Abstract—
Prolonged mechanical ventilation (PMV) is common among critically ill septic patients
and leads to serious adverse effects. Transthoracic echocardiography (TTE) is an efficient
tool for the assessment of septic shock. Our study investigated the relationship between
TTE parameters and PMV in mechanically ventilated septic shock patients. TTE was performed
in the first 24 h of intensive care unit admission, acquiring data on cardiac output
(CO), cardiac index (CI), s' wave (s'), E wave (E), e' wave (e') and E/e' ratio. We compared data on patients who met the criteria for PMV with data on patients
who did not. Sixty-four patients were included, 26 of whom met the criteria for PMV.
CO, CI and s' were higher in patients who required PMV (5.49 vs. 4.20, p = 0.02; 2.95 vs. 2.34, p = 0.04; and 12.56 vs. 9.81, p = 0.01, respectively). CI correlated with s' (r = 0.37, p < 0.01). The areas under the receiver operating characteristic curves for CO, CI
and s' in assessing the need for PMV were, respectively, 0.7 (fair results), 0.69 and 0.68
(poor results). Despite a lack of a prognostic model, the observed differences suggest
that hemodynamic TTE could provide information on the risk of PMV in septic shock.
Key Words
Abbreviations:
ICU (Intensive Care Unit), OI (Orotracheal Intubation), MV (Mechanical Ventilation), ARDS (Acute Respiratory Distress Syndrome), CO (Cardiac Output), SVR (Systemic Vascular Resistance), LV (Left Ventricle), TTE (Transthoracic Echocardiography), CI (Cardiac Index), TDI (Tissue Doppler Imaging), PMV (Prolonged Mechanical Ventilation), CCI (Chronic Critical Illness), ER (Emergency Room), NYHA (New York Heart Association), SBT (Spontaneous Breathing Trial), SV (Stroke Volume), HR (Heart Rate), LVOT CSA (Left Ventricular Outflow Tract Cross-Sectional Area), LVOT VTI (Left Ventricular Outflow Tract Velocity-Time Integral), RR (Respiratory Rate), BSA (Body Surface Area), MLE (Maximum likelihood estimation), LVEF (Left Ventricular Ejection Fraction)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: November 28, 2022
Accepted:
November 3,
2022
Received in revised form:
October 4,
2022
Received:
May 11,
2022
Identification
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