Objective
Histotripsy is an emerging non-invasive, non-ionizing and non-thermal focal tumor
therapy. Although histotripsy targeting is currently based on ultrasound (US), other
imaging modalities such as cone-beam computed tomography (CBCT) have recently been
proposed to enable the treatment of tumors not visible on ultrasound. The objective
of this study was to develop and evaluate a multi-modality phantom to facilitate the
assessment of histotripsy treatment zones on both US and CBCT imaging.
Methods
Fifteen red blood cell phantoms composed of alternating layers with and without barium
were manufactured. Spherical 25-mm histotripsy treatments were performed, and treatment
zone size and location were measured on CBCT and ultrasound. Sound speed, impedance
and attenuation were measured for each layer type.
Results
The average ± standard deviation signed difference between measured treatment diameters
was 0.29 ± 1.25 mm. The Euclidean distance between measured treatment centers was
1.68 ± 0.63 mm. The sound speed in the different layers ranged from 1491 to 1514 m/s
and was within typically reported soft tissue ranges (1480–1560 m/s). In all phantoms,
histotripsy resulted in sharply delineated treatment zones, allowing segmentation
in both modalities.
Conclusion
These phantoms will aid in the development and validation of X-ray-based histotripsy
targeting techniques, which promise to expand the scope of treatable lesions beyond
only those visible on ultrasound.
Keywords
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Article info
Publication history
Published online: March 04, 2023
Accepted:
January 23,
2023
Received in revised form:
December 9,
2022
Received:
October 8,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
