Objective
The need for ultrasound flow phantoms to validate ultrasound systems requires the
development of materials that can clearly visualize the flow inside for measurement
purposes.
Methods
A transparent ultrasound flow phantom material composed of poly(vinyl alcohol) hydrogel
(PVA-H) with dimethyl sulfoxide (DMSO) and water solution manufactured using the freezing
method and mixed with quartz glass powder to exhibit scattering effects is proposed.
To achieve transparency of the hydrogel phantom, the refractive index (RI) was changed
to match that of the glass by modifying the PVA concentration and the ratio of DMSO
to water in the solvent. The feasibility of optical particle image velocimetry (PIV)
was verified by comparing an acrylic rectangular cross-section channel with a rigid
wall. After the feasibility tests, an ultrasound flow phantom was fabricated to conduct
ultrasound B-mode visualization and Doppler–PIV comparison.
Discussion
The results revealed that the PIV measured through PVA-H material exhibited 0.8% error
in the measured maximum velocity compared with PIV through the acrylic material. B-mode
images are similar to real tissue visualization with a limitation of a higher sound
velocity, when compared with human tissue, of 1792 m/s. Doppler measurement of the
phantom revealed approximately 120% and 19% overestimation of maximum and mean velocities,
respectively, compared with those from PIV.
Conclusion
The proposed material possesses the advantage of the single-phantom ability to improve
the ultrasound flow phantom for validation of flow.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Ultrasound in Medicine and BiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Diagnostic ultrasound: imaging and blood flow measurements.CRC Press, Boca Raton, FL2005
- Detection of vertebrobasilar intracranial stenoses: transcranial Doppler sonography versus angiography.J Ultrasound Med. 1997; 16: 213-218
- Transcranial Doppler sonography is not a valid diagnostic tool for detection of basilar artery stenosis or in-stent restenosis: a retrospective diagnostic study.BMC Neurol. 2017; 17: 1-6
- A review of the measurement of blood velocity and related quantities using Doppler ultrasound.J Eng Med. 1999; 213: 391-400
- Fabrication of two flow phantoms for doppler ultrasound imaging.IEEE Trans Ultrason Ferroelectr Freq Control. 2017; 64: 53-65
- Assessment of the acoustic properties of common tissue-mimicking test phantoms.Ultrasound Med Biol. 2003; 29: 1053-1060
- A velocity evaluation phantom for colour and pulsed doppler instruments.Ultrasound Med Biol. 1992; 18: 479-494
- Sources of error in maximum velocity estimation using linear phased-array Doppler systems with steady flow.Ultrasound Med Biol. 2001; 27: 655-664
- A dual-phantom system for validation of velocity measurements in stenosis models under steady flow.Ultrasound Med Biol. 2009; 35: 1510-1524
- Simulation and validation of arterial ultrasound imaging and blood flow.Ultrasound Med Biol. 2008; 34: 693-717
- Reusable tissue-mimicking hydrogel phantoms for focused ultrasound ablation.Ultrason Sonochem. 2015; 23: 399-405
- Poly(vinyl alcohol) gel ultrasound phantom with durability and visibility of internal flow.J Med Ultrason. 2015; 42: 17-23
- Poly-vinyl alcohol hydrogel vascular models for in vitro aneurysm simulations: the key to low friction surfaces.Technol Heal Care. 2004; 12: 225-233
- Mechanical properties of tube-shaped poly (vinyl alcohol) hydrogel blood vessel biomodel.in: Proceedings of the ASME 2010 3rd Joint US–European Fluids Engineering Summer meeting. ASME, Montreal, QC, Canada. New York2010: 1877-1883
- Effects of wall compliance on multiharmonic pulsatile flow in idealized cerebral aneurysm models: comparative PIV experiments.Exp Fluids. 2020; 61: 1-11
- Ultrasound speckle and equivalent scatterers.Ultrasonics. 2005; 43: 405-420
- Preparation of transparent poly(vinyl alcohol) hydrogel.Polym Bull. 1989; 22: 119-122
- Measurements of dynamic viscoelasticity of poly(vinyl alcohol) hydrogel for the development of blood vessel biomodeling.J Fluid Sci Technol. 2008; 3: 533-543
- Scatterer number density considerations in reference phantom-based attenuation estimation.Ultrasound Med Biol. 2014; 40: 1680-1696
- Development of a methodology for adaptation of refractive index under controlling kinematic viscosity for PIV.in: ASME International Mechanical Engineering Congress and Exposition. 2. ASME, New York2011: 313-321
- Particle image velocimetry for MATLAB: accuracy and enhanced algorithms in PIVlab.J Open Res Softw. 2021; 9: 12
- Memoir on the influence of friction in the regular motion of fluids.J Math. 1868; 2
- (editors)Hoskins P Martin K Thrush A Diagnostic ultrasound: physics and equipment. 3rd ed. CRC Press, Boca Raton, FL2019
- Development and validation of echo PIV.Exp Fluids. 2004; 36: 455-462
- Continuum microhaemodynamics modelling using inverse rheology.Biomech Model Mechanobiol. 2022; 21: 335-361
- Sound velocity choice for modeling and measurement.Ultrasound Med Biol. 1989; 15: 23-25
- Density, viscosity, refractive index, and hygroscopicity of mixtures of water and dimethyl sulfoxide.J Chem Eng Data. 1962; 7: 100-101
- Characterization of acoustic, cavitation, and thermal properties of poly(vinyl alcohol) hydrogels for use as therapeutic ultrasound tissue mimics.Ultrasound Med Biol. 2022; 48: 1095-1109
- Tissue mimicking materials for ultrasound phantoms.Med Phys. 1978; 5: 391-394
- Anatomical flow phantoms of the nonplanar carotid bifurcation: Part II. Experimental validation with Doppler ultrasound.Ultrasound Med Biol. 2007; 33: 303-310
- Anatomical flow phantoms of the nonplanar carotid bifurcation: Part I. Computer-aided design and fabrication.Ultrasound Med Biol. 2007; 33: 296-302
Article info
Publication history
Published online: March 04, 2023
Accepted:
December 31,
2022
Received in revised form:
December 19,
2022
Received:
May 26,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 World Federation for Ultrasound in Medicine & Biology. All rights reserved.