Objective
Glucose homeostasis is the only way to manage diabetic progression as all medications
used do not cure diabetes. This study was aimed at verifying the feasibility of lowering
glucose with non-invasive ultrasonic stimulation.
Methods
The ultrasonic device was homemade and controlled via a mobile application on the
smartphone. Diabetes was induced in Sprague–Dawley rats through high-fat diets followed
by streptozotocin injection. The treated acupoint CV12 was at the middle of the xiphoid
and umbilicus of the diabetic rats. Parameters of ultrasonic stimulation were an operating
frequency of 1 MHz, pulse repetition frequency of 15 Hz, duty cycle of 10% and sonication
time of 30 min for a single treatment.
Discussion
The diabetic rats exhibited a significant decrease of 11.5% ± 3.6% in blood glucose
in 5 min of ultrasonic stimulation (p < 0.001). After the single treatment on the first day, third day and fifth day in
the first week, the treated diabetic rats had a significantly small area under the
curve of the glucose tolerance test (p < 0.05) compared with the untreated diabetic rats in the sixth week. Hematological
analyses indicated that the serum concentrations of β-endorphin were significantly
increased by 58% ± 71.9% (p < 0.05) and the insulin level was increased by 56% ± 88.2% (p = 0.15) without statistical significance after a single treatment.
Conclusion
Therefore, non-invasive ultrasound stimulation at an appropriate dose can produce
a hypoglycemic effect and improve glucose tolerance for glucose homeostasis and may
play a role as adjuvant therapy with diabetic medications in the future.
Keywords
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Article info
Publication history
Published online: February 19, 2023
Accepted:
January 17,
2023
Received in revised form:
January 5,
2023
Received:
August 16,
2022
Identification
Copyright
© 2023 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
