Abstract
Longitudinal kinetics (LOKI) of the arterial wall consists of the shearing motion
of the intima–media complex over the adventitia layer in the direction parallel to
the blood flow during the cardiac cycle. The aim of this study was to investigate
the local variability of LOKI amplitude along the length of the vessel. By use of
a previously validated motion-estimation framework, 35 in vivo longitudinal B-mode ultrasound cine loops of healthy common carotid arteries were
analyzed. Results indicated that LOKI amplitude is progressively attenuated along
the length of the artery, as it is larger in regions located on the proximal side
of the image (i.e., toward the heart) and smaller in regions located on the distal side of the image
(i.e., toward the head), with an average attenuation coefficient of −2.5 ± 2.0%/mm. Reported
for the first time in this study, this phenomenon is likely to be of great importance
in improving understanding of atherosclerosis mechanisms, and has the potential to
be a novel index of arterial stiffness.
Key Words
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Article info
Publication history
Published online: October 21, 2014
Accepted:
July 27,
2014
Received in revised form:
June 14,
2014
Received:
February 25,
2014
Identification
Copyright
© 2015 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
