Ultrasound in Medicine and Biology
Volume 35, Issue 7 , Pages 1086-1091 , July 2009

The Relationship between Enhanced Intensity and Microvessel Density of Gastric Carcinoma Using Double Contrast-Enhanced Ultrasonography

  • Li Shiyan

      Affiliations

    • Department of Ultrasonography, The 2nd Affiliated Hospital of Wenzhou Medical College, Zhejiang, China
  • ,
  • Huang Pintong

      Affiliations

    • Department of Ultrasonography, The 2nd Affiliated Hospital of Wenzhou Medical College, Zhejiang, China
    • Corresponding Author InformationAddress correspondence to: Huang Pintong, Department of Ultrasonography, The 2nd Affiliated Hospital of Wenzhou Medical College, Zhejiang, China.
  • ,
  • Wang Zongmin

      Affiliations

    • Department of Pathology, The 2nd Affiliated Hospital of Wenzhou Medical College, Zhejiang, China
  • ,
  • Huang Fuguang

      Affiliations

    • Department of Ultrasonography, The 2nd Affiliated Hospital of Wenzhou Medical College, Zhejiang, China
  • ,
  • Zheng Zhiqiang

      Affiliations

    • Department of Gastrointestinal Surgery, The 2nd Affiliated Hospital of Wenzhou Medical College, Zhejiang, China
  • ,
  • Yang Yan

      Affiliations

    • Department of Ultrasonography, The 2nd Affiliated Hospital of Wenzhou Medical College, Zhejiang, China
  • ,
  • David Cosgrove

      Affiliations

    • Imaging Sciences Department, Imperial College, Hammersmith Hospital, London, UK

Received 9 January 2009 ,Revised 24 February 2009 ,Accepted 9 March 2009.

References 

  1. Albo D, Granick MS, Jhala N, Atkinson B, Solomon MP. The relationship of angiogenesis to biological activity in human squamous cell carcinomas of the head and neck. Ann Plast Surg. 1994;32:588–594
  2. Anthony PP, Ramani P. Endothelial markers in malignant vascular tumours of the liver: Superiority of QB-END/10 over von Willebrand factor and Ulex europaeus agglutinin 1. J Clin Pathol. 1991;44:29–32
  3. Barr RG. Ultrasound contrast. Oral and i.v. agents amplify the image. Diagn Imaging (San Franc). 1999;21:56–61
  4. Bosari S, Lee AK, DeLellis RA, Wiley BD, Heatley GJ, Silverman ML. Microvessel quantitation and prognosis in invasive breast carcinoma. Hum Pathol. 1992;23:755–761
  5. Brasch RC, Weinmann HJ, Wesbey GE. Contrast-enhanced NMR imaging: Animal studies using gadolinium-DTPA complex. AJR Am J Roentgenol. 1984;142:625–630
  6. Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature. 2000;407:249–257
  7. Chan AO, Luk JM, Hui WM, Lam SK. Molecular biology of gastric carcinoma: From laboratory to bedside. J Gastroenterol Hepatol. 1999;14:1150–1160
  8. Chen CN, Cheng YM, Lin MT, Hsieh FJ, Lee PH, Chang KJ. Association of color Doppler vascularity index and microvessel density with survival in patients with gastric cancer. Ann Surg. 2002;235:512–518
  9. Corella D, Guillen M. Dietary habits and epidemiology of gastric carcinoma. Hepatogastroenterology. 2001;48:1537–1543
  10. Cui S, Hano H, Sakata A, Harada T, Liu T, Takai S, et al. Enhanced CD34 expression of sinusoid-like vascular endothelial cells in hepatocellular carcinoma. Pathol Int. 1996;46:751–756
  11. Du JR, Jiang Y, Zhang YM, Fu H. Vascular endothelial growth factor and microvascular density in esophageal and gastric carcinomas. World J Gastroenterol. 2003;9:1604–1606
  12. Ferlay J, Bray F, Pisani P, Parkin DM. GLOBOCAN 2002: Cancer Incidence, Mortality and Prevalence Worldwide. IARC CancerBase N°5, versión 2.0. Lyon: IARC Press; 2004;
  13. Folkman J. Tumor angiogenesis: Therapeutic implications. N Engl J Med. 1971;285:1182–1186
  14. Folkman J. What is the evidence that tumors are angiogenesis dependent?. J Natl Cancer Inst. 1990;82:4–6
  15. Folkman J, Cole P, Zimmerman S. Tumor behavior in isolated perfused organs: In vitro growth and metastases of biopsy material in rabbit thyroid and canine intestinal segment. Ann Surg. 1966;164:491–502
  16. Folkman J, Klagsbrun M. Angiogenic factors. Science. 1987;235:442–447
  17. Folkman J, Watson K, Ingber D, Hanahan D. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature. 1989;339:58–61
  18. Fukumura D, Jain RK. Role of nitric oxide in angiogenesis and microcirculation in tumors. Cancer Metastasis Rev. 1998;17:77–89
  19. Greaves MF, Brown J, Molgaard HV, Spurr NK, Robertson D, Delia D, et al. Molecular features of CD34: A hemopoietic progenitor cell-associated molecule. Leukemia. 1992;6(Suppl 1):31–36
  20. Harisinghani MG, Saini S, Schima W, McNicholas M, Mueller PR. Simethicone coated cellulose as an oral contrast agent for ultrasound of the upper abdomen. Clinical Radiology. 1997;52:224–226
  21. Kaneko T, Konno H, Baba M, Tanaka T, Nakamura S. Urokinase-type plasminogen activator expression correlates with tumor angiogenesis and poor outcome in gastric cancer. Cancer Sci. 2003;94:43–49
  22. Lassau N, Lamuraglia M, Chami L, Leclere J, Bonvalot S, Terrier P, et al. Gastrointestinal stromal tumors treated with imatinib: Monitoring response with contrast-enhanced sonography. AJR Am J Roentgenol. 2006;187:1267–1273
  23. Li HX, Chang XM, Song ZJ, He SX. Correlation between expression of cyclooxygenase-2 and angiogenesis in human gastric adenocarcinoma. World J Gastroenterol. 2003;9:674–677
  24. Liekens S, De Clercq E, Neyts J. Angiogenesis: Regulators and clinical applications. Biochem Pharmacol. 2001;61:253–270
  25. Liotta LA, Saidel MG, Kleinerman J. The significance of hematogenous tumor cell clumps in the metastatic process. Cancer Res. 1976;36:889–894
  26. Nagy JA, Brown LF, Senger DR, Lanir N, Van de Water L, Dvorak AM, et al. Pathogenesis of tumor stroma generation: A critical role for leaky blood vessels and fibrin deposition. Biochim Biophys Acta. 1989;948:305–326
  27. Nakajima Y, Gotanda T, Uchimiya H, Furukawa T, Haraguchi M, Ikeda R, et al. Inhibition of metastasis of tumor cells overexpressing thymidine phosphorylase by 2-deoxy-L-ribose. Cancer Res. 2004;64:1794–1801
  28. Nuernberg D, Ignee A, Dietrich CF. Current status of ultrasound in gastroenterology—Bowel and upper gastrointestinal tract: Part 1. Z Gastroenterol. 2007;45:629–640
  29. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74–108
  30. Parkin DM, Whelan SL, Ferlay J, Storm H. Cancer incidence in five continents. Vol. VIII. IARC Sci Pub. 2002;1–781
  31. Peng SH, Deng H, Yang JF, Xie PP, Li C, Li H, et al. Significance and relationship between infiltrating inflammatory cell and tumor angiogenesis in hepatocellular carcinoma tissues. World J Gastroenterol. 2005;11:6521–6524
  32. Phillips P, Gardner E. Contrast-agent detection and quantification. Eur Radiol. 2004;14(Suppl 8):P4–P10
  33. Porschen R, Classen S, Piontek M, Borchard F. Vascularization of carcinomas of the esophagus and its correlation with tumor proliferation. Cancer Res. 1994;54:587–591
  34. Ruck P, Xiao JC, Kaiserling E. Immunoreactivity of sinusoids in hepatocellular carcinoma. An immunohistochemical study using lectin UEA-1 and antibodies against endothelial markers, including CD34. Arch Pathol Lab Med. 1995;119:173–178
  35. Sanz-Ortega J, Steinberg SM, Moro E, Saez M, Lopez JA, Sierra E, et al. Comparative study of tumor angiogenesis and immunohistochemistry for p53, c-ErbB2, c-myc and EGFr as prognostic factors in gastric cancer. Histol Histopathol. 2000;15:455–462
  36. Schneider M. SonoVue, a new ultrasound contrast agent. Eur Radiol. 1999;9(Suppl 3):S347–S348
  37. Schneider M, Arditi M, Barrau MB, Brochot J, Broillet A, Ventrone R, et al. BR1: A new ultrasonographic contrast agent based on sulfur hexafluoride-filled microbubbles. Invest Radiol. 1995;30:451–457
  38. Simmons DL, Satterthwaite AB, Tenen DG, Seed B. Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells. J Immunol. 1992;148:267–271
  39. Strich G, Hagan PL, Gerber KH, Slutsky RA. Tissue distribution and magnetic resonance spin lattice relaxation effects of gadolinium-DTPA. Radiology. 1985;154:723–726
  40. Tanigawa N, Lu C, Mitsui T, Miura S. Quantitation of sinusoid-like vessels in hepatocellular carcinoma: Its clinical and prognostic significance. Hepatology. 1997;26:1216–1223
  41. Teifke A, Behr O, Schmidt M, Victor A, Vomweg TW, Thelen M, et al. Dynamic MR imaging of breast lesions: Correlation with microvessel distribution pattern and histologic characteristics of prognosis. Radiology. 2006;239:351–360
  42. Wang JH, Min PQ, Wang PJ, Cheng WX, Zhang XH, Wang Y, et al. Dynamic CT evaluation of tumor vascularity in renal cell carcinoma. AJR Am J Roentgenol. 2006;186:1423–1430
  43. Wang Z, Tang J, An L, Wang W, Luo Y, Li J, et al. Contrast-enhanced ultrasonography for assessment of tumor vascularity in hepatocellular carcinoma. J Ultrasound Med. 2007;26:757–762
  44. Weidner N. Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors. Breast Cancer Res Treat. 1995;36:169–180
  45. Weidner N, Folkman J, Pozza F, Bevilacqua P, Allred EN, Moore DH, et al. Tumor angiogenesis: A new significant and independent prognostic indicator in early-stage breast carcinoma. J Natl Cancer Inst. 1992;84:1875–1887
  46. Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis—Correlation in invasive breast carcinoma. N Engl J Med. 1991;324:1–8
  47. Williams JK, Carlson GW, Cohen C, Derose PB, Hunter S, Jurkiewicz MJ. Tumor angiogenesis as a prognostic factor in oral cavity tumors. Am J Surg. 1994;168:373–380

PII: S0301-5629(09)00110-0

doi: 10.1016/j.ultrasmedbio.2009.03.010

Ultrasound in Medicine and Biology
Volume 35, Issue 7 , Pages 1086-1091 , July 2009