Objective
Phase aberration from soft tissue limits the efficacy of histotripsy, a therapeutic
ultrasound technique based on acoustic cavitation. Previous work has shown that the
acoustic emissions from cavitation can serve as “point sources” for aberration correction
(AC). This study compared the efficacy of soft tissue AC for histotripsy using acoustic
cavitation emissions (ACE) from bubble cloud nucleation and collapse.
Methods
A 750-kHz, receive-capable histotripsy array was pulsed to generate cavitation in
ex vivo porcine liver through an intervening abdominal wall. Received ACE signals were used
to determine the arrival time differences to the focus and compute corrective delays.
Corrections from single pulses and from the median of multiple pulses were tested.
Discussion
On average, ACE AC obtained 96% ± 3% of the pressure amplitude obtained by hydrophone-based
correction (compared with 71% ± 5% without AC). Both nucleation- and collapse-based
corrections obtained >96% of the hydrophone-corrected pressure when using medians
of ≥10 pulses. When using single-pulse corrections, nucleation obtained a range of
49%–99% of the hydrophone-corrected pressure, while collapse obtained 95%–99%.
Conclusion
The results suggest that (i) ACE AC can recover nearly all pressure amplitude lost
owing to soft tissue aberration and that (ii) the collapse signal permits robust AC
using a small number of pulses.
Keywords
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References
- For whom the bubble grows: physical principles of bubble nucleation and dynamics in histotripsy ultrasound therapy.Ultrasound Med Biol. 2019; 45: 1056-1080
- Histotripsy methods in mechanical disintegration of tissue: towards clinical applications.Int J Hyperthermia. 2015; 31: 145-162
- Effects of acoustic parameters on bubble cloud dynamics in ultrasound tissue erosion (histotripsy).J Acoust Soc Am. 2007; 122: 229-236
- Controlled ultrasound tissue erosion.IEEE Trans Ultrason Ferroelectr Freq Control. 2004; 51: 726-736
- Cavitation clouds created by shock scattering from bubbles during histotripsy.J Acoust Soc Am. 2011; 130: 1888-1898
- Noninvasive thrombolysis using pulsed ultrasound cavitation therapy—histotripsy.Ultrasound Med Biol. 2009; 35: 1982-1994
- Effects of ultrasound frequency and tissue stiffness on the histotripsy intrinsic threshold for cavitation.Ultrasound Med Biol. 2015; 41: 1651-1667
- Evolution of bubble clouds induced by pulsed cavitational ultrasound therapy—histotripsy.IEEE Trans Ultrason Ferroelectr Freq Control. 2008; 55: 1122-1132
- Investigation of the long-term healing response of the liver to boiling histotripsy treatment in vivo.Sci Rep. 2022; 12: 14462
- Pilot in vivo studies on transcutaneous boiling histotripsy in porcine liver and kidney.Sci Rep. 2019; 9: 20176
- Controlled tissue emulsification produced by high intensity focused ultrasound shock waves and millisecond boiling.J Acoust Soc Am. 2011; 130: 3498-3510
- The interaction of shockwaves with a vapour bubble in boiling histotripsy: the shock scattering effect.Ultrason Sonochem. 2021; 70105312
- Mechanical damage induced by the appearance of rectified bubble growth in a viscoelastic medium during boiling histotripsy exposure.Ultrason Sonochem. 2019; 53: 164-177
- Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound.Int J Hyperthermia. 2021; 38: 561-575
- Transcostal histotripsy ablation in an in vivo acute hepatic porcine model.Cardiovasc Intervent Radiol. 2021; 44: 1643-1650
- Histotripsy: minimally invasive technology for prostatic tissue ablation in an in vivo canine model.Urology. 2008; 72: 682-686
- Histotripsy ablations in a porcine liver model: feasibility of respiratory motion compensation by alteration of the ablation zone prescription shape.Cardiovasc Intervent Radiol. 2020; 43: 1695-1701
- Development and translation of histotripsy: current status and future directions.Curr Opin Urol. 2014; 24: 104-110
- Pulsed cavitational ultrasound: a noninvasive technology for controlled tissue ablation (histotripsy) in the rabbit kidney.J Urol. 2006; 175: 734-738
- Histotripsy of VX-2 tumor implanted in a renal rabbit model.J Endourol. 2010; 24: 1145-1150
- First-in-man histotripsy of hepatic tumors: the THERESA trial, a feasibility study.Int J Hyperthermia. 2022; 39: 1115-1123
- Non-invasive liver ablation using histotripsy: preclinical safety study in an in vivo porcine model.Ultrasound Med Biol. 2017; 43: 1237-1251
- Image-guided non-invasive ultrasound liver ablation using histotripsy: feasibility study in an in vivo porcine model.Ultrasound Med Biol. 2013; 39: 1398-1409
- Probability of cavitation for single ultrasound pulses applied to tissues and tissue-mimicking materials.Ultrasound Med Biol. 2013; 39: 449-465
- Phase aberration measurements in medical ultrasound: human studies.Ultrason Imaging. 1988; 10: 1-11
- The effect of abdominal wall morphology on ultrasonic pulse distortion: Part I. Measurements.J Acoust Soc Am. 1998; 104: 3635-3649
- On the relationship between spatial coherence and in situ pressure for abdominal imaging.Ultrasound Med Biol. 2021; 47: 2310-2320
- Phase-aberration correction using signals from point reflectors and diffuse scatterers: basic principles.IEEE Trans Ultrason Ferroelectr Freq Control. 1988; 35: 758-767
- Measurements of ultrasonic pulse arrival time differences produced by abdominal wall specimens.J Acoust Soc Am. 1991; 90: 2924-2930
- Correction of ultrasonic wavefront distortion using backpropagation and a reference waveform method for time-shift compensation.J Acoust Soc Am. 1994; 96: 649-660
- Attenuation and de-focusing during high-intensity focused ultrasound therapy through peri-nephric fat.Ultrasound Med Biol. 2013; 39: 1785-1793
- Effects of breast structure on high-intensity focused ultrasound focal error.J Ther Ultrasound. 2018; 6: 4
- Bilayer aberration-inducing gel phantom for high intensity focused ultrasound applications.J Acoust Soc Am. 2020; 148: 3569-3580
- Effect of abdominal wall inhomogeneities on the focusing of an ultrasonic beam at different positions of the transducer.Bull Russ Acad Sci Phys. 2021; 85: 675-680
- Histotripsy beyond the intrinsic cavitation threshold using very short ultrasound pulses: microtripsy.IEEE Trans Ultrason Ferroelectr Freq Control. 2014; 61: 251-265
- Focus shift and phase correction in soft tissues during focused ultrasound surgery.IEEE Trans Biomed Eng. 2011; 58: 1621-1628
- Effects of phase aberration on transabdominal focusing for a large aperture, low f-number histotripsy transducer.Phys Med Biol. 2022; 67155004
- Experimental assessment of phase aberration correction for breast MRgFUS therapy.Int J Hyperthermia. 2018; 34: 731-743
- A comparison of methods for focusing the field of a HIFU array transducer through human ribs.Phys Med Biol. 2014; 59: 3139-3171
- High intensity focused ultrasound with large aperture transducers: a MRI based focal point correction for tissue heterogeneity.Med Phys. 2012; 39: 1936-1945
- Delivering focused ultrasound to intervertebral discs using time-reversal.Ultrasound Med Biol. 2019; 45: 2405-2416
- A method for MRI guidance of intercostal high intensity focused ultrasound ablation in the liver.Med Phys. 2010; 37: 2533-2540
- Sensitivity of simulated transcranial ultrasound fields to acoustic medium property maps.Phys Med Biol. 2017; 62: 2559-2580
- Dosimetry implications for correct ultrasound dose deposition: uncertainties in descriptors, planning and treatment delivery.Transl Cancer Res. 2014; 3: 459-471
- Phase-aberration correction for HIFU therapy using a multielement array and backscattering of nonlinear pulses.IEEE Trans Ultrason Ferroelectr Freq Control. 2021; 68: 1040-1050
- In vivo aberration correction for transcutaneous HIFU therapy using a multi-element array.IEEE Trans Ultrason Ferroelectr Freq Control. 2022; 69: 2955-2964
- Time reversal of ultrasonic fields: I. Basic principles.IEEE Trans Ultrason Ferroelectr Freq Control. 1992; 39: 555-566
- Time reversal of ultrasonic fields: II. Experimental results.IEEE Trans Ultrason Ferroelectr Freq Control. 1992; 39: 567-578
- In vivo droplet vaporization for occlusion therapy and phase aberration correction.IEEE Trans Ultrason Ferroelectr Freq Control. 2002; 49: 726-738
- Potential of microbubbles for use as point targets in phase aberration correction.IEEE Trans Ultrason Ferroelectr Freq Control. 2004; 51: 1639-1648
- Ultrasonic stars” for time-reversal focusing using induced cavitation bubbles.Appl Phys Lett. 2006; 88034102
- Towards aberration correction of transcranial ultrasound using acoustic droplet vaporization.Ultrasound Med Biol. 2008; 34: 435-445
- Transcranial ultrasonic therapy based on time reversal of acoustically induced cavitation bubble signature.IEEE Trans Biomed Eng. 2010; 57: 134-144
- Real-time transcranial histotripsy treatment localization and mapping using acoustic cavitation emission feedback.IEEE Trans Ultrason Ferroelectr Freq Control. 2020; 67: 1178-1191
- The acoustic bubble.Academic Press, San Diego, CA1994
- Inertial cavitation and associated acoustic emission produced during electrohydraulic shock wave lithotripsy.J Acoust Soc Am. 1997; 101: 2940-2950
- Periodic shock-emission from acoustically driven cavitation clouds: A source of the subharmonic signal.Ultrasonics. 2014; 54: 2151-2158
- Shock wave emission by laser generated bubbles.(editor)in: Delale CF Bubble dynamics and shock waves. Springer, Berlin/Heidelberg2013: 67-103
- Soft-tissue aberration correction for histotripsy.IEEE Trans Ultrason Ferroelectr Freq Control. 2018; 65: 2073-2085
- Shockwaves from Cavity Collapse.Philos Trans R Soc Lond Ser Math Phys Sci. 1966; 260: 241-244
- Observations of shock waves in cloud cavitation.J Fluid Mech. 1998; 355: 255-283
- Jet formation and shock wave emission during collapse of ultrasound-induced cavitation bubbles and their role in the therapeutic applications of high-intensity focused ultrasound.Phys Med Biol. 2005; 50: 4797-4809
- Using the cavitation collapse time to indicate the extent of histotripsy-induced tissue fractionation.Phys Med Biol. 2018; 63055013
- Two-step aberration correction: application to transcranial histotripsy.Phys Med Biol. 2022; 67125009
- On the collapse of cavity clusters in flow cavitation.(editor)in: Lauterborn W Cavitation and inhomogeneities in underwater acoustics. Springer, Berlin/Heidelberg1980: 95-100
- Shock wave development in the collapse of a cloud of bubbles.Cavitation and multiphase flow. (Fluids Engineering Division, Vol. 194. American Society of Mechanical Engineers, New York1994: 15-19
- Simulation and analysis of collapsing vapor-bubble clusters with special emphasis on potentially erosive impact loads at walls.EPJ Web Conf. 2018; 180: 02079
- Effects of f-number on the histotripsy intrinsic threshold and cavitation bubble cloud behavior.Phys Med Biol. 2017; 62: 1269-1290
- A modular, kerf-minimizing approach for therapeutic ultrasound phased array construction.IEEE Trans Ultrason Ferroelectr Freq Control. 2022; 69: 2766-2775
- Acoustic time-reversal mirrors.Inverse Probl. 2001; 17: R1-38
- Rapid full-wave phase aberration correction method for transcranial high-intensity focused ultrasound therapies.J Ther Ultrasound. 2016; 4: 30
- Experimental demonstration of noninvasive transskull adaptive focusing based on prior computed tomography scans.J Acoust Soc Am. 2003; 113: 84-93
- A non-invasive method for focusing ultrasound through the human skull.Phys Med Biol. 2002; 47: 1219-1236
- Non-invasive transcranial ultrasound therapy based on a 3D CT scan: protocol validation and in vitro results.Phys Med Biol. 2009; 54: 2597-2613
- Dependence of inertial cavitation induced by high intensity focused ultrasound on transducer F-number and nonlinear waveform distortion.J Acoust Soc Am. 2018; 144: 1160-1169
- Amplitude and phase relation of harmonics in nonlinear focused ultrasound.AIP Adv. 2022; 12065317
- Visualization of the intensity field of a focused ultrasound source in situ.IEEE Trans Med Imaging. 2019; 38: 124-133
- Combined therapy planning, real-time monitoring, and low intensity focused ultrasound treatment using a diagnostic imaging array.IEEE Trans Med Imaging. 2022; 41: 1410-1419
- Real-time visualization of a focused ultrasound beam using ultrasonic backscatter.IEEE Trans Ultrason Ferroelectr Freq Control. 2021; 68: 1213-1223
- Acoustic beam mapping for guiding HIFU therapy in vivo using sub-therapeutic sound pulse and passive beamforming.IEEE Trans Biomed Eng. 2022; 69: 1663-1673
- An X-ray C-arm Guided Automatic Targeting System for Histotripsy.IEEE Trans Biomed Eng. 2022; : 1-12
Article info
Publication history
Published online: February 07, 2023
Accepted:
January 3,
2023
Received in revised form:
December 1,
2022
Received:
August 26,
2022
Identification
Copyright
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