Abstract
This study was aimed at determining whether liver stiffness measurements by 2-D shear
wave elastography using GE's (2D-SWE-GE) and Canon's (2D-SWE-Canon) newest apparatus
and vibration-controlled transient elastography (VCTE) share the same distribution
of values compared with Hologic Supersonic Imagine (2D-SWE-SSI). In participants with
chronic liver disease recruited in two university centers from August 2020 to February
2021, liver stiffness was measured the same day by the same operator with 2D-SWE-SSI
plus one of the following devices: 2D-SWE-GE (n = 314), 2D-SWE-Canon (n = 311), and
VCTE-M probe (n = 812). VCTE-M and 2D-SWE-SSI values shared the highest correlation
and concordance coefficients (0.933 and 0.920, respectively) and a coefficient of
variation below 20%, whatever the range of values. 2D-SWE-GE had the lowest variations,
with 2D-SWE-SSI values below 13 kPa. However, both 2D-SWE-GE and 2D-SWE-Canon exhibited
a frank underestimation of the high percentiles’ 2D-SWE-SSI values with coefficients
of variation of –21.7% and –25.8% from 13- to 17-kPa values, and –44.3% and –32.4%
from 17-kPa values, respectively. In conclusion, knowledge of the vendor-specific
distribution of values is mandatory for interpreting results obtained with different
machines. If all four techniques behave closely in low values allowing excluding advanced
chronic liver diseases in larger populations, discrepancies are observed in high percentile
values.
Graphical abstract
Graphical Abstract
Key Words
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Article info
Publication history
Published online: August 29, 2022
Accepted:
June 24,
2022
Received in revised form:
May 26,
2022
Received:
February 25,
2022
Identification
Copyright
© 2022 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
