Changes in Hemocoagulation in Acute Stroke Patients After One-Hour Sono-Thrombolysis Using a Diagnostic Probe

Školoudík, David; Fadrná, Táňa; Roubec, Martin; Bar, Michal; Zapletal, Ondřej; Blatný, Jiří; Langová, Kateřina; Bardoň, Petr; Šaňák, Daniel; Kaňovský, Petr; Herzig, Roman

doi:10.1016/j.ultrasmedbio.2010.04.010

« Previous Next »Ultrasound in Medicine and Biology
Volume 36, Issue 7 , Pages 1052-1059, July 2010

Changes in Hemocoagulation in Acute Stroke Patients After One-Hour Sono-Thrombolysis Using a Diagnostic Probe

David Školoudík
- Department of Neurology, University Hospital, Ostrava, Czech Republic
- Stroke Center, Department of Neurology, Faculty of Medicine and Dentistry, Palacký University and University Hospital, Olomouc, Czech Republic
- Address correspondence to: Assoc. Prof. David Školoudík, MD, PhD, Stroke Center, Department of Neurology, Faculty of Medicine and Dentistry, Palacký University and University Hospital, I. P. Pavlova 6, CZ-77520 Olomouc, Czech Republic.
Táňa Fadrná
- Department of Neurology, University Hospital, Ostrava, Czech Republic
Martin Roubec
- Department of Neurology, University Hospital, Ostrava, Czech Republic
Michal Bar
- Department of Neurology, University Hospital, Ostrava, Czech Republic
Ondřej Zapletal
- Department of Clinical Hematology, University Children's Hospital Brno, Czech Republic
Jiří Blatný
- Department of Clinical Hematology, University Children's Hospital Brno, Czech Republic
Kateřina Langová
- Department of Biometry, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic
Petr Bardoň
- Department of Neurology, Hospital Třinec-Sosna, Třinec, Czech Republic
Daniel Šaňák
- Stroke Center, Department of Neurology, Faculty of Medicine and Dentistry, Palacký University and University Hospital, Olomouc, Czech Republic
Petr Kaňovský
- Stroke Center, Department of Neurology, Faculty of Medicine and Dentistry, Palacký University and University Hospital, Olomouc, Czech Republic
Roman Herzig
- Stroke Center, Department of Neurology, Faculty of Medicine and Dentistry, Palacký University and University Hospital, Olomouc, Czech Republic

Received 1 December 2009; received in revised form 26 March 2010; accepted 16 April 2010.

Abstract

The aim was to monitor the changes in hemocoagulation parameters in acute ischemic stroke (AIS) patients after sono-thrombolysis of the occluded middle cerebral artery using a duplex transcranial probe with 2.0-MHz frequency in Doppler mode. Sixteen AIS patients indicated for intravenous thrombolysis (IVT) (8 males; mean age 68.3 ± 7.1 y) and 16 AIS patients contraindicated for IVT (11 males; mean age 67.9 ± 7.9 y) were randomized for sono-thrombolysis (8 + 8 patients) or standard treatment (control group) (8 + 8 patients). The significant decrease of plasminogen activator inhibitor-1, plasminogen and α-2-antiplasmin activity by a mean of 60, 32 and 24%, respectively, and the increase of tissue plasminogen activator by a mean of 56% was found after sono-thrombolysis when compared with control group (p < 0.0125); these changes were more evident in patients treated with a combination of sono-thrombolysis and IVT (79, 38, 50 and 82%, respectively) than in patients treated by sono-thrombolysis alone (34, 13, 17 and 30%, respectively). (E-mail: skoloudik@hotmail.com)

Key Words: Ultrasound monitoring, Sono-thrombolysis, Stroke, Hemocoagulation, Fibrinolytic system, Transcranial Doppler