Abstract
Ultrasound-guided needle interventions are common procedures in medicine, and tissue-mimicking
phantoms are widely used for simulation training to bridge the gap between theory
and clinical practice in a controlled environment. This review assesses tissue-mimicking
materials from 24 studies as candidates for a high-fidelity ultrasound phantom, including
methods for evaluating relevant acoustic and mechanical properties and to what extent
the reported materials mimic the superficial layers of biological tissue. Speed of
sound, acoustic attenuation, Young's modulus, hardness, needle interaction forces,
training efficiency and material limitations were systematically evaluated. Although
gelatin and agar have the closest acoustic values to tissue, mechanical properties
are limited, and strict storage protocols must be employed to counteract dehydration
and microbial growth. Polyvinyl chloride (PVC) has superior mechanical properties
and is a suitable alternative if durability is desired and some ultrasound realism
to human tissue may be sacrificed. Polyvinyl alcohol (PVA), while also requiring hydration,
performs well across all categories. Furthermore, we propose a framework for the evaluation
of future ultrasound-guided needle intervention tissue phantoms to increase the fidelity
of training programs and thereby improve clinical performance.
Key Words
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Ultrasound in Medicine and BiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Deliberate practice using validated metrics improves skill acquisition in performance of ultrasound-guided peripheral nerve block in a simulated setting.J Clin Anesth. 2018; 48: 22-27
- Methods for specifying acoustic properties of tissue mimicking phantoms and objects.AIUM Technical Standards Committee, Stage I. Laurel, MD1995
- Development of a tailored thyroid gland phantom for fine-needle aspiration cytology by three-dimensional printing.J Surg Educ. 2017; 74: 1039-1046
- The acoustic properties, centered on 20 MHz, of an IEC agar-based tissue-mimicking material and its temperature, frequency and age dependence.Ultrasound Med Biol. 2008; 34: 1292-1306
- Assessment of the acoustic properties of common tissue-mimicking test phantoms.Ultrasound Med Biol. 2003; 29: 1053-1060
- Pilot investigation into the use of an anthropomorphic breast sonography phantom as a training and assessment tool.Ultrasound Med Biol. 2017; 43: 2733-2740
- Use of novel anthropomorphic breast ultrasound phantoms for radiology resident education.J Am Coll Radiol. 2019; 16: 211-218
- Characterization of tissue-simulating phantom materials for ultrasound-guided needle procedures.in: Holmes III, DR Wong KH Proc SPIE 8316, Medical Imaging 2012: Image-guided procedures, robotic interventions, and modeling. 83262B, 2012 (17 February)
- Acoustic and elastic properties of glycerol in oil-based gel phantoms.Ultrasound Med Biol. 2017; 43: 2086-2094
- Tuning acoustic and mechanical properties of materials for ultrasound phantoms and smart substrates for cell cultures.Acta Biomater. 2017; 49: 368-378
- Novel tissue mimicking materials for high frequency breast ultrasound phantoms.Ultrasound Med Biol. 2011; 37: 122-135
- Multilayered tissue mimicking skin and vessel phantoms with tunable mechanical, optical, and acoustic properties.Med Phys. 2016; 43: 3117-3131
- Conventional medical education and the history of simulation in radiology.Acad Radiol. 2015; 22: 1252-1267
- Assessment of the accuracy of an ultrasound elastography liver scanning system using a PVA–cryogel phantom with optimal acoustic and mechanical properties.Phys Med Biol. 2010; 55: 5965-5983
- A review of tissue substitutes for ultrasound imaging.Ultrasound Med Biol. 2010; 36: 861-873
- Polyvinyl chloride plastisol breast phantoms for ultrasound imaging.Ultrasonics. 2016; 70: 98-106
- PVA matches human liver in needle-tissue interaction.J Mech Behav Biomed Mater. 2017; 69: 223-228
- Development and preliminary evaluation of an anthropomorphic trans-rectal ultrasound prostate brachytherapy training phantom.Ultrasound Med Biol. 2021; 47: 833-846
- Use of a novel anthropomorphic prostate simulator in a prostate brachytherapy transrectal ultrasound imaging workshop for medical physicists.Phys Med. 2022; 95: 156-166
- Physical properties of tissues.Academic Press, London1990: 73-135
- Simulation training in central venous catheter insertion: improved performance in clinical practice.Acad Med. 2010; 85: 1462-1469
- In vitro indentation to determine the mechanical properties of epidermis.J Biomech. 2011; 44: 1176-1181
- Percutaneous vascular cannulation for extracorporeal life support (ECLS): A modified technique.Int J Artif Organs. 2010; 33: 553-557
- The relative contributions of different skin layers to the mechanical behavior of human skin in vivo using suction experiments.Med Eng Phys. 2006; 28: 259-266
- A realistic deformable prostate phantom for multimodal imaging and needle-insertion procedures.Med Phys. 2012; 39: 2031-2041
- Introduction: Feature issue on phantoms for the performance evaluation and validation of optical medical imaging devices.Biomed Opt Express. 2012; 3: 1399-1403
- Fabrication and characterization of tissue-mimicking phantoms for ultrasound-guided cannulation training.ASAIO J. 2022; 68: 940-948
- PVA hydrogel properties for biomedical application.J Mech Behav Biomed Mater. 2011; 4: 1228-1233
- Experimental study of needle–tissue interaction forces: Effect of needle geometries, insertion methods and tissue characteristics.J Biomech. 2014; 47: 3344-3353
- Stiffness and anisotropy effect on shear wave elastography: A phantom and in vivo renal study.Ultrasound Med Biol. 2020; 46: 34-45
- Polyvinyl chloride as a multimodal tissue-mimicking material with tuned mechanical and medical imaging properties.Med Phys. 2016; 43: 5577-5592
- Anthropomorphic breast phantoms for testing elastography systems.Ultrasound Med Biol. 2006; 32: 857-874
- Extra corporeal membrane oxygenation (ECMO) review of a lifesaving technology.J Thorac Dis. 2015; 7: E166-E176
- Indentation versus tensile measurements of Young's modulus for soft biological tissues.Tissue Eng Part B Rev. 2011; 17: 155-164
- Tissue-mimicking materials for teaching sonographers and evaluation of their specifications after three years.Ultrasound Med Biol. 2001; 27: 1713-1716
- Ultrasonic propagation properties of excised human skin.Ultrasound Med Biol. 1995; 21: 1177-1190
- A realistic phantom for ultrasound-guided central venous cannulation. Paper No. DMD2020-9007.in: 2020 Design of Medical Devices Conference. Minneapolis, MN, USA, 2020 (April 6–9)
- Force modeling for needle insertion into soft tissue.IEEE Trans Biomed Eng. 2004; 51: 1707-1716
- In vivo measurements of the elastic mechanical properties of human skin by indentation tests.Med Eng Phys. 2008; 30: 599-606
- An affordable and easily constructed model for training in ultrasound-guided vascular access.J Vasc Access. 2015; 16: 422-427
- Pitfalls in percutaneous ECMO cannulation.Heart Lung Vessel. 2015; 7: 320-326
- Evaluating the introduction of extracorporeal life support technology to a tertiary-care pediatric institution: Smoothing the learning curve through interprofessional simulation training.J Pediatr Surg. 2015; 50: 798-804
- Extracorporeal life support for adult cardiopulmonary failure.Best Pract Res Clin Anaesthesiol. 2015; 29: 229-239
- A comparison of homemade vascular access ultrasound phantom models for peripheral intravenous catheter insertion.J Vasc Access. 2021; 22: 891-897
- The speed of sound and attenuation of an IEC agar-based tissue-mimicking material for high frequency ultrasound applications.Ultrasound Med Biol. 2012; 38: 1262-1270
- Skin thickness measurement by pulsed ultrasound; its reproducibility, validation and variability.Br J Dermatol. 1982; 106: 657-667
- Characterization of various tissue mimicking materials for medical ultrasound imaging.in: Kontos D Flohr TG SPIE Proceedings Vol. 9783. Medical imaging. Physics of medical imaging, 2016
- Silicone-based composite materials simulate breast tissue to be used as ultrasonography training phantoms.Ultrasonics. 2018; 88: 9-15
- Needle–tissue interaction forces—A survey of experimental data.Med Eng Phys. 2012; 34: 665-680
- Paraffin-gel tissue-mimicking material for ultrasound-guided needle biopsy phantom.Ultrasound Med Biol. 2013; 39: 2477-2484
- Biologically relevant photoacoustic imaging phantoms with tunable optical and acoustic properties.J Biomed Opt. 2016; 21101405
- Silicone-based tissue-mimicking phantom for needle insertion simulation.J Med Devices. 2014; 8021001
- The role of phantoms and simulation in teaching ultrasound skills in emergency medicine.in: Connolly JA Dean AJ Hoffman B Jarman RD Emergency point-of-care ultrasound. 2nd ed. Wiley, New York2017: 479-486
- The polony phantom: A cost-effective aid for teaching emergency ultrasound procedures.Int J Emerg Med. 2010; 3: 115-118
Article info
Publication history
Published online: October 07, 2022
Accepted:
July 30,
2022
Received in revised form:
July 7,
2022
Received:
February 10,
2022
Identification
Copyright
© 2022 World Federation for Ultrasound in Medicine & Biology. All rights reserved.