Ultrasound in Medicine and Biology
Volume 36, Issue 10 , Pages 1704-1712, October 2010

Theoretical and Experimental Study on Temperature Elevation behind Ribs Caused by Weakly Focused Ultrasound

  • Xiaozhou Liu

      Affiliations

    • Key Laboratory of Modern Acoustics, Institute of Acoustics, Nanjing University, Nanjing, People’ Republic of China
    • ,
  • Chang Yin

      Affiliations

    • Key Laboratory of Modern Acoustics, Institute of Acoustics, Nanjing University, Nanjing, People’ Republic of China
    • ,
  • Xiufen Gong

      Affiliations

    • Key Laboratory of Modern Acoustics, Institute of Acoustics, Nanjing University, Nanjing, People’ Republic of China
    • ,
  • Wenwu Cao

      Affiliations

    • Material Research Institute, The Pennsylvania State University, University Park, PA, USA
    • Corresponding Author InformationAddress correspondence to: Wenwu Cao, 164 Materials Research Lab, The Pennsylvania State University, University Park, PA 16802 USA.

Received 6 March 2010; received in revised form 11 June 2010; accepted 20 July 2010. published online 01 September 2010.

Abstract 

Temperature distribution in tissues behind ribs produced by weakly focused ultrasound had been calculated using Pennes bioheat equation and the validity of the theoretical model was experimentally confirmed in vitro using porcine live. We found that the position of the maximum temperature in tissue is strongly influenced by the distance between the transducer and ribs, while the gap between ribs is the determining factor for the maximum achievable temperature. Within the focal length, when the distance between the transducer and ribs increases, the maximum temperature increases and its position shifts away from the transducer. The rib width has little effect on the position of the maximum temperature but affects the achievable peak temperature. Our results provide useful information for treating liver cancers using ultrasound induced hyperthermia. (E-mail: dzk@psu.edu)

Key Words: Focused ultrasound, Ribs, Hyperthermia, Pennes bioheat equation

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PII: S0301-5629(10)00376-5

doi:10.1016/j.ultrasmedbio.2010.07.018

Ultrasound in Medicine and Biology
Volume 36, Issue 10 , Pages 1704-1712, October 2010

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