Ultrasound in Medicine and Biology
Volume 36, Issue 8 , Pages 1298-1305 , August 2010

The Effect of Variable Waveform Low-Intensity Pulsed Ultrasound in a Fourth Metacarpal Osteotomy Gap Model in Horses

  • S.R. McClure

      Affiliations

    • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames
    • Corresponding Author InformationAddress correspondence to: Dr. S. R. McClure, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50010-1250.
    • ,
  • K. Miles

      Affiliations

    • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames
    • ,
  • D. VanSickle

      Affiliations

    • Department of Basic Medical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN
    • ,
  • T. South

      Affiliations

    • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames

Received 12 November 2009 ,Revised 2 April 2010 ,Accepted 5 May 2010.

References 

  1. Borden M. The development of bone graft materials using various formulations of demineralized bone matrix. In:  Laurencin CT editors. Bone graft substitutes. West Conshohocken (PA): ASTM International; 2003;p. 96–112
  2. Busse JW, Bhandar M, Kulkarni AV, Tunks E. The effect of low-intensity pulsed ultrasound therapy on time to fracture healing: a meta-analysis. Can Med Assoc J. 2002;166:437–441
  3. Chang WH-S, Sun J-S, Chyang S-P, Lin JC. Study of thermal effects of ultrasound stimulation on fracture healing. Bioelectromagnetics. 2002;23:256–263
  4. Cheung EV, Katti DS, Rosier RN, Laurencin CT. Review of state of the art: Growth factor-based systems for use as bone graft substitutes. In:  Laurencin CT editors. Bone graft substitutes. West Conshohocken (PA): ASTM International; 2003;p. 174–193
  5. Claes L, Augat P, Suger G, Wilke H-J. Influence of size and stability of the osteotomy gap on the success of fracture healing. J Orthop Res. 1997;15:577–584
  6. Claes L, Willie B. The enhancement of bone regeneration by ultrasound. Progr Biophys Mol Biol. 2007;93:384–398
  7. Dinno MA, Dyson M, Young SR, Mortimer AJ, Hart J, Crum LA. The significance of membrane changes in the safe and effective use of therapeutic and diagnostic ultrasound. Phys Med Biol. 1989;34:1543–1552
  8. Dyson M. Non-thermal cellular effects of ultrasound. Br J Cancer Suppl. 1982;45:165–171
  9. Ducharme NG, Nixon AJ. Delayed union, nonunion, and malunion. In:  Nixon AJ editors. Equine fracture repair. Philadelphia: W.B. Saunders Company; 1996;354–358
  10. Dyson M, Brookes M. Stimulation of bone repair by ultrasound. Ultrasound Med Biol. 1983;2:61–66
  11. Einhorn TA. Enhancement of fracture-healing. J Bone Joint Surg. 1995;77:940–956
  12. Fossum TW, Hedlund CS, Johnson AL, Schulz KS, Seim HB, Willard MD, et al. Small animal surgery. St. Louis: Mosby; 2007;
  13. Fritton SP, McLeod KJ, Rubin CT. Quantifying the strain history of bone: Spatial uniformity and self-similarity of low-magnitude strains. J Biomech. 2000;33:317–325
  14. Goodship AE, Lawes T, Rubin CT. Low-magnitude high-frequency mechanical signals accelerate and augment endochondral bone repair: Preliminary evidence of efficacy. J Orthop Res. 2009;27:922–930
  15. Heckman JD, Ryaby JP, McCabe J, Frey JJ, KIlcoyne RF. Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound. J Bone Joint Surg Am. 1994;76:26–34
  16. Hofer S, Leiopold SS, Jacobs JJ. Clinical perspectives on the use of bone graft based allografts. In:  Laurencin CT editors. Bone graft substitutes. West Conshohocken (PA): ASTM International; 2003;68–95
  17. Huang RP, Rubin CT, McLeod KJ. Changes in postural muscle dynamics as a function of age. J Gerontol A Biol Sci Med Sci. 1999;54:B352–B357
  18. Jenson PW, Gaughan EM, Lillich JD, Bryant JE. Segmental ostecotmy of the second and fourth metacarpal and metatarsal bones in horses: 17 cases 1993–2002. 2004;224:271–274.
  19. Johannes EJ, Sukul DMKS, Mathura E. High-energy shock waves for the treatment of nonunions: An experiment in dogs. J Surg Res. 1994;57:246–252
  20. Klug W, Franke WG, Knoch HG. Scintigraphic control of bone-fracture healing under ultrasonic stimulation: An animal experimental study. Eur J Nucl Med. 1986;11:494–497
  21. Kristiansen TK, Ryaby JP, McCabe J, Frey JJ, Roe LR. Accelerated healing of distal radial fractures with the use of specific, low-intensity ultrasound. A multicenter, prospective, randomized, double-blind, placebo-controlled study. J Bone Joint Surg Am. 1997;79:961–973
  22. Markel MD. Bone grafts and bone substitutes. In:  Nixon AJ editors. Equine fracture repair. Philadelphia: W.B. Saunders Company; 1996;87–91
  23. Millis DL, Jackson AM. Delayed unions, nonunions, and malunions. In:  Slatter D editors. Textbook of small animal surgery. Philadelphia: Elsevier; 2003;1849–1861
  24. Moretti B, Notarnicola A, Garofalo R, Moretti L, Patella S, Marlinghhaus E, et al. Shock waves in the treatment of stress fractures. Ultrasound Med Biol. 2009;35:1042–1049
  25. Ostrum RF, Chao EYPS, Bassett CAL, Brighton CT, Einhorn TA, Lucas TS, et al. Rosemont (IL): Academy of Orthopaedic Surgeons, Port City Press; 1994;277–323
  26. Perrier M, Lu Y, Nemke B, Kobayshi H, Peterson A, Markel M. Acceleration of second and fourth metatarsal fracture healing with recombinant human bone morphogenic protein-2/calcium phosphate cement in horses. Vet Surg. 2008;37:648–655
  27. Pilla AA, Mont MA, Nasser PR, Khan SA, Figueired M, Kaufman JJ, et al. Non-invasive low-intensity pulsed ultrasound accelerates bone healing in the rabbit. J Orthop Trauma. 1990;4:246–253
  28. Rawool NM, Goldberg BB, Forsberg F, Winder AA, Hume E. Power Doppler assessment of vascular changes during fracture treatment with low-intensity ultrasound. J Ultrasound Med. 2003;22:145–153
  29. Rubin C, Bolander M, Ryaby JP, Hadjiargyrou M. The use of low-intensity ultrasound to accelerate the healing of fractures. J Bone Joint Surg Am. 2001;83-A:259–270
  30. Sathishkumar S, Meka A, Dawson D, House N, Schaden W, Novak MJ, et al. Extracorporeal shock wave therapy induces alveolar bone regeneration. J Dent Res. 2008;87:687–691
  31. Schaden W, Fischer A, Sailler A. Extracorporeal shock wave therapy of nonunion or delayed osseous union. Clin Orthop Rel Res. 2001;387:268–269
  32. Southwood LL, Kawcak CE, McIlwraith CW, Frisbie DD. Evaluation of an equine metacarpal IV fracture defect model [abstrac]. Vet Surg. 2006;35:E25
  33. Taki M, Iwata O, Shiono M, Kimura M, Takagishi K. Extracorporeal shock wave therapy for resistant stress fracture in athletes, a report of 5 cases. Am J Sports Med. 2007;35:1188–1192
  34. Tsai CL, Chang WH, Liu TK, Song GM. Ultrasound can affect bone healing both locally and systemically. Clin J Physiol. 1991;34:213–222
  35. Tsai CL, Chang WH, Liu TK. Preliminary studies of duration and intensity of ultrasonic treatments on fracture repair. Chin J Physiol. 1992;35:21–26
  36. Wang CJ, Wang FS, Huang CC, Yang KD, Weng LH, Huang HY. Treatment for osteonecrosis of the femoral head: comparison of extracorporeal shock waves with core decompression and bone-grafting. J Bone Joint Surg Am. 2005;87:2380–2387
  37. Waselau M, Samii VF, Weisbrode SE, Litsky AS, Bertone AL. Effects of magnesium adhesive cement on bone stability and healing following a metatarsal osteotomy in horses. Am J Vet Res. 2007;68:370–378
  38. Welgus HG, Jeffrey JJ, Eisen AZ. Human skin fibroblast collagenase. Assessment of activation energy and deuterium isotope effect with collageous substrates. J Biol Chem. 1981;256:9516–9521

PII: S0301-5629(10)00224-3

doi: 10.1016/j.ultrasmedbio.2010.05.005

Ultrasound in Medicine and Biology
Volume 36, Issue 8 , Pages 1298-1305 , August 2010

Article Tools

* Image Usage & Resolution