Abstract
Neither contrast-enhanced computed tomography nor magnetic resonance imaging can monitor
changes in the pancreatic ductal adenocarcinoma microenvironment during therapy. We
hypothesized that shear wave elastography could overcome this limitation. To test
this hypothesis, we measured the shear modulus of two groups of murine pancreatic
tumors (KCKO, n = 30; PAN02, n = 30) treated with stereotactic body radiation therapy
(SBRT). The mean shear modulus of KCKO tumors was 7.651 kPa higher than that of PAN02
tumors (p < 0.001). SBRT reduced the shear modulus in KCKO tumors by 8.914 kPa (p < 0.001). No significant difference in the shear modulus of SBRT-treated PAN02 tumors
was observed. Additionally, necrotic and collagen densities were reduced only in the
SBRT-treated KCKO tumors. Shear modulus was dependent on collagen distribution and
histological texture parameters (i.e., entropy and fractional dimension). Shear wave elastography imaging differentiates
between SBRT-responsive (KCKO) and non-responsive (PAN02) tumors.
Key Words
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Article info
Publication history
Published online: November 11, 2019
Accepted:
October 9,
2019
Received in revised form:
October 1,
2019
Received:
August 21,
2019
Identification
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