Ultrasound in Medicine and Biology
Volume 36, Issue 10 , Pages 1756-1761 , October 2010

Evaluation of Coronary Flow Velocity Reserve in Homozygous Familial Hypercholesterolemia by Transthoracic Doppler Echocardiography and Dual-Source Computed Tomography

  • Ya Yang

      Affiliations

    • Department of Ultrasound, Beijing Anzhen Hospital, Capital Medical University, Beijing, P. R. China
    • ,
  • Xiaoshan Zhang

      Affiliations

    • Department of Ultrasound, Beijing Anzhen Hospital, Capital Medical University, Beijing, P. R. China
    • ,
  • Rongjuan Li

      Affiliations

    • Department of Ultrasound, Beijing Anzhen Hospital, Capital Medical University, Beijing, P. R. China
    • ,
  • Hongyan Ren

      Affiliations

    • Department of Ultrasound, Beijing Anzhen Hospital, Capital Medical University, Beijing, P. R. China
    • ,
  • Zheng Wang

      Affiliations

    • Department of Ultrasound, Beijing Anzhen Hospital, Capital Medical University, Beijing, P. R. China
    • ,
  • Zhian Li

      Affiliations

    • Department of Ultrasound, Beijing Anzhen Hospital, Capital Medical University, Beijing, P. R. China
    • Corresponding Author InformationAddress correspondence to: Zhian Li, M.D., Department of Ultrasound Beijing, Anzhen Hospital, Capital Medical University, Beijing, 100029 P. R. China.
    • ,
  • Jie Lin

      Affiliations

    • Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, P. R.China
    • ,
  • Luya Wang

      Affiliations

    • Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, P. R.China
    • ,
  • Wei Yu

      Affiliations

    • Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, P. R. China
    • ,
  • Zhaoqi Zhang

      Affiliations

    • Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, P. R. China

Received 15 October 2009 ,Revised 8 May 2010 ,Accepted 14 May 2010.

References 

  1. Awan Z, Alrasadi K, Francis GA, Hegele RA, McPherson R, Frohlich J, et al. Vascular calcifications in homozygote familial hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2008;28:777–785
  2. Bartel T, Müller S, Baumgart D, Mathew B, Haude M, Erbel R. Improved high frequency transthoracic flow velocity measurement in the left anterior descending coronary artery after intravenous peripheral injection of Levovist. J Am Soc Echocardiogr. 1999;12:252–256
  3. Beppu S, Minura Y, Sakakibara H, Nagata S, Park YD, Nambu S, et al. Supravalvular aortic stenosis and coronary ostial stenosis in familial hypercholesterolemia: Two-dimensional echocardiographic assessment. Circulation. 1983;67:878–884
  4. Civeira F, Castillo S, Alonso R, Merino Ibarra E, Cenarro A, Artied M, et al. Tendon xanthomas in familial hypercholesterolemia are associated with cardiovascular risk independently of the low-density lipoprotein receptor gene mutation. Arterioscler Thromb Vasc Biol. 2005;25:1960–1965
  5. Erbel R, Ge J, Bockisch A, Kearney P, GÖrge G, Haude M, et al. Value of intracoronary ultrasound and Doppler in the differentiation of angiographically normal coronary arteries: A prospective study in patients with angina pectoris. Eur Heart J. 1996;17:880–889
  6. Faccenda F, Rubba P, Gnasso A, Pauciullo P, Postiglione A, Cortese C, et al. Noninvasive ultrasound evaluation of pressure gradients in aortic root of homozygotes for familial hypercholesterolemia. Arteriosclerosis. 1990;10:710–713
  7. Kaufmann PA, Gnecchi-Ruscone T, Schäfers KP, Lüscher TF, Camici PG. Low density lipoprotein cholesterol and coronary microvascular dysfunction in hypercholesterolemia. J Am Coll Cardiol. 2000;36:103–109
  8. Kraft HG, Lingenhel A, Raal FJ, Hohenegger M, Utermann G. Lipoprotein(a) in homozygous familial hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2000;20:522–528
  9. Marais AD. Familial hypercholesterolemia. Clin Biochem Rev. 2004;25:49–68
  10. Murata E, Hozumi T, Matsumura Y, Fujimoto K, Sugioka K, Takemoto Y, et al. Coronary flow velocity reserve measurement in three major coronary arteries using transthoracic Doppler echocardiography. Echocardiography. 2006;23:279–286
  11. Santos RD, Miname MH, Martinez LC, Rochitte CE, Chacra AM, Nakandakare ER, et al. Noninvasive detection of aortic and coronary atherosclerosis in homozygous familial hypercholesterolemia by 64-slice multidetector row computed tomography angiography. Atherosclerosis. 2008;197:910–915
  12. Summers RM, Andrasko-Bourgeois J, Feuerstein IM, Hill SC, Jones EC, Busse MK, et al. Evaluation of the aortic root by MRI: Insights from patients with homozygous familial hypercholesterolemia. Circulation. 1998;98:509–518
  13. Wiegman A, Rodenburg J, de Jongh S, Defesche J, Bakker H, Kastelein JP, et al. Family history and cardiovascular risk in familial hypercholesterolemia: Data in more than 1000 children. Circulation. 2003;107:1473–1478
  14. Yokoyama I, Murakami T, Ohtake T, Momomura S, Nishikawa J, Sasaki Y, et al. Reduced coronary flow reserve in familial hypercholesterolemia. J Nucl Med. 1996;37:1937–1942

PII: S0301-5629(10)00243-7

doi: 10.1016/j.ultrasmedbio.2010.05.013

Ultrasound in Medicine and Biology
Volume 36, Issue 10 , Pages 1756-1761 , October 2010

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