Ultrasound in Medicine and Biology
Volume 36, Issue 10 , Pages 1691-1703 , October 2010

Initial Investigation of Acoustic Droplet Vaporization for Occlusion in Canine Kidney

  • M. Zhang

      Affiliations

    • Department of Radiology, University of Michigan Health System, Ann Arbor, MI
    • Corresponding Author InformationAddress correspondence to: Man Zhang, M.D., Ph.D., Department of Radiology, University of Michigan Health System, 3232 Medical Sciences Building I, 1301 Catherine Street, Ann Arbor, MI 48109-5667.
    • ,
  • M.L. Fabiilli

      Affiliations

    • Department of Radiology, University of Michigan Health System, Ann Arbor, MI
    • ,
  • K.J. Haworth

      Affiliations

    • Department of Radiology, University of Michigan Health System, Ann Arbor, MI
    • ,
  • J.B. Fowlkes

      Affiliations

    • Department of Radiology, University of Michigan Health System, Ann Arbor, MI
    • ,
  • O.D. Kripfgans

      Affiliations

    • Department of Radiology, University of Michigan Health System, Ann Arbor, MI
    • ,
  • W.W. Roberts

      Affiliations

    • Department of Urology, University of Michigan Health System, Ann Arbor, MI
    • ,
  • K.A. Ives

      Affiliations

    • Department of Radiology, University of Michigan Health System, Ann Arbor, MI
    • ,
  • P.L. Carson

      Affiliations

    • Department of Radiology, University of Michigan Health System, Ann Arbor, MI

Received 24 November 2009 ,Revised 20 May 2010 ,Accepted 23 June 2010.

References 

  1. Apfel RE. Activatable infusable dispersions containing drops of a superheated liquid for methods of therapy and diagnosis. U.S. Patent 5,840,276 Apfel Enterprises, Inc.; 1998;
  2. Arima K, Yamakado K, Kinbara H, Nakatsuka A, Takeda K, Sugimura Y. Percutaneous radiofrequency ablation with transarterial embolization is useful for treatment of stage 1 renal cell carcinoma with surgical risk: Results at 2-year mean follow up. Int J Urol. 2007;14:585–590discussion 590
  3. Calderon AJ, Fowlkes JB, Bull JL. Bubble splitting in bifurcating tubes: A model study of cardiovascular gas emboli transport. J Appl Physiol. 2005;99:479–487
  4. Christiansen JP, Lindner JR. Molecular and cellular imaging with targeted contrast ultrasound. Proc IEEE. 2005;809–818
  5. Clark LC, Hoffmann RE, Davis SL. Response of the rabbit lung as a criterion of safety for fluorocarbon breathing and blood substitutes. Biomater Artif Cells Immobilization Biotechnol. 1992;20:1085–1099
  6. Fabiilli ML, Haworth KJ, Fakhri NH, Kripfgans OD, Carson PL, Fowlkes JB. The role of inertial cavitation in acoustic droplet vaporization. IEEE Trans Ultrason Ferroelectr Freq Control. 2009;56:1006–1017
  7. Fang JY, Hung CF, Liao MH, Chien CC. A study of the formulation design of acoustically active lipospheres as carriers for drug delivery. Eur J Pharm Biopharm. 2007;67:67–75
  8. Flaim SF. Pharmacokinetics and side effects of perfluorocarbon-based blood substitutes. Artif Cells Blood Substit Immobil Biotechnol. 1994;22:1043–1054
  9. Flaim SF, Hazard DR, Hogan J, Peters RM. Characterization and mechanism of side-effects of Oxygent HT (highly concentrated fluorocarbon emulsion) in swine. Artif Cells Blood Substit Immobil Biotechnol. 1994;22:1511–1515
  10. Goode JA, Matson MB. Embolisation of cancer: what is the evidence?. Cancer Imaging. 2004;4:133–141
  11. Haworth KJ, Fabiilli ML, Fowlkes JB, Zhang M, Kripfgans OD, Roberts WW, et al. Mean echo power as a measure of flow reduction for bubble occlusion therapy. Proc IEEE Ultrason Symp. 2008;776–779
  12. Haworth KJ, Fowlkes JB, Carson PL, Kripfgans OD. Towards aberration correction of transcranial ultrasound using acoustic droplet vaporization. Ultrasound Med Biol. 2008;34:435–445
  13. Hogg JC. Neutrophil kinetics and lung injury. Physiol Rev. 1987;67:1249–1295
  14. Kalman D, Varenhorst E. The role of arterial embolization in renal cell carcinoma. Scand J Urol Nephrol. 1999;33:162–170
  15. Kawabata K-I, Asami R, Azuma T, Yoshikawa H, Umemura S-I. Cavitation assisted HIFU with phase-change nano droplet. IEEE Ultrason Symp. 2008;1:780–783
  16. Klibanov AL. Targeted delivery of gas-filled microspheres, contrast agents for ultrasound imaging. Adv Drug Deliv Rev. 1999;37:139–157
  17. Kripfgans OD, Fowlkes JB, Miller DL, Eldevik OP, Carson PL. Acoustic droplet vaporization for therapeutic and diagnostic applications. Ultrasound Med Biol. 2000;26:1177–1189
  18. Kripfgans OD, Fowlkes JB, Woydt M, Eldevik OP, Carson PL. In vivo droplet vaporization for occlusion therapy and phase aberration correction. IEEE Trans Ultrason Ferroelectr Freq Control. 2002;49:726–738
  19. Kripfgans OD, Orifici CM, Carson PL, Ives KA, Eldevik OP, Fowlkes JB. Acoustic droplet vaporization for temporal and spatial control of tissue occlusion: A kidney study. IEEE Trans Ultrason Ferroelectr Freq Control. 2005;52:1101–1110
  20. Leakakos T, Schutt EG, Cavin JC, Smith D, Bradley JD, Strnat CA, et al Pulmonary gas trapping differences among animal species in response to intravenous infusion of perfluorocarbon emulsions. Artif Cells Blood Substit Immobil Biotechnol. 1994;22:1199–1204
  21. Matsuura N, Gorelikov I, Williams R, Wan K, Zhu S, Booth J, et al. Nanoparticle-tagged perfluorocarbon droplets for medical imaging. Material Reseach Society Symposium Proceedings. 2009;1140:1–6
  22. Munro NP, Woodhams S, Nawrocki JD, Fletcher MS, Thomas PJ. The role of transarterial embolization in the treatment of renal cell carcinoma. BJU Int. 2003;92:240–244
  23. Parsons JE, Cain CA, Fowlkes JB. Cost-effective assembly of a basic fiber-optic hydrophone for measurement of high-amplitude therapeutic ultrasound fields. J Acoust Soc Am. 2006;119:1432–1440
  24. Rapoport NY, Kennedy AM, Shea JE, Scaife CL, Nam KH. Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles. J Control Release. 2009;138:268–276
  25. Regan MC, Young LS, Geraghty J, Fitzpatrick JM. Regional renal blood flow in normal and disease states. Urol Res. 1995;23:1–10
  26. Reznik N, Williams R, Matsuura N, Burns PN. Convertible liquid droplets for ultrasound contrast. 15th European Symposium on Ultrasound Contrast Imaging. 2010;1:20–22
  27. Schutt E, Barber P, Fields T, Flaim S, Horodniak J, Keipert P, et al Proposed mechanism of pulmonary gas trapping (PGT) following intravenous perfluorocarbon emulsion administration. Artif Cells Blood Substit Immobil Biotechnol. 1994;22:1205–1214
  28. Schwartz MJ, Smith EB, Trost DW, Vaughan ED. Renal artery embolization: Clinical indications and experience from over 100 cases. BJU Int. 2007;99:881–886
  29. Senior J, Crawley JC, Gregoriadis G. Tissue distribution of liposomes exhibiting long half-lives in the circulation after intravenous injection. Biochim Biophys Acta. 1985;839:1–8
  30. Talu E, Powell RL, Longo ML, Dayton PA. Needle size and injection rate impact microbubble contrast agent population. Ultrasound Med Biol. 2008;34:1182–1185
  31. Watanabe S, Hama Y, Kaji T, Kimura F, Kosuda S. Pre-operative embolization for spontaneous rupture of renal cell carcinoma. Ulster Med J. 2005;74:66–67
  32. Wu F, Wang ZB, Chen WZ, Zou JZ, Bai J, Zhu H, et al. Advanced hepatocellular carcinoma: Treatment with high-intensity focused ultrasound ablation combined with transcatheter arterial embolization. Radiology. 2005;235:659–667
  33. Yamakado K, Anai H, Takaki H, Sakaguchi H, Tanaka T, Kichikawa K, et al. Adrenal metastasis from hepatocellular carcinoma: radiofrequency ablation combined with adrenal arterial chemoembolization in six patients. AJR Am J Roentgenol. 2009;192:W300–W305
  34. Zhang P, Porter T. Ultrasound-induced thermal lesion formation with phase shift emulsion. 8th International Symposium on Therapeutic Ultrasound. 2008;

PII: S0301-5629(10)00311-X

doi: 10.1016/j.ultrasmedbio.2010.06.020

Ultrasound in Medicine and Biology
Volume 36, Issue 10 , Pages 1691-1703 , October 2010

Article Tools

* Image Usage & Resolution