Ultrasound in Medicine and Biology
Volume 38, Issue 3 , Pages 423-431, March 2012

High-Frequency Ultrasound in the Evaluation of Cerebral Intraventricular Haemorrhage in Preterm Rabbit Pups

  • Snjolaug Sveinsdottir

      Affiliations

    • Division of Pediatrics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden
    • Corresponding Author InformationAddress correspondence to: Snjolaug Sveinsdottir, M.D., Clinic of Neonatology, Skane University Hospital, 221 85 Lund, Sweden.
    • ,
  • Magnus Cinthio

      Affiliations

    • Electrical Measurements, Faculty of Engineering, LTH, Lund University, Lund, Sweden
    • ,
  • David Ley

      Affiliations

    • Division of Pediatrics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden

Received 6 July 2011; received in revised form 22 November 2011; accepted 3 December 2011.

Abstract 

Cerebral intraventricular haemorrhage (IVH) is the most common cause of severe neurologic impairment following preterm birth in human infants. Ideally, an animal model for cerebral IVH should allow for reliable noninvasive evaluation of haemorrhagic extension and of subsequent development of posthaemorrhagic ventricular dilatation (PHVD). The aim of this study was to evaluate the use of high-frequency ultrasound (HFU) in premature rabbit pups with cerebral IVH induced by IP glycerol injection. Serial examinations using HFU enabled an accurate description of haemorrhagic extension and measurement of progressive PHVD over 72 h. The coefficient of variation for inter- and intraobserver variability in two measurements of ventricular size was less than 8.8% and 9.3%, respectively. Repeated ultrasound-guided intraventricular injection and sampling could be performed in vivo excluding requirement of stereotactic procedures and sedation. Application of HFU is a powerful tool for the evaluation of mechanisms involved in cerebral IVH and PHVD in the preterm rabbit pup model.

Key Words: High-frequency ultrasound, Cranial ultrasound, Cerebral intraventricular haemorrhage, Posthaemorrhagic hydrocephalus

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PII: S0301-5629(11)01535-3

doi:10.1016/j.ultrasmedbio.2011.12.003

Ultrasound in Medicine and Biology
Volume 38, Issue 3 , Pages 423-431, March 2012

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