Ultrasound in Medicine and Biology
Volume 35, Issue 10 , Pages 1587-1595 , October 2009

Real-Time Contrast-Enhanced Ultrasound for the Assessment of Perfusion Dynamics in Skeletal Muscle

  • Martin Krix

      Affiliations

    • German Cancer Research Center, Research Program Imaging and Radiooncology, Department of Radiology, Heidelberg, Germany
    • Bracco Imaging Germany, Konstanz, Germany
    • Corresponding Author InformationAddress correspondence to: Martin Krix, P.D., Dr. med., Dipl. Phys., German Cancer Research Center Heidelberg, INF 280, D-69120 Heidelberg, Germany.
    • ,
  • Holger Krakowski-Roosen

      Affiliations

    • German Cancer Research Center, Department of Immunochemistry, Heidelberg, Germany
    • ,
  • Hans-Ulrich Kauczor

      Affiliations

    • University Hospital of Heidelberg, Department of Diagnostic and Interventional Radiology, Heidelberg, Germany
    • ,
  • Stefan Delorme

      Affiliations

    • German Cancer Research Center, Research Program Imaging and Radiooncology, Department of Radiology, Heidelberg, Germany
    • ,
  • Marc-André Weber

      Affiliations

    • German Cancer Research Center, Research Program Imaging and Radiooncology, Department of Radiology, Heidelberg, Germany
    • University Hospital of Heidelberg, Department of Diagnostic and Interventional Radiology, Heidelberg, Germany

Received 21 January 2009 ,Revised 26 March 2009 ,Accepted 4 May 2009.

References 

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  2. Clifford PS, Hellsten Y. Vasodilatory mechanisms in contracting skeletal muscle. J Appl Physiol. 2004;97:393–403
  3. Clifford PS. Skeletal muscle vasodilatation at the onset of exercise. J Physiol. 2007;583(Pt 3):825–833
  4. Coggins M, Lindner J, Rattigan S, Jahn L, Fasy E, Kaul S, et al. Physiologic hyperinsulinemia enhances human skeletal muscle perfusion by capillary recruitment. Diabetes. 2001;50:2682–2690
  5. Duerschmied D, Olson L, Olschewski M, Rossknecht A, Freund G, Bode C, et al. Contrast ultrasound perfusion imaging of lower extremities in peripheral arterial disease: A novel diagnostic method. Eur Heart J. 2006;27:310–315
  6. Duerschmied D, Maletzki P, Freund G, Olschewski M, Seufert J, Bode C, et al. Analysis of muscle microcirculation in advanced diabetes mellitus by contrast enhanced ultrasound. Diabetes Res Clin Pract. 2008;81:88–92
  7. Gorce JM, Arditi M, Schneider M. Influence of bubble size distribution on the echogenicity of ultrasound contrast agents: A study of SonoVue. Invest Radiol. 2000;35:661–671
  8. Joyner MJ, Dietz NM, Shepherd JT. From Belfast to Mayo and beyond: the use and future of plethysmography to study blood flow in human limbs. J Appl Physiol. 2001;91:2431–2441
  9. Krix M, Weber MA, Krakowski-Roosen H, Huttner HB, Delorme S, Kauczor HU, et al. Assessment of skeletal muscle perfusion using contrast-enhanced ultrasonography. J Ultrasound Med. 2005;24:431–441
  10. Lohmaier S, Ghanem A, Veltmann C, Sommer T, Bruce M, Tiemann K. In vitro and in vivo studies on continuous echo-contrast application strategies using SonoVue in a newly developed rotating pump setup. Ultrasound Med Biol. 2004;30:1145–1151
  11. Mulder AH, van Dijk AP, Smits P, Tack CJ. Real-time contrast imaging: A new method to monitor capillary recruitment in human forearm skeletal muscle. Microcirculation. 2008;15:203–213
  12. Murrant CL, Sarelius IH. Coupling of muscle metabolism and muscle blood flow in capillary units during contraction. Acta Physiol Scand. 2000;168:531–541
  13. Slaaf DW, Oude Egbrink MG. Capillaries and flow redistribution play an important role in muscle blood flow reserve capacity. J Mal Vasc. 2002;27:63–67
  14. Weber MA, Krix M, Jappe U, Huttner HB, Hartmann M, Meyding-Lamadé U, et al. Pathologic skeletal muscle perfusion in patients with myositis: detection with quantitative contrast-enhanced US–initial results. Radiology. 2006;238:640–649
  15. Weber MA, Krakowski-Roosen H, Delorme S, Renk H, Krix M, Millies J, et al. Relationship of skeletal muscle perfusion measured by contrast-enhanced ultrasonography to histologic microvascular density. J Ultrasound Med. 2006;25:583–591
  16. Weber MA, Krakowski-Roosen H, Schroder L, Kinscherf R, Krix M, Kopp-Schneider A, et al. Morphology, metabolism, microcirculation, and strength of skeletal muscles in cancer-related cachexia. Acta Oncol. 2008;19:1–9

PII: S0301-5629(09)00218-X

doi: 10.1016/j.ultrasmedbio.2009.05.006

Ultrasound in Medicine and Biology
Volume 35, Issue 10 , Pages 1587-1595 , October 2009

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