Advertisement

A New Visually Evoked Cerebral Blood Flow Response Analysis Using a Low-Frequency Estimation

      Abstract

      Transcranial Doppler (TCD) has been widely used to monitor cerebral blood flow velocity (BFV) during the performance of cognitive tasks compared with repose periods. Although one of its main advantages is its high temporal resolution, only some of the previous functional TCD studies have focused on the analysis of the temporal evolution of the BFV signal and none of them has performed a spectral analysis of the signal. In this study, maximum BFV data in both posterior cerebral arteries was monitored during a visual perception task (10 cycles of alternating darkness and illumination) for 23 subjects. A peak was located in the low-frequency band of the spectrum of the maximum BFV of each subject both during visual stimulation and repose periods. The frequency of this peak was in the range between 0.037 and 0.098 Hz, depending on the subject, the vessel and the experimental condition. The component of the signal at this frequency, which is associated with the slow variations caused by the visual stimuli, was estimated. That way, the variations in BFV caused by the experimental stimuli were isolated from the variations caused by other factors. This low-frequency estimation signal was used to obtain parameters about the temporal evolution and the magnitude variations of the BFV in a reliable way, thus, characterizing the neurovascular coupling of the participants. (E-mail: [email protected] )

      Key Words

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Ultrasound in Medicine and Biology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Aaslid R.
        Visually evoked dynamic blood flow response of the human cerebral circulation.
        Stroke. 1987; 18: 771-775
        • Aaslid R.
        • Markwalder T.M.
        • Nornes H.
        Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries.
        J Neurosurg. 1982; 57: 769-774
        • Azevedo E.
        • Rosengarten B.
        • Santos R.
        • Freitas J.
        • Kaps M.
        Interplay of cerebral autoregulation and neurovascular coupling evaluated by functional TCD in different orthostatic conditions.
        J Neurol. 2007; 254: 236-241
        • Daffertshofer M.
        Functional Doppler testing.
        in: Hennerici M.G. Meairs S.P. Cerebrovascular ultrasound: Theory, practice and future development. 1st edition. Cambridge University Press, Cambridge2001
        • Deppe M.
        • Knecht S.
        • Henningsen H.
        • Ringelstein E.B.
        Average: A windows program for automated analysis of event related cerebral blood flow.
        J Neurosci Methods. 1997; 75: 147-154
        • Deppe M.
        • Ringelstein E.B.
        • Knecht S.
        The investigation of functional brain lateralization by transcranial Doppler sonography.
        Neuroimage. 2004; 21: 1124-1146
        • Duschek S.
        • Schandry R.
        Functional transcranial Doppler sonography as a tool in psychophysiological research.
        Psychophysiology. 2003; 40: 436-454
        • Gomez S.M.
        • Gomez C.R.
        • Hall I.S.
        Transcranial Doppler ultrasonographic assessment of intermittent light stimulation at different frequencies.
        Stroke. 1990; 21: 1746-1748
        • Harders A.G.
        • Laborde G.
        • Droste D.W.
        • Rastogi E.
        Brain activity and blood flow velocity changes: A transcranial Doppler study.
        Int J Neurosci. 1989; 47: 91-102
        • Iadecola C.
        Regulation of the cerebral microcirculation during neural activity: Is nitric oxide the missing link?.
        Trends Neurosci. 1993; 16: 206-214
        • Kelley R.E.
        • Chang J.Y.
        • Scheinman N.J.
        • Levin B.E.
        • Duncan R.C.
        • Lee S.C.
        Transcranial Doppler assessment of cerebral flow velocity during cognitive tasks.
        Stroke. 1992; 23: 9-14
        • Knecht S.
        • Drager B.
        • Deppe M.
        • Bobe L.
        • Lohmann H.
        • Floel A.
        • Ringelstein E.B.
        • Henningsen H.
        Handedness and hemispheric language dominance in healthy humans.
        Brain. 2000; 123: 2512
        • Knecht S.
        • Henningsen H.
        • Deppe M.
        • Huber T.
        • Ebner A.
        • Ringelstein E.B.
        Successive activation of both cerebral hemispheres during cued word generation.
        Neuro Report. 1996; 7: 820
        • Kuo T.B.J.
        • Chern C.M.
        • Sheng W.Y.
        • Wong W.J.
        • Hu H.H.
        Frequency domain analysis of cerebral blood flow velocity and its correlation with arterial blood pressure.
        J Cereb Blood Flow Metab. 1998; 18: 311-318
        • Martens E.
        • Peeters L.L.H.
        • Gommer E.D.
        • Mess W.H.
        • van de Vosse F.N.
        • Passos V.L.
        • Reulen J.P.H.
        The Visually-Evoked cerebral blood flow response in women with a recent history of preeclampsia and/or eclampsia.
        Ultrasound Med Biol. 2009; 35: 1-7
        • Matteis M.
        • Caltagirone C.
        • Troisi E.
        • Vernieri F.
        • Monaldo C.
        • Silvestrini M.
        Changes in cerebral blood flow induced by passive and active elbow and hand movements.
        J Neurol. 2001; 248: 104-108
      1. Naranjo V. 2002. Técnicas de análisis de secuencias de vídeo - aplicación a la restauración de películas antiguas. Ph.D. Thesis, ETSI Telecomunicación. Universidad Politécnica de Valencia, Valencia.

      2. Naranjo V, Albiol A. Flicker reduction in old films. In: Billene Mercer and Conference Management Services, eds. Proceedings of the International Conference of Image Processing 2000. Vancouver, Canada: The Institute of Electrical and Electronics Engineers, Inc., 2000. pp. 657–659.

        • Njemanze P.C.
        • Gomez C.R.
        • Horenstein S.
        Cerebral lateralization and color perception: a transcranial Doppler study.
        Cortex. 1992; 28: 69-75
        • Oldfield R.C.
        The assessment and analysis of handedness: The Edinburgh inventory.
        Neuropsychologia. 1971; 9: 97-113
        • Oppenheim A.V.
        • Schafer R.W.
        Discrete-time signal processing.
        Prentice-Hall, Inc, Upper Saddle River, NJ1989
        • Orlandi G.
        • Murri L.
        Transcranial Doppler assessment of cerebral flow velocity at rest and during voluntary movements in young and elderly healthy subjects.
        Int J Neurosci. 1996; 84: 45-53
        • Rihs F.
        • Gutbrod K.
        • Gutbrod B.
        • Steiger H.J.
        • Sturzenegger M.
        • Mattle H.P.
        Determination of cognitive hemispheric dominance by stereo transcranial Doppler sonography.
        Stroke. 1995; 26: 70-73
        • Ringelstein E.
        • Kahlscheuer B.
        • Niggemeyer E.
        • Otis S.
        Transcranial Doppler sonography: Anatomical landmarks and normal velocity values.
        Ultrasound Med Biol. 1990; 16: 745-761
        • Risberg J.
        Regional cerebral blood flow in neuropsychology.
        Neuropsychologia. 1986; 24: 135
        • Rosengarten B.
        • Huwendiek O.
        • Kaps M.
        Neurovascular coupling in terms of a control system: Validation of a second-order linear system model.
        Ultrasound Med Biol. 2001; 27: 631
        • Schnittger C.
        • Johannes S.
        • Arnavaz A.
        • Munte T.F.
        Blood flow velocity changes in the middle cerebral artery induced by processing of hierarchical visual stimuli.
        Neuropsychologia. 1997; 35: 1181-1184
        • Sitzer M.
        • Diehl R.R.
        • Hennerici M.
        Visually evoked cerebral blood flow responses: Normal and pathological conditions.
        J Neuroimaging. 1992; 2: 65-70
        • Stroobant N.
        • Vingerhoets G.
        Transcranial Doppler ultrasonography monitoring of cerebral hemodynamics during performance of cognitive tasks: A review.
        Neuropsychol Rev. 2000; 10: 213-231
        • Sturzenegger M.
        • Newell D.W.
        • Aaslid R.
        Visually evoked blood flow response assessed by simultaneous two-channel transcranial Doppler using flow velocity averaging.
        Stroke. 1996; 27: 2256-2261
        • Trkanjec Z.
        • Demarin V.
        Hemispheric asymmetries in blood flow during color stimulation.
        J Neurol. 2007; 254: 861-865
        • van Drongelen W.
        Signal processing for neuroscientists: Introduction to the analysis of physiological signals.
        Academic Press, Amsterdam2006
        • Vingerhoets G.
        • Berckmoes C.
        • Stroobant N.
        Cerebral hemodynamics during discrimination of prosodic and semantic emotion in speech studied by transcranial Doppler ultrasonography.
        Neuropsychology. 2003; 17: 93-99
        • Vingerhoets G.
        • Stroobant N.
        Lateralization of cerebral blood flow velocity changes during cognitive tasks. A simultaneous bilateral transcranial Doppler study.
        Stroke. 1999; 30: 2152-2158