Abstract
The purpose of this study was to assess the utility of 2-D shear wave elastography
(SWE) in assessing liver fibrosis in patients with chronic liver disease by comparing
its performance with that of point shear wave elastography (pSWE) using liver histological
staging as the reference standard. In this ethics committee-approved, single-institution
prospective study, pSWE and 2-D SWE velocity measurements were obtained in 121 adult
patients (age: 18–70 y, median: 45 y) immediately before a liver biopsy for chronic
liver disease. Shear wave velocity (SWV) and Ishak scores were compared using the
Kruskal–Wallis test, Spearman's correlation and receiver operating characteristic
(ROC) curve analysis. Youden's index was used to determine the optimal cutoff point.
There was no technical failure using pSWE and 2-D SWE. The mean difference for SWV
between pSWE and 2-D SWE was 0.0223 (limits of agreement: –1.1009, 1.1145). Values
for both pSWE and 2-D SWE were significantly correlated with fibrosis stage (Spearman's
ρ = 0.606, p < 0.0001; ρ = 0.722, p < 0.001 respectively). The area under the ROC curve differentiating F ≥3 was 0.855 (95% confidence interval: 0.778–0.932) for pSWE and 0.884 (95% CI: 0.817–0.951)
for 2-D SWE. The AUC for differentiating F ≥5 was 0.890 (95% CI: 0.826–0.954) for pSWE and 0.926 (95% CI: 0.88–0.973) for 2-D
SWE. This study indicates that 2-D SWE provides feasible and accurate assessment of
liver fibrosis, comparable to that provided by pSWE from two different manufacturers’
machines.
Key Words
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Article info
Publication history
Published online: August 23, 2022
Accepted:
June 12,
2022
Received in revised form:
May 4,
2022
Received:
November 15,
2021
Identification
Copyright
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