The purpose of this meta-analysis was to evaluate the diagnostic performance of shear
wave elastography (SWE) for the staging of renal fibrosis in patients with chronic
kidney disease (CKD). Classification of CKD into mild, moderate and severe fibrosis
was based on renal biopsy pathology (glomerulosclerosis, tubulointerstitial injury
and vascular sclerosis). The Cochrane Library, Medline, PubMed, Web of Science, EMBASE
and CNKI databases were searched from January 1, 2009, to April 20, 2022. Pooled sensitivity,
specificity, diagnostic odds ratio and area under the receiver operating characteristic
curve (AUROC) were calculated using random effects models. A total of 1394 patients
from 14 studies were included in the final analysis. For mild, moderate and severe
renal fibrosis, SWE had a sensitivity of 0.79 (95% confidence interval [CI]: 0.67–0.88),
0.73 (95% CI: 0.65–0.80) and 0.87 (95% CI: 0.71–0.95); a specificity of 0.82 (95%
CI: 0.75–0.87), 72% (95% CI: 0.67–0.77) and 0.83 (95% CI: 0.80–0.86); an AUROC of
0.87 (95% CI: 0.84–0.90), 0.78 (95% CI: 0.75–0.82) and 0.86 (95% CI: 0.82–0.88); and
a diagnostic odds ratio of 17 (95% CI: 7–43), 7 (95% CI: 4–12) and 34 (95% CI: 13–88),
respectively. Meta-regressions revealed that the publication date, system used and
number of valid measurements of SWE were the main causes of heterogeneity. SWE is
a good technique for diagnosing mild and severe renal fibrosis, as well as a fair
technique for diagnosing moderate fibrosis.
Keywords
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Article info
Publication history
Published online: February 04, 2023
Accepted:
January 2,
2023
Received in revised form:
December 5,
2022
Received:
August 31,
2022
Identification
Copyright
© 2023 Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biology.
