Ultrasound in Medicine and Biology
Volume 36, Issue 3 , Pages 419-429, March 2010

Cavitation Properties of Block Copolymer Stabilized Phase-Shift Nanoemulsions Used as Drug Carriers

  • Natalya Rapoport

      Affiliations

    • Department of Bioengineering, University of Utah, Salt Lake City, UT, USA
    • Corresponding Author InformationAddress correspondence to: Natalya Rapoport, Department of Bioengineering, University of Utah, 72 South Central Campus Drive, Room 2646, Salt Lake City, UT 84112, USA.
    • ,
  • Douglas A. Christensen

      Affiliations

    • Department of Bioengineering, University of Utah, Salt Lake City, UT, USA
    • Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT, USA
    • ,
  • Anne M. Kennedy

      Affiliations

    • Department of Clinical Radiology, School of Medicine, University of Utah, Salt Lake City, UT, USA
    • ,
  • Kweon-Ho Nam

      Affiliations

    • Department of Bioengineering, University of Utah, Salt Lake City, UT, USA

Received 22 December 2008; received in revised form 17 November 2009; accepted 20 November 2009. published online 04 February 2010.

Abstract 

Cavitation properties of block copolymer stabilized perfluoropentane nanoemulsions have been investigated. The nanoemulsions were stabilized by two biodegradable amphiphilic block copolymers differing in the structure of the hydrophobic block, poly(ethylene oxide)-co-poly(L-lactide) (PEG-PLLA) and poly(ethylene oxide)-co-polycaprolactone (PEG-PCL). Cavitation parameters were measured in liquid emulsions and gels as a function of ultrasound pressure for unfocused or focused 1-MHz ultrasound. Acoustic droplet vaporization preceded generation of acoustic cavitation in liquid matrices and gels. Both stable and inertial cavitation was observed for focused ultrasound while only stable cavitation was observed for unfocused ultrasound. (E-mail: Natasha.rapoport@utah.edu)

Key Words: Nanoemulsions, Microbubbles, Acoustic droplet vaporization, Cavitation

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PII: S0301-5629(09)01657-3

doi:10.1016/j.ultrasmedbio.2009.11.009

Ultrasound in Medicine and Biology
Volume 36, Issue 3 , Pages 419-429, March 2010

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