Objective
Cancer treatment using ultrasound irradiation with low intensities along with a sonosensitizer
has been found to have significant advantages, such as high penetration depth in tissues,
non-invasive therapeutic character, minor side effects, good patient adherence and
preferential tumor area treatment. In the present study, gold nanoparticles covered
by poly(ortho-aminophenol) ([email protected] NPs) were synthesized and characterized as a new
sonosensitizer.
Methods
We investigated [email protected] NPs efficacy on fractionated ultrasound irradiation for treatment
of melanoma cancer in vitro as well as in vivo.
Discussion
In vitro examinations revealed that although [email protected] NPs (with a mean size of 9.8 nm) alone
represented concentration-dependent cytotoxicity against the B16/F10 cell line, multistep
ultrasound irradiation (1 MHz frequency, 1.0 W/cm2 intensity, 60 s irradiation time) of the cells in the attendance of [email protected] NPs led
to efficient cell sonodynamic therapy (SDT) and death. Histological analyses revealed
that in vivo fractionated SDT toward melanoma tumors of male balb/c mice led to no residual viable
tumor cell after 10 d.
Conclusion
A deep sonosensitizing effectiveness of [email protected] NPs on fractionated low-intensity
ultrasound irradiation was attained with the main mechanism of tumor cell eradication
of promotion of apoptosis or necrosis through dramatically increased reactive oxygen
species levels.
Keywords
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Article info
Publication history
Published online: February 25, 2023
Accepted:
January 23,
2023
Received in revised form:
January 17,
2023
Received:
August 14,
2022
Identification
Copyright
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