Ultrasound in Medicine and Biology
Volume 35, Issue 9 , Pages 1546-1554 , September 2009

Minimally Invasive Ultrasound Method for Intra-Articular Diagnostics of Cartilage Degeneration

  • T. Virén

      Affiliations

    • Department of Physics, University of Kuopio, Kuopio University Hospital, Kuopio, Finland
    • Corresponding Author InformationAddress correspondence to: Tuomas Virén, Department of Physics, University of Kuopio, POB 1627, FI-70211 Kuopio, Finland.
    • ,
  • S. Saarakkala

      Affiliations

    • Department of Physics, University of Kuopio, Kuopio University Hospital, Kuopio, Finland
    • ,
  • E. Kaleva

      Affiliations

    • Department of Physics, University of Kuopio, Kuopio University Hospital, Kuopio, Finland
    • ,
  • H.J. Nieminen

      Affiliations

    • Department of Physics, University of Kuopio, Kuopio University Hospital, Kuopio, Finland
    • ,
  • J.S. Jurvelin

      Affiliations

    • Department of Physics, University of Kuopio, Kuopio University Hospital, Kuopio, Finland
    • ,
  • J. Töyräs

      Affiliations

    • Department of Physics, University of Kuopio, Kuopio University Hospital, Kuopio, Finland
    • Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland

Received 6 October 2008 ,Revised 23 March 2009 ,Accepted 8 April 2009.

References 

  1. Adler RS, Dedrick DK, Laing TJ, Chiang EH, Meyer CR, Bland PH, et al. Quantitative assessment of cartilage surface roughness in osteoarthritis using high frequency ultrasound. Ultrasound Med Biol. 1992;18:51–58
  2. Arden N, Nevitt MC. Osteoarthritis: Epidemiology. Best Pract Res Clin Rheumatol. 2006;20:3–25
  3. Bashir A, Gray ML, Boutin RD, Burstein D. Glycosaminoglycan in articular cartilage: In vivo assessment with delayed Gd(DTPA)(2-)-enhanced MR imaging. Radiology. 1997;205:551–558
  4. Blake GM, Wahner HW, Fogelman I. The evaluation of osteoporosis: Dual energy X-ray absorptiometry and ultrasound in clinical practice. London: Martin Dunitz Ltd.; 1999;
  5. Buckwalter JA, Martin J. Degenerative joint disease. Clin Symp. 1995;47:1–32
  6. Buckwalter JA, Mankin J. Articular cartilage: Part II. Degeneration and osteoarthritis, repair, regeneration, and transplantation. J Bone Joint Surg Am. 1997;79-A:612–632
  7. Chérin E, Saï A, Laugier P, Netter P, Berger G. Evaluation of acoustical parameter sensitivity to age-related and osteoarthritic changes in articular cartilage using 50-MHz ultrasound. Ultrasound Med Biol. 1998;24:341–354
  8. Chiang EH, Laing TJ, Meyer CR, Boes JL, Rubin JM, Adler RS. Ultrasonic characterization of in vitro osteoarthritic articular cartilage with validation by confocal microscopy. Ultrasound Med Biol. 1997;23:205–213
  9. Disler DG, Raymond E, May DA, Wayne JS, McCauley TR. Articular cartilage defects: in vitro evaluation of accuracy and interobserver reliability for detection and grading with US. Radiology. 2000;215:846–851
  10. Glüer CC, Blake G, Lu Y, Blunt BA, Jergas M, Genant HK. Accurate assessment of precision errors: how to measure the reproducibility of bone densitometry techniques. Osteoporos Int. 1995;5:262–270
  11. Grassi W, Salaffi F, Filippucci E. Ultrasound in rheumatology. Best Pract Res Clin Rheumatol. 2005;19:467–485
  12. Hans D, Dargent-Molina P, Schott AM, Sebert JL, Cormier C, Kotzki PO, et al. Ultrasonographic heel measurements to predict hip fracture in elderly women: The EPIDOS prospective study. Lancet. 1996;348:511
  13. Hattori K, Mori K, Habata T, Takakura Y, Ikeuchi K. Measurement of the mechanical condition of articular cartilage with an ultrasonic probe: Quantitative evaluation using wavelet transformation. Clin Biomech (Bristol, Avon). 2003;18:553–557
  14. Hattori K, Takakura Y, Morita Y, Takenaka M, Uematsu K, Ikeuchi K. Can ultrasound predict histological findings in regenerated cartilage?. Rheumatology (Oxford). 2004;43:302–305
  15. Hattori K, Ikeuchi K, Morita Y, Takakura Y. Quantitative ultrasonic assessment for detecting microscopic cartilage damage in osteoarthritis. Arthritis Res Ther. 2005;7:R38–R46
  16. Hattori K, Takakura Y, Ishimura M, Tanaka Y, Habata T, Ikeuchi K. Differential acoustic properties of early cartilage lesions in living human knee and ankle joints. Arthritis Rheum. 2005;52:3125–3131
  17. Hunziker EB. Articular cartilage repair: Basic science and clinical progress. A review of the current status and prospects. Osteoarthritis Cartilage. 2002;10:432–463
  18. Joiner GA, Bogoch ER, Pritzker KP, Buschmann MD, Foster FS. Changes in acoustic parameters at 30 MHz of human and bovine cartilage following experimentally-induced matrix degradation to simulate early osteoarthritis. IEEE Ultrason Symp. 2000;2:1337–1340
  19. Joiner GA, Bogoch ER, Pritzker KP, Buschmann MD, Chevrier A, Foster FS. High frequency acoustic parameters of human and bovine articular cartilage following experimentally-induced matrix degradation. Ultrason Imaging. 2001;23:106–116
  20. Jurvelin J, Kuusela T, Heikkilä R, Pelttari A, Kiviranta I, Tammi M, et al. Investigation of articular cartilage surface morphology with a semiquantitative scanning electron microscopic method. Acta Anat. 1983;116:302–311
  21. Kiviranta P, Töyräs J, Nieminen MT, Laasanen MS, Saarakkala S, Nieminen HJ, et al. Comparison of novel clinically applicable methodology for sensitive diagnostics of cartilage degeneration. Eur Cell Mater. 2007;13:46–55discussion 55
  22. Laasanen MS, Saarakkala S, Töyräs J, Rieppo J, Jurvelin JS. Site-specific ultrasound reflection properties and superficial collagen content of bovine knee articular cartilage. Phys Med Biol. 2005;50:3221–3233
  23. Laasanen MS, Töyräs J, Vasara A, Saarakkala S, Hyttinen MM, Kiviranta I, et al. Quantitative ultrasound imaging of spontaneous repair of porcine cartilage. Osteoarthritis Cartilage. 2006;14:258–263
  24. Mankin HJ, Lippiello L. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. J Bone Joint Surg Am. 1970;52:424–434
  25. Mankin HJ, Thrasher AZ. Water content and binding in normal and osteoarthritic human cartilage. J Bone Joint Surg Am. 1975;57:76–80
  26. Maroudas AI. Balance between swelling pressure and collagen tension in normal and degenerate cartilage. Nature. 1976;260:808–809
  27. Minns RJ, Steven FS, Hardinge K. Osteoarthrotic articular cartilage lesions of the femoral head observed in the scanning electron microscope. J Pathol. 1977;122:63–70
  28. Nieminen HJ, Töyräs J, Rieppo J, Nieminen MT, Hirvonen J, Korhonen R, et al. Real-time ultrasound analysis of articular cartilage degradation in vitro. Ultrasound Med Biol. 2002;28:519–525
  29. Nissen SE, Yock P. Intravascular ultrasound: novel pathophysiological insights and current clinical applications. Circulation. 2001;103:604–616
  30. Qvist P, Bay-Jensen AC, Christiansen C, Dam EB, Pastoureau P, Karsdal MA. The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon?. Pharmacol Res. 2008;58:1–7
  31. Saarakkala S, Töyräs J, Hirvonen J, Laasanen MS, Lappalainen R, Jurvelin JS. Ultrasonic quantitation of superficial degradation of articular cartilage. Ultrasound Med Biol. 2004;30:783–792
  32. Saarakkala S, Laasanen MS, Jurvelin JS, Töyräs J. Quantitative ultrasound imaging detects degenerative changes in articular cartilage surface and subchondral bone. Phys Med Biol. 2006;51:5333–5346
  33. Saïed A, Chérin E, Gaucher H, Laugier P, Gillet P, Floquet J, et al. Assessment of articular cartilage and subchondral bone: Subtle and progressive changes in experimental osteoarthritis using 50 MHz echography in vitro. J Bone Miner Res. 1997;12:1378–1386
  34. Töyräs J, Rieppo J, Nieminen MT, Helminen HJ, Jurvelin JS. Characterization of enzymatically induced degradation of articular cartilage using high frequency ultrasound. Phys Med Biol. 1999;44:2723–2733
  35. Wilhjelm JE, Pedersen PC, Jacobsen SM. The influence of roughness, angle, range, and transducer type on the echo signal from planar interfaces. IEEE Trans Ultrason Ferroelectr Freq Control. 2001;48:511–521

PII: S0301-5629(09)00155-0

doi: 10.1016/j.ultrasmedbio.2009.04.004

Ultrasound in Medicine and Biology
Volume 35, Issue 9 , Pages 1546-1554 , September 2009

Article Tools

* Image Usage & Resolution