Ultrasound in Medicine and Biology
Volume 36, Issue 9 , Pages 1460-1469 , September 2010

Effects of Focused Ultrasound and Microbubbles on the Vascular Permeability of Nanoparticles Delivered into Mouse Tumors

  • Chung-Yin Lin

      Affiliations

    • Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan
    • Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan
    • ,
  • Yen-Lin Huang

      Affiliations

    • Department of Nephrology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    • ,
  • Jia-Rong Li

      Affiliations

    • Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan
    • ,
  • Fu-Hsiung Chang

      Affiliations

    • Institute of Molecular and Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan
    • ,
  • Win-Li Lin

      Affiliations

    • Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan
    • Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan
    • Corresponding Author InformationAddress correspondence to: Win-Li Lin, Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 1, Sec. 1, Jen-Ai Road, Taipei 100, Taiwan.

Received 21 December 2009 ,Revised 8 May 2010 ,Accepted 8 June 2010.

References 

  1. Aoyagi T, Ishikawa H, Miyaji K, Hayakawa K, Hata M. Cadmium-induced testicular damage in a rat model of subchronic intoxication. Reprod Med Biol. 2002;1:59–63
  2. Bekeredjian R, Kroll RD, Fein E, Tinkow S, Coester C, Winter G, et al. Ultrasound targeted microbubble destruction increases capillary permeability in hepatomas. Ultrasound Med Biol. 2007;33:1592–1598
  3. Bergers G, Benjamin LE. Tumorgenesis and the angiogenic switch. Nat Rev Cancer. 2003;3:401–410
  4. Bothun GD, Rabideau AE, Stoner MA. Hepatoma cell uptake of cationic multi-fluorescent quantum dot liposomes. J Phys Chem B. 2009;113:7725–7728
  5. Carion O, Mahler B, Pons T, Dubertret B. Synthesis, encapsulation, purification and coupling of single quantum dots in phospholipid micelles for their use in cellular and in vivo imaging. Nat Protocols. 2007;2:2383–2390
  6. Chang CF, Chen CY, Chang FH, Tai SP, Chen CY, Yu CH, et al. Cell tracking and detection of molecular expression in live cells using lipid-enclosed CdSe quantum dots as contrast agents for epi-third harmonic generation microscopy. Opt Express. 2008;16:9534–9548
  7. Crowder KC, Hughes MS, Marsh JN, Barbieri AM, Fuhrhop RW, Lanza GM, et al. Sonic activation of molecularly-targeted nanoparticles accelerates transmembrane lipid delivery to cancer cells through contact-medicated mechanisms: implications for enhanced local drug delivery. Ultrasound Med Biol. 2005;31:1693–1700
  8. Diederich CJ, Hynynen K. Ultrasound technology for hyperthermia. Ultrasound Med Biol. 1999;25:871–887
  9. Frenkel V. Ultrasound mediated delivery of drugs and genes to solid tumors. Adv Drug Deliver Rev. 2008;60:1193–1208
  10. Gerstner ER, Sorensen AG, Jain RK, Batchelor TT. Advances in neuroimaging techniques for the evaluation of tumor growth, vascular permeability, and angiogenesis in gliomas. Curr Opin Neurol. 2008;21:728–735
  11. Hancock HA, Smith LH, Cuesta J, Durrani AK, Angstadt M, Palmeri ML, et al. Investigations into pulsed high-intensity focused ultrasound-enhanced delivery: preliminary evidence for a novel mechanism. Ultrasound Med Biol. 2009;35:1722–1736
  12. Hernot S, Klibanov AL. Microbubbles in ultrasound-triggered drug and gene delivery. Adv Drug Deliv Rev. 2008;60:1153–1166
  13. Husseini GA, Pitt WG. Micelles and nanoparticles for ultrasonic drug and gene delivery. Adv Drug Deliv Rev. 2008;60:1137–1152
  14. Hynynen K. Macromolecular delivery across the blood-brain barrier. Methods Mol Biol. 2009;480:175–185
  15. Hynynen K, McDannold N, Vykhodtseva N, Jolesz FA. Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits. Radiology. 2001;220:640–646
  16. Kinoshita M, McDannold N, Jolesz FA, Hynynen K. Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. Proc Natl Acad Sci. 2006;103:11719–11723
  17. Liu Y, Miyoshi H, Nakamura M. Nanomedicine for drug delivery and imaging: a promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles. Int J Cancer. 2007;120:2527–2537
  18. Lukyanov AN, Gao Z, Mazzola L, Torchilin VP. Polyethylene glycol-diacyllipid micelles demonstrate increased accumulation in subcutaneous tumors in mice. Pharm Res. 2002;19:1424–1429
  19. McDannold N, Vykhodtseva N, Hynynen K. Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption. Ultrasound Med Biol. 2008;34:930–938
  20. Morel D, Schwieger I, Hohn L, Terrettaz J, Llull JB, Cornioley YA, et al. Human pharmacokinetics and safety evaluation of SonoVue™, a new contrast agent for ultrasound imaging. Inves Radiol. 2001;35:80–90
  21. Netti PA, Baxter LT, Boucher Y, Skalak R, Jain RK. Time-dependent behavior of interstitial fluid pressure in solid tumors: Implications for drug delivery. Cancer Res. 1995;55:5451–5458
  22. Ng KY, Liu Y. Therapeutic ultrasound: its application in drug delivery. Med Res Rev. 2002;22:204–223
  23. Rapoport NY, Kennedy AM, Shea JE, Scaife CL, Nam KH. Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles. J Control Release. 2009;138:268–276
  24. Salnikov AV, Inversen VV, Koisti M, Sundberg C, Johansson L, Stuhr LB, et al. Lowering of tumor interstitial fluid pressure specifically augments efficacy of chemotherapy. FASEB J. 2003;17:1756–1758
  25. Schlicher RK, Radhakrishna H, Tolentino TP, Apkarian RP, Zarnitsyn V, Prausnitz MR. Mechanism of intracellular delivery by acoustic cavitation. Ultrasound Med Biol. 2006;32:915–924
  26. Tang XL, Peng XH, Dou W, Mao J, Zheng JR, Qin WW, et al. Design of a semi rigid molecule as a selective fluorescent chemosensor for recognition of Cd(II). Org Lett. 2008;10:3653–3656
  27. Treat LH, McDannold N, Vykhodtseva N, Zhang Y, Tam K, Hynynen K. Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound. Int J Cancer. 2007;121:901–907
  28. Yang FY, Fu WM, Chen WS, Yeh WL, Lin WL. Quantitative evaluation of the use of microbubbles with transcranial focused ultrasound on blood-brain-barrier disruption. Ultrason Sonochem. 2008;15:636–643

PII: S0301-5629(10)00281-4

doi: 10.1016/j.ultrasmedbio.2010.06.003

Ultrasound in Medicine and Biology
Volume 36, Issue 9 , Pages 1460-1469 , September 2010

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