Abstract
After establishment of an animal model of atherosclerosis, speckle tracking imaging
was performed to analyze the correlation between ultrasound characteristics and pathological
manifestations. Rabbits were divided into the normal control (NC) and atherosclerosis
(AS) groups. Rabbits in the AS group were subjected to ultrasound-guided balloon injury
of the abdominal aorta and fed a high-fat diet for 16 wk. Rabbits in the NC group
were fed a normal diet for the same period. After 16 wk, all animals underwent serological
tests, ultrasound and speckle tracking circumferential strain analysis. In the AS
group, 28 hypo-echoic plaques had formed. The circumferential strain of six segments
at the short axis of plaques in the AS group was lower than that in the NC group (p < 0.001), and global circumferential strain (GCS) in the AS group was significantly
reduced compared with the NC group (p < 0.001). In the AS group, the area ratio of type I to type III collagen fibers was
smaller than that in the NC group. The GCS of atherosclerotic plaques was positively
correlated with the area ratio of type I to type III collagen fibers in plaques (r = 0.7181, p < 0.001). In conclusion, there is a significant positive correlation between the
decreased circumferential strain and the decreased area ratio of type I to type III
collagen fibers in hypo-echoic plaques.
Key Words
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Ultrasound in Medicine and BiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- The association between metabolic syndrome components and the development of atherosclerosis.J Hum Hypertens. 2019; 33: 844-855
- The effect of adropin on lipid and glucose metabolism in rats with hyperlipidemia.Iran J Basic Med Sci. 2016; 19: 245-251
- Macrophage uptake switches on OCT contrast of superparamagnetic nanoparticles for imaging of atherosclerotic plaques.Int J Nanomed. 2018; 13: 7905-7913
- Rabbit models to study atherosclerosis and its complications—Transgenic vascular protein expression in vivo.Prog Biophys Mol Biol. 2016; 121: 131-141
- Attenuated plaque at nonculprit lesions in patients enrolled in intravascular ultrasound atherosclerosis progression trials.JACC Cardiovasc Interv. 2009; 2: 672-678
- Quantitative assessment of carotid plaque morphology (geometry and tissue composition) using computed tomography angiography.J Vasc Surg. 2019; 70: 858-868
- 18F-FDG uptake on PET/CT in symptomatic versus asymptomatic carotid disease: A meta-analysis.Eur J Vasc Endovasc Surg. 2018; 56: 172-179
- Mixed reality navigation system for ultrasound-guided percutaneous punctures: A pre-clinical evaluation.Surg Endosc. 2020; 34: 226-230
- Association between serum uric acid level and carotid atherosclerosis in Chinese individuals aged 75 years or older: A hospital-based case–control study.J Nutr Health Aging. 2018; 22: 508-512
- Pulse wave analysis and diabetes mellitus: A systematic review.Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017; 161: 223-233
- Functional regulatory roles of microRNAs in atherosclerosis.Clin Chim Acta. 2016; 460: 164-171
- Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome.J Intern Med. 2020; 287: 493-513
- Molecular biology of atherosclerosis.Physiol Rev. 2013; 93: 1317-1542
- Novel ultrasound methods to investigate carotid artery plaque vulnerability.J Am Soc Echocardiogr. 2017; 30: 139-148
- Soluble uric acid promotes atherosclerosis via AMPK (AMP-activated protein kinase)-mediated inflammation.Arterioscler Thromb Vasc Biol. 2020; 40: 570-582
- Atherosclerosis.Circ Res. 2018; 123: 1118-1120
- Diabetes mellitus, arterial stiffness and cardiovascular disease: Clinical implications and the influence of SGLT2i.Curr Vasc Pharmacol. 2020; 18: 1-8
- Ultrasound speckle tracking for radial, longitudinal and circumferential strain estimation of the carotid artery—An in vitro validation via sonomicrometry using clinical and high-frequency ultrasound.Ultrasonics. 2015; 56: 399-408
- Atherosclerosis.Nat Rev Dis Primers. 2019; 5: 56
- The association of lesion eccentricity with plaque morphology and components in the superficial femoral artery: A high-spatial-resolution, multi-contrast weighted CMR study.J Cardiovasc Magn Reson. 2010; 12: 37
- Utility of complementary magnetic resonance plaque imaging and contrast-enhanced ultrasound to detect carotid vulnerable plaques.J Am Heart Assoc. 2019; 8e011302
- An automated algorithm to quantify collagen distribution in aortic wall.J Histochem Cytochem. 2019; 67: 267-274
- Speckle tracking carotid artery circumferential strain is a marker of arterial sclerosis but not coronary atherosis.J Clin Ultrasound. 2018; 46: 575-581
- An ultrasonographic multiparametric carotid plaque risk index associated with cerebrovascular symptomatology: A study comparing color Doppler imaging and contrast-enhanced ultrasonography.AJNR Am J Neuroradiol. 2019; 40: 1022-1028
- A comparative study of color Doppler imaging and contrast-enhanced ultrasound for the detection of ulceration in patients with carotid atherosclerotic disease.Eur Radiol. 2019; 29: 2137-2145
- Imaging biomarkers of vulnerable carotid plaques for stroke risk prediction and their potential clinical implications.Lancet Neurol. 2019; 18: 559-572
- Hultgårdh-Nilsson A. Collagen and related extracellular matrix proteins in atherosclerotic plaque development.Curr Opin Lipidol. 2014; 25: 394-399
- Atherosclerosis in rabbits fed a low cholesterol diet for five years.Arteriosclerosis. 1982; 2: 228-241
- A discrete mesoscopic particle model of the mechanics of a multi-constituent arterial wall.J R Soc Interface. 2016; 1320150964
- Association of high serum uric acid and increased arterial stiffness is dependent on cardiovascular risk factors in female population.Horm Metab Res. 2019; 51: 367-374
- Advanced ultrasound methods in assessment of carotid plaque instability: A prospective multimodal study.BMC Neurol. 2020; 20: 39
- Icaritin inhibits collagen degradation-related factors and facilitates collagen accumulation in atherosclerotic lesions: A potential action for plaque stabilization.Int J Mol Sci. 2016; 17: 169
- Association between blood glucose variability and the. characteristics of vulnerable plaque in elderly non-ST segment elevation acute coronary syndrome patients.Int Heart J. 2019; 60: 569-576
- Predictive value of fasting blood glucose for serious coronary atherosclerosis in non-diabetic patients.J Int Med Res. 2019; 47: 152-158
Article info
Publication history
Published online: August 08, 2022
Accepted:
May 22,
2022
Received in revised form:
May 5,
2022
Received:
February 2,
2022
Identification
Copyright
© 2022 Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biology.
