Abstract
To derive the optimal cutting planes of real-time 3-D echocardiography (RT-3DE) for
measuring left ventricular volume and ejection fraction (EF) in the presence of left
ventricular regional wall motion abnormalities, 14 open-chest dogs were studied with
RT-3DE full volume imaging and 2-D echocardiography (2DE) after left anterior descending
coronary arteries were occluded for 90 min. Left ventricular end diastolic volume
(EDV), end systolic volume (ESV), stroke volume (SV) and EF were measured off-line
with 2DE and RT-3DE (2-, 4- and 8-plane) methods. The autopsy EDV was estimated by
the volume of saline solution injected into the excised heart and served as the reference
volume (RefV) for comparison with EDV measured by 2DE and RT-3DE. Agreement analysis
was performed according to the method of Bland and Altman. There were excellent correlations
between 2DE, RT-3DE (2-plane) and RT-3DE (4-plane) methods on one hand, and RT-3DE
(8-plane) method on the other in the measurements of EDV, ESV and SV (r = 0.84–0.99).
However, 2DE and RT-3DE (2-plane) measurements significantly underestimated RT-3DE
(8-plane) (p < 0.01), whereas no significant differences between RT-3DE (4-plane) and RT-3DE (8-plane)
were found in terms of EDV, ESV and SV measurements. The values of EF determined by
2DE, RT-3DE (2-plane) and RT-3DE (4-plane) methods correlated highly with that by
RT-3DE (8-plane) (r = 0.82–0.98) and there was no significant difference between the
two measurements. EDV values determined by 2DE, RT-3DE (2-plane), RT-3DE (4-plane)
and RT-3DE (8-plane) correlated highly with RefV (r = 0.84, r = 0.92, r = 0.94 and
r = 0.97, respectively) and there was no significant difference between RefV and EDV
by RT-3DE (4-plane) and RT-3DE (8-plane). In contrast, EDV measured by 2DE and RT-3DE
(2-plane) methods underestimated RefV significantly (p < 0.01). In conclusion, RT-3DE allows reliable and reproducible measurement of left
ventricular volume and EF, even in the presence of left ventricular regional wall
motion abnormalities. RT-3DE (4-plane) is the method of choice for an accurate and
timesaving quantification of left ventricular volume and function. (E-mail: [email protected])
Key Words
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Article info
Publication history
Published online: June 14, 2007
Accepted:
April 25,
2007
Received in revised form:
April 18,
2007
Received:
November 3,
2006
Identification
Copyright
© 2007 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
