Abstract
This study evaluated the use of ultrasound in combination with the commercial anti-inflammatory
drugs ketoprofen and sodium diclofenac, according to the parameters used in physiotherapy.
Ketoprofen and sodium diclofenac were used in the Franz diffusion cell model adapted
to an ultrasound transducer in three conditions: no ultrasound, one application of
ultrasound and two applications of ultrasound. High-performance liquid chromatography
was used to quantify the total amount of drug permeating skin per unit area, as well
as flux and latency. The results showed that for ketoprofen, the amount of drug permeating
skin and flux increased with two ultrasound applications. Permeation of sodium diclofenac
decreased in the presence of ultrasound. Ultrasound parameters and drug properties
must be considered in the use of phonophoresis.
Key Words
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Article info
Publication history
Published online: July 01, 2013
Accepted:
February 16,
2013
Received in revised form:
February 15,
2013
Received:
July 18,
2012
Identification
Copyright
© 2013 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
