Abstract
The purpose of this study is to investigate the correlation between surgicopathological
findings and ultrasonic images of nonpalpable breast lesions. The study was composed
of 220 nonpalpable breast lesions from 193 patients. The breast lesions were classified
into soft tissue type (185 lesions) and calcification type (35 lesions). Of the 220
lesions, 62 (28%) were malignant. For soft tissue type lesions, the sonographic features
of sound attenuation (p < 0.001) and irregular border (p < 0.001) were significantly associated with the malignant diagnosis. For soft tissue-type
and calcification-type lesions, the presence of increased vascularity (p < 0.001) or calcification (p < 0.001) was significantly associated with the malignant diagnosis. Of the 164 breast
lesions with corresponding mammograms, 37 of 74 mammographically identifiable lesions
were pathologically malignant, as compared with 16 of 90 lesions with negative mammograms
(p < 0.001). In our study, the more sensitive sonographic features for predicting malignancy
were irregular border and increased vascularity (sensitivity 88% and 82%, respectively),
whereas the features of sound attenuation and presence of calcifications were more
specific (specificity 88% and 80%, respectively). In conclusion, ultrasound-guided
wire localization of breast lesions is not only useful in assisting surgical biopsy,
but the sonographic findings obtained by this procedure correlate with pathologic
diagnosis. (E-mail: [email protected])
Key Words
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Ultrasound in Medicine and BiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings.Ultrasound Med Biol. 1990; 16: 553-556
- Breast sonography.AJR Am J Roentgenol. 1991; 156: 449-455
- Incidental findings on sonography of the breast: clinical significance and diagnostic workup.AJR Am J Roentgenol. 1999; 173: 921-927
- Clinically and mammographically occult breast lesions: detection and classification with high-resolution sonography.Seminar in Ultrasound, CT, and MRI. 2000; 21: 325-336
- Sonographic evaluation of clinically palpable breast cancers invisible on mammography.The Breast J. 2000; 6: 247-251
- Malignant breast masses detected only by ultrasound.Cancer. 1995; 76: 626-630
- Ultrasound for breast cancer screening and staging.Radiol Clin N Am. 2002; 40: 431-441
- Ultrasound demonstration of mammographically detected microcalcifications.Acta Radiol. 2000; 41: 217-221
- New signs of breast cancer: high resistance flow and variations in resistive indices evaluation by color Doppler sonography.Ultrasound Med Biol. 1997; 23: 851-856
- Prebiopsy needle localization: methods, problems, and expected results.Radiol Clin N Am. 1992; 30: 139-153
- Microcalcifications of non-palpable breast lesions detected by ultrasonography: correlation with mammography and histopathology.Ultrasound Obstet Gynecol. 1999; 13: 431-436
- Imaging of the radiographically dense breast.Radiology. 1993; 188: 297-301
- Microbubble contrast agent for color Doppler US: effect on breast masses.Radiology. 1996; 198: 679-686
- Occult cancer in women with dense breasts: detection with screening US – diagnostic yield and tumor characteristics.Radiology. 1998; 207: 191-199
- Evaluation of solid breast lesions with power Doppler sonography.J Clin Ultrasound. 1999; 27: 231-237
- Percutaneous image-guided core breast biopsy.Radiol Clin N Am. 2002; 40: 483-500
- Color Doppler and duplex flow analysis for classification of breast lesions.Gynecol Oncol. 1997; 64: 392-403
- Color Doppler sonography in the evaluation of palpable breast mass.AJR Am J Roentgenol. 1993; 161: 765-771
- Current uses of ultrasound in the evaluation of the breast.Radiol Clin N Am. 2003; 41: 841-856
- Occult breast abnormalities: percutaneous preoperative needle localization.Radiology. 1984; 150: 335-337
- US-guided automated large core breast biopsy.Radiology. 1993; 187: 507-511
- The use of colour-coded and spectral Doppler ultrasound in the differentiation of benign and malignant breast lesions.Br J Cancer. 1995; 71: 137-139
- Ultrasound demonstration of small breast cancers detected by mammographic screening.Clin Radiol. 1994; 47: 337-338
- Benign versus malignant solid breast masses: US differentiation.Radiology. 1999; 213: 889-894
- Ultrasound in the detection of breast cancer associated with isolated clustered microcalcifications, mammographically identified.Anticancer Res. 1997; 17: 2831-2836
- Solid breast lesions: evaluation with power Doppler US.Radiology. 1997; 203: 164-168
- High-resolution sonography of breast carcinoma.Eur J Radiol. 1997; 24: 11-19
- Reducing the cost of diagnosis of breast carcinoma: impact of ultrasound and imaging-guided biopsies on a clinical breast practice.Cancer. 2001; 91: 324-332
- Mammographic detectability of breast microcalcifications.AJR Am J Roentgenol. 1982; 139: 913-918
- Analysis of sonographic features in the differentiation of fibroadenoma and invasive ductal carcinoma.AJR Am J Roentgenol. 1998; 170: 109-114
- Solid breast nodules: use of sonography to distinguish between benign and malignant lesions.Radiology. 1995; 196: 123-134
- Preoperative ultrasound- guided wire-localization of nonpalpable solid breast lesions.Chin J Radiol. 1991; 16: 321-325
- Ultrasound detection of non-palpable non-mammographically visible breast cancer [abstract].J Ultrasound Med. 1995; 15: 117
- Diagnosis of breast cancer: contribution of US as an adjunct to mammograhpy.Radiology. 1999; 213: 413-422
- Ultrasound variables and their prognostic value in a population of 1103 patients with 272 breast cancers.Eur Radiol. 2000; 10: 1562-1568
Article info
Publication history
Accepted:
May 19,
2006
Received in revised form:
May 11,
2006
Received:
October 2,
2005
Identification
Copyright
© 2006 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
