Ultrasound in Medicine and Biology
Volume 36, Issue 3 , Pages 419-429 , March 2010

Cavitation Properties of Block Copolymer Stabilized Phase-Shift Nanoemulsions Used as Drug Carriers

  • Natalya Rapoport

      Affiliations

    • Department of Bioengineering, University of Utah, Salt Lake City, UT, USA
    • Corresponding Author InformationAddress correspondence to: Natalya Rapoport, Department of Bioengineering, University of Utah, 72 South Central Campus Drive, Room 2646, Salt Lake City, UT 84112, USA.
    • ,
  • Douglas A. Christensen

      Affiliations

    • Department of Bioengineering, University of Utah, Salt Lake City, UT, USA
    • Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT, USA
    • ,
  • Anne M. Kennedy

      Affiliations

    • Department of Clinical Radiology, School of Medicine, University of Utah, Salt Lake City, UT, USA
    • ,
  • Kweon-Ho Nam

      Affiliations

    • Department of Bioengineering, University of Utah, Salt Lake City, UT, USA

Received 22 December 2008 ,Revised 17 November 2009 ,Accepted 20 November 2009.

References 

  1. Barber EJ, Cady GH. Vapor pressures of perfluoropentanes. J Phys Chem. 1956;60:504–505
  2. Bekeredjian R, Chen S, Frenkel PA, Grayburn PA, Shohet RV. Ultrasound-targeted microbubble destruction can repeatedly direct highly specific plasmid expression to the heart. Circulation. 2003;108:1022–1026
  3. Campbell RB. Tumor physiology and delivery of nanopharmaceuticals. Anticancer Agents Med Chem. 2006;6:503–512
  4. Chang PP, Chen WS, Mourad PD, Poliachik SL, Crum LA. Thresholds for inertial cavitation in albunex suspensions under pulsed ultrasound conditions. IEEE Trans Ultrason Ferroelectr Freq Control. 2001;48:161–170
  5. Chappell JC, Klibanov AL, Price RJ. Ultrasound-microbubble-induced neovascularization in mouse skeletal muscle. Ultrasound Med Biol. 2005;31:1411–1422
  6. Chen WS, Brayman AA, Matula TJ, Crum LA. Inertial cavitation dose and hemolysis produced in vitro with or without Optison. Ultrasound Med Biol. 2003;29:725–737
  7. Church CC, Carstensen EL. Stable' inertial cavitation. Ultrasound Med Biol. 2001;27:1435–1437
  8. Clasohm LY, Vakarelski IU, Dagastine RR, Chan DY, Stevens GW, Grieser F. Anomalous pH dependent stability behavior of surfactant-free nonpolar oil drops in aqueous electrolyte solutions. Langmuir. 2007;23:9335–9340
  9. Datta S, Coussios CC, Ammi AY, Mast TD, de Courten-Myers GM, Holland CK. Ultrasound-enhanced thrombolysis using Definity as a cavitation nucleation agent. Ultrasound Med Biol. 2008;34:1421–1433
  10. Dayton PA, Zhao S, Bloch SH, Schumann P, Penrose K, Matsunaga TO, et al. Application of ultrasound to selectively localize nanodroplets for targeted imaging and therapy. Mol Imaging. 2006;5:160–174
  11. Ferrara K, Pollard R, Borden M. Ultrasound microbubble contrast agents: Fundamentals and application to gene and drug delivery. Annu Rev Biomed Eng. 2007;9:415–447
  12. Ferrara K, Borden M, Zhang H. Lipid-shelled vehicles: Engineering for ultrasound molecular imaging and drug delivery. Acc Chem Re. 2009;PMID: 19552457
  13. Gao Z, Kennedy AM, Christensen DA, Rapoport NY. Drug-loaded nano/microbubbles for combining ultrasonography and targeted chemotherapy. Ultrasonics. 2008;48:260–270
  14. Giesecke T, Hynynen K. Ultrasound-mediated cavitation thresholds of liquid perfluorocarbon droplets in vitro. Ultrasound Med Biol. 2003;29:1359–1365
  15. Greenleaf WJ, Bolander ME, Sarkar G, Goldring MB, Greenleaf JF. Artificial cavitation nuclei significantly enhance acoustically induced cell transfection. Ultrasound Med Biol. 1998;24:587–595
  16. Hernot S, Klibanov AL. Microbubbles in ultrasound-triggered drug and gene delivery. Adv Drug Deliv Rev. 2008;60:1153–1166
  17. Hobbs SK, Monsky WL, Yuan F, Roberts WG, Griffith L, Torchilin VP, et al. Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment. Proc Natl Acad Sci U S A. 1998;95:4607–4612
  18. Holland CK, Apfel RE. Thresholds for transient cavitation produced by pulsed ultrasound in a controlled nuclei environment. J Acoust Soc Am. 1990;88:2059–2069
  19. Hynynen K. Ultrasound for drug and gene delivery to the brain. Adv Drug Deliv Rev. 2008;60:1209–1217
  20. Iyer AK, Khaled G, Fang J, Maeda H. Exploiting the enhanced permeability and retention effect for tumor targeting. Drug Discov Today. 2006;11:812–818
  21. Kinoshita M, McDannold N, Jolesz FA, Hynynen K. Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. Proc Natl Acad Sci U S A. 2006;103:11719–11723
  22. Kripfgans OD, Fabiilli ML, Carson PL, Fowlkes JB. On the acoustic vaporization of micrometer-sized droplets. J Acoust Soc Am. 2004;116:272–281
  23. Kripfgans OD, Fowlkes JB, Miller DL, Eldevik OP, Carson PL. Acoustic droplet vaporization for therapeutic and diagnostic applications. Ultrasound Med Biol. 2000;26:1177–1189
  24. Lo AH, Kripfgans OD, Carson PL, Rothman ED, Fowlkes JB. Acoustic droplet vaporization threshold: effects of pulse duration and contrast agent. IEEE Trans Ultrason Ferroelectr Freq Control. 2007;54:933–946
  25. Mehier-Humbert S, Yan F, Frinking P, Schneider M, Guy RH, Bettinger T. Ultrasound-mediated gene delivery: influence of contrast agent on transfection. Bioconjug Chem. 2007;18:652–662
  26. Miller DL, Averkiou MA, Brayman AA, Everbach EC, Holland CK, Wible JH, et al. Bioeffects considerations for diagnostic ultrasound contrast agents. J Ultrasound Med. 2008;27:611–632quiz 33–36
  27. Miller DL, Gies RA. The interaction of ultrasonic heating and cavitation in vascular bioeffects on mouse intestine. Ultrasound Med Biol. 1998;24:123–128
  28. Rapoport N, Marin A, Christensen DA. Ultrasound-activated micellar drug delivery. Drug Delivery Syst Sci. 2002;2:37–46
  29. Rapoport N. Combined cancer therapy by micellar-encapsulated drug and ultrasound. In:  Amiji M editors. Nanotechnology for cancer therapy. Boca Raton, FL: CRC Press; 2006;p. 417–437
  30. Rapoport N. Tumor targeting by polymeric assemblies and ultrasound activation. In:  Arshadi R,  Kono K editor. MML. London, UK: Kentus Books; 2006;p. 305–362
  31. Rapoport N. Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery. Prog Polym Sci. 2007;32:962–990
  32. Rapoport N, Gao Z, Kennedy A. Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy. J Natl Cancer Inst. 2007;99:1095–1106
  33. Rapoport N, Kennedy AM, Shea JE, Scaife CL, Nam KH. Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles. J Control Release. 2009;138:268–276
  34. Rapoport NY, Efros AL, Christensen DA, Kennedy AM, Nam KH. Microbubble generation in phase-shift nanoemulsions used as anticancer drug carriers. Bub Sci Eng Tech. 2009;1:31–39
  35. Schroeder A, Avnir Y, Weisman S, Najajreh Y, Gabizon A, Talmon Y, et al. Controlling liposomal drug release with low frequency ultrasound: Mechanism and feasibility. Langmuir. 2007;23:4019–4025
  36. Skyba DM, Price RJ, Linka AZ, Skalak TC, Kaul S. Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue. Circulation. 1998;98:290–293
  37. Stieger SM, Caskey CF, Adamson RH, Qin S, Curry FR, Wisner ER, et al. Enhancement of vascular permeability with low-frequency contrast-enhanced ultrasound in the chorioallantoic membrane model. Radiology. 2007;243:112–121
  38. Suzuki R, Takizawa T, Negishi Y, Hagisawa K, Tanaka K, Sawamura K, et al. Gene delivery by combination of novel liposomal bubbles with perfluoropropane and ultrasound. J Control Release. 2007;117:130–136
  39. ter Haar GR. Ultrasonic biophysics. Chichester, UK: Wiley; 2004;
  40. Unger EC, Porter T, Culp W, Labell R, Matsunaga T, Zutshi R. Therapeutic applications of lipid-coated microbubbles. Adv Drug Deliv Rev. 2004;56:1291–1314
  41. Wheatley MA, Forsberg F, Oum K, Ro R, El-Sherif D. Comparison of in vitro and in vivo acoustic response of a novel 50:50 PLGA contrast agent. Ultrasonics. 2006;44:360–367

PII: S0301-5629(09)01657-3

doi: 10.1016/j.ultrasmedbio.2009.11.009

Ultrasound in Medicine and Biology
Volume 36, Issue 3 , Pages 419-429 , March 2010

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