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Tumor irradiation with intense ultrasound

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      Abstract

      Tumors implanted in the hamster flank have been irradiated in vivo with intense focused ultrasound at a spatial peak intensity of 907 W/cm2. A matrix of points was irradiated under c.w. conditions through the central plane of the tumor and perpendicular to the longitudinal axis of the sound field. A center spacing of 4 mm between matrix points and a time-on period of 2.5 sec at each point produced no cures. A spacing distance of 2 mm with 7 sec time-on period at each point increased mean survival time in non-cured animals and produced a cure rate of 29.4%. Combining the second regime of ultrasound treatment with administration of a chemotherapeutic agent (BCNU) 24 hr after irradiation did not increase mean survival time in the non-cured animals compared to the BCNU non-irradiated shams; however, the cure rate increased to 40%. Secondary tumors which were not seen in any ultrasound shams or controls were observed in all other regimes including BCNU non-irradiated shams. The incidence of secondary tumors was inversely related to the cure rate.

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      References

        • Ballantine Jr., H.T.
        • Hueter T.F.
        • Nauta W.J.H.
        • Sosa D.M.
        Focal destruction of nervous tissue by focused ultrasound: Biophysical factors influencing its application.
        J. Exp. Med. 1956; 104: 337-360
        • Bell E.
        The action of ultrasound on the mouse liver.
        J. Cellular Comp. Physiol. 1957; 50: 83-104
      1. BiCNU Carmustine (BCNU) New Product Monograph. Bristol Laboratories, Division of Bristol-Myers Co, Syracuse, New York1977
        • Burnet F.M.
        Immunological Surviellance.
        Pergamon Press, Sydney1970
        • Burov A.K.
        High intensity ultrasonic oscillations for treatment of malignant tumors in animals and man.
        Doklady Akad. Nauk. SSSR. 1956; 106: 239-241
        • Burov A.K.
        • Andreevskaya G.D.
        Action of high-intensity ultrasonic vibrations on malignant tumors of animals and man.
        Doklady Akad. Nauk. SSSR. 1956; 106: 445-448
        • Chan S.K.
        • Frizzell L.A.
        Ultrasonic thresholds for structural changes in the mammalian liver.
        in: IEEE Ultrasonics Symp. Proc. IEEE Cat. No. 77 CH1264-1SU. 1977: 153-156
        • Dunn F.
        • Fry F.J.
        Ultrasonic field measurement using the suspended ball radiometer and thermocouple probe.
        in: Reid J.M. Sikov M.R. Interaction of Ultrasound and Biological Tissues Workshop Proc. DHEW Publication (FDA) 73-8008 BRH/DBE 73-1, U. S. Government Printing Office, Washington, DC1972: 173-176
        • Dunn F.
        • Fry F.J.
        Ultrasonic threshold dosages for the mammalian central nervous system.
        IEEE Trans. Biomed. Engng BME-18. 1971; : 253-256
        • Finney D.J.
        • Latscha R.
        • Bennett B.M.
        • Hsu P.
        Tables for Testing Significance in a 2 × 2 Contingency Table.
        University Press, Cambridge1963
        • Frizzell L.A.
        • Linke C.A.
        • Carstensen E.L.
        • Fridd C.W.
        Thresholds for focal ultrasonic lesions in rabbit kidney, liver and testicle.
        IEEE Trans. Biomed. Engng BME-24. 1977; : 393-396
        • Fry F.J.
        • Erdmann W.A.
        • Johnson L.K.
        • Baird A.I.
        Ultrasonic toxicity study.
        Ultrasound Med. Biol. 1978; 3: 351-366
        • Fry W.J.
        • Mosberg Jr., W.H.
        • Barnard J.W.
        • Fry F.J.
        Production of focal destructive lesions in the central nervous system with ultrasound.
        J. Neurosurg. 1954; 11: 471-478
        • Fry W.J.
        • Dunn F.
        Ultrasonic irradiation of the central nervous system at high sound levels.
        J. Acoust. Soc. Am. 1956; 28: 129-131
        • Lele P.P.
        A simple method for production of trackless focal lesions with focused ultrasound: Physical factors.
        J. Physiol. 1962; 160: 494-512
        • Lele P.P.
        Appendix I. Cavitation and its effects on organized mammalian tissue—a summary.
        in: Fry F.J. Ultrasound: Its Applications in Medicine and Biology. Elsevier, Amsterdam1978: 737-741 (Part II)
        • Lele P.P.
        Appendix II. Thermal mechanisms in ultrasound-tissue interactions-e summary.
        in: Fry F.J. Ultrasound: Its Applications in Medicine and Biology. Elsevier, Amsterdam1978: 743-745 (Part II)
        • Linke C.A.
        • Carstensen E.L.
        • Frizzell L.A.
        • Elbadawi A.
        • Fridd C.W.
        Localized tissue destruction by high-intensity focused ultrasound.
        Arch. Surg. 1973; 107: 887-891
        • Lizzi F.L.
        • Packer A.J.
        • Coleman D.J.
        Animal studies of cataracts produced by high-intensity ultrasonic energy.
        in: Ultrasound in Medicine. Vol. 2. Plenum Press, New York1976: 525-526
        • Oka M.
        Progress in studies of the potential use of medical ultrasonics. Chapt. 3 Studies of potentiality in the surgical use of ultrasound of high intensity and of lower intensity.
        Wakayama Med. Rep. 1977; 20: 32-39
        • Rapp F.
        • Pauluzzi S.
        • Waltz T.A.
        • Burdine Jr., J.A.
        • Matsen III, F.A.
        • Levy B.
        Induction of brain tumors in newborn hamsters by simian adenovirus SA7.
        Can. Res. 1969; 29: 1173-1178
        • Thomas L.
        Discussion.
        in: Lawrence H.S. Cellular and Humoral Aspects of the Hypersensitive States. P. B. Hoeber, New York1959: 529-532
        • Wagai T.
        • Kaketa K.
        II. Medical application of intense ultrasound. 3. Destruction of malignant tumor by intense focused ultrasound.
        in: Annual Report (1970) of the Medical Ultrasonics Research Center. Juntendo University School of Medicine, Hongo, Tokyo, Japan1971: 35-59