berzigotti
      • Ioan Sporea
      • Christoph F Dietrich
      • and others
      Cited in Scopus: 253
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        The World Federation for Ultrasound in Medicine and Biology has produced these guidelines for the use of elastography techniques in liver diseases. For each available technique, the reproducibility, results and limitations are analyzed, and recommendations are given. This set of guidelines updates the first version, published in 2015. Since the prior guidelines, there have been several advances in technology. The recommendations are based on the international published literature, and the strength of each recommendation is judged according to the Oxford Centre for Evidence-Based Medicine.
        Liver Ultrasound Elastography: An Update to the World Federation for Ultrasound in Medicine and Biology Guidelines and Recommendations
      • WFUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography

        Foreword to the Second Set of WFUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography

        Ultrasound in Medicine and Biology
        Vol. 43Issue 1p1–3Published online: September 9, 2016
        • Richard G. Barr
        Cited in Scopus: 2
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          With the increased number of publications on elastography, the World Federation for Ultrasound in Medicine and Biology (WFUMB) leadership decided to take initiative to create guidelines in August 2011. The first consensus meeting was held in March 2013 and led to the development of guidelines for basic science (Shiina et al. 2015), breast (Barr et al. 2015) and liver (Ferraioli et al. 2015) elastography. With the increasing number of publications and interest in thyroid and prostate elastography, WFUMB convened a panel of worldwide experts to provide guidelines for these applications of elastography.
        • WFUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography

          WFUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography: Part 5. Prostate

          Ultrasound in Medicine and Biology
          Vol. 43Issue 1p27–48Published online: August 26, 2016
          • Richard G. Barr
          • David Cosgrove
          • Marko Brock
          • Vito Cantisani
          • Jean Michel Correas
          • Arnoud W. Postema
          • and others
          Cited in Scopus: 105
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            The World Federation for Ultrasound in Medicine and Biology (WFUMB) has produced guidelines for the use of elastography techniques, including basic science, breast, liver and thyroid elastography. Here we present elastography in prostate diseases. For each available technique, procedure, reproducibility, results and limitations are analyzed and recommendations are given. Finally, recommendations are given based on the level of evidence of the published literature and on the WFUMB expert group's consensus.
            WFUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography: Part 5. Prostate
          • WFUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography

            WFUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography: Part 4. Thyroid

            Ultrasound in Medicine and Biology
            Vol. 43Issue 1p4–26Published online: August 26, 2016
            • David Cosgrove
            • Richard Barr
            • Joerg Bojunga
            • Vito Cantisani
            • Maria Cristina Chammas
            • Manjiri Dighe
            • and others
            Cited in Scopus: 178
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              The World Federation for Ultrasound in Medicine and Biology (WFUMB) has produced guidelines for the use of elastography techniques including basic science, breast and liver. Here we present elastography in thyroid diseases. For each available technique, procedure, reproducibility, results and limitations are analyzed and recommendations are given. Finally, recommendations are given based on the level of evidence of the published literature and on the WFUMB expert group's consensus. The document has a clinical perspective and is aimed at assessing the usefulness of elastography in the management of thyroid diseases.
              WFUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography: Part 4. Thyroid
            • Wfumb Guidelines and Recommendations on the Clinical use of Ultrasound Elastography
              Open Access

              WFUMB Guidelines and Recommendations for Clinical Use of Ultrasound Elastography: Part 1: Basic Principles and Terminology

              Ultrasound in Medicine and Biology
              Vol. 41Issue 5p1126–1147Published online: March 24, 2015
              • Tsuyoshi Shiina
              • Kathryn R. Nightingale
              • Mark L. Palmeri
              • Timothy J. Hall
              • Jeffrey C. Bamber
              • Richard G. Barr
              • and others
              Cited in Scopus: 592
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                Conventional diagnostic ultrasound images of the anatomy (as opposed to blood flow) reveal differences in the acoustic properties of soft tissues (mainly echogenicity but also, to some extent, attenuation), whereas ultrasound-based elasticity images are able to reveal the differences in the elastic properties of soft tissues (e.g., elasticity and viscosity). The benefit of elasticity imaging lies in the fact that many soft tissues can share similar ultrasonic echogenicities but may have different mechanical properties that can be used to clearly visualize normal anatomy and delineate pathologic lesions.
                WFUMB Guidelines and Recommendations for Clinical Use of Ultrasound Elastography: Part 1: Basic Principles and Terminology
              • WFUMB Guidelines and Recommendations on the Clinical use of Ultrasound Elastography
                Open Access

                Foreword to the WFUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography

                Ultrasound in Medicine and Biology
                Vol. 41Issue 5p1125Published online: March 22, 2015
                • Masatoshi Kudo
                Cited in Scopus: 1
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                  The recent trend of a significant increase in publications on elastography evoked the World Federation for Ultrasound in Medicine and Biology (WFUMB) to feel the urgent need to create guidelines on the clinical use of elastography. At the WFUMB congress in Vienna in August 2011, the WFUMB leadership decided to take initiative to create the guidelines; the first consensus meeting was held in March 2013 in Washington, DC, and this was followed by sponsoring an elastography consensus session at the WFUMB Congress in San Paolo in May 2013.
                • Wfumb Guidelines and Recommendations on the Clinical use of Ultrasound Elastography
                  Open Access

                  WFUMB Guidelines and Recommendations for Clinical Use of Ultrasound Elastography: Part 3: Liver

                  Ultrasound in Medicine and Biology
                  Vol. 41Issue 5p1161–1179Published online: March 20, 2015
                  • Giovanna Ferraioli
                  • Carlo Filice
                  • Laurent Castera
                  • Byung Ihn Choi
                  • Ioan Sporea
                  • Stephanie R. Wilson
                  • and others
                  Cited in Scopus: 463
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                    The World Federation for Ultrasound in Medicine and Biology (WFUMB) has produced these guidelines for the use of elastography techniques in liver disease. For each available technique, the reproducibility, results, and limitations are analyzed, and recommendations are given. Finally, recommendations based on the international literature and the findings of the WFUMB expert group are established as answers to common questions. The document has a clinical perspective and is aimed at assessing the usefulness of elastography in the management of liver diseases.
                    WFUMB Guidelines and Recommendations for Clinical Use of Ultrasound Elastography: Part 3: Liver
                  • Wfumb Guidelines and Recommendations on the Clinical use of Ultrasound Elastography
                    Open Access

                    WFUMB Guidelines and Recommendations for Clinical Use of Ultrasound Elastography: Part 2: Breast

                    Ultrasound in Medicine and Biology
                    Vol. 41Issue 5p1148–1160Published online: March 19, 2015
                    • Richard G. Barr
                    • Kazutaka Nakashima
                    • Dominique Amy
                    • David Cosgrove
                    • Andre Farrokh
                    • Fritz Schafer
                    • and others
                    Cited in Scopus: 328
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                      The breast section of these Guidelines and Recommendations for Elastography produced under the auspices of the World Federation of Ultrasound in Medicine and Biology (WFUMB) assesses the clinically used applications of all forms of elastography used in breast imaging. The literature on various breast elastography techniques is reviewed, and recommendations are made on evidence-based results. Practical advice is given on how to perform and interpret breast elastography for optimal results, with emphasis placed on avoiding pitfalls.
                      WFUMB Guidelines and Recommendations for Clinical Use of Ultrasound Elastography: Part 2: Breast
                    • Historical review

                      Biological effects of ultrasound: Development of safety guidelines. Part II: General review

                      Ultrasound in Medicine and Biology
                      Vol. 27Issue 3p301–333Published in issue: March, 2001
                      • Wesley L. Nyborg
                      Cited in Scopus: 231
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                        In the 1920s, the availability of piezoelectric materials and electronic devices made it possible to produce ultrasound (US) in water at high amplitudes, so that it could be detected after propagation through large distances. Laboratory experiments with this new mechanical form of radiation showed that it was capable of producing an astonishing variety of physical, chemical and biologic effects. In this review, the early findings on bioeffects are discussed, especially those from experiments done in the first few decades, as well as the concepts employed in explaining them.
                        Biological effects of ultrasound: Development of safety guidelines. Part II: General review
                      • Historical review

                        Biological effects of ultrasound: development of safety guidelines: Part I: personal histories

                        Ultrasound in Medicine and Biology
                        Vol. 26Issue 6p911–964Published in issue: July, 2000
                        • Wesley L Nyborg
                        Cited in Scopus: 29
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                          After the end of World War II, advances in ultrasound (US) technology brought improved possibilities for medical applications. The first major efforts in this direction were in the use of US to treat diseases. Medical studies were accompanied by experiments with laboratory animals and other model systems to investigate basic biological questions and to obtain better understanding of mechanisms. Also, improvements were made in methods for measuring and controlling acoustical quantities such as power, intensity and pressure.
                          Biological effects of ultrasound: development of safety guidelines
                        • Review

                          International recommendations and guidelines for the safe use of diagnostic ultrasound in medicine

                          Ultrasound in Medicine and Biology
                          Vol. 26Issue 3p355–366Published in issue: March, 2000
                          • Stanley B Barnett
                          • Gail R Ter Haar
                          • Marvin C Ziskin
                          • Hans-Dieter Rott
                          • Francis A Duck
                          • Kazuo Maeda
                          Cited in Scopus: 270
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                            Modern sophisticated ultrasonographic equipment is capable of delivering substantial levels of acoustic energy into the body when used at maximum outputs. The risk of producing bioeffects has been studied by international expert groups during symposia supported by the World Federation for Ultrasound in Medicine and Biology (WFUMB). These have resulted in the publication of internationally accepted conclusions and recommendations. National ultrasound safety committees have published guidelines as well.
                          • Abstract

                            Part IV: Physics and Instrumentation

                            Ultrasound in Medicine and Biology
                            Vol. 26SupplementA51–A74Published in issue: 2000
                            Cited in Scopus: 0
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                            • Abstract

                              Part VII: Internal medicine

                              Ultrasound in Medicine and Biology
                              Vol. 26SupplementA117–A172Published in issue: 2000
                              Cited in Scopus: 0
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                              • Abstract

                                Part IX: Obstetrics and Gynecology

                                Ultrasound in Medicine and Biology
                                Vol. 26SupplementA201–A218Published in issue: 2000
                                Cited in Scopus: 0
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                                • Abstract

                                  Part XI: Ophthalmology

                                  Ultrasound in Medicine and Biology
                                  Vol. 26SupplementA233–A238Published in issue: 2000
                                  Cited in Scopus: 0
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                                  • Abstract

                                    Part XII: Miscellaneous

                                    Ultrasound in Medicine and Biology
                                    Vol. 26SupplementA240–A243Published in issue: 2000
                                    Cited in Scopus: 0
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