Ultrasound in Medicine and Biology
Volume 35, Issue 8 , Pages 1367-1375 , August 2009

Differences in Acoustic Properties of Intact and Degenerated Human Patellar Cartilage During Compression

  • Panu Kiviranta

      Affiliations

    • Department of Physics, University of Kuopio, Kuopio, Finland
    • Corresponding Author InformationAddress correspondence to: Panu Kiviranta, M.D., Department of Physics, University of Kuopio, P.O. Box 1627, FI-70211 Kuopio, Finland.
    • ,
  • Eveliina Lammentausta

      Affiliations

    • Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
    • ,
  • Juha Töyräs

      Affiliations

    • Department of Physics, University of Kuopio, Kuopio, Finland
    • Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland
    • ,
  • Heikki J. Nieminen

      Affiliations

    • Department of Physics, University of Kuopio, Kuopio, Finland
    • ,
  • Petro Julkunen

      Affiliations

    • Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland
    • ,
  • Ilkka Kiviranta

      Affiliations

    • Department of Orthopaedics and Traumatology, University of Helsinki, Helsinki, Finland
    • Department of Orthopaedics and Traumatology, Jyväskylä Central Hospital, Jyväskylä, Finland
    • ,
  • Jukka S. Jurvelin

      Affiliations

    • Department of Physics, University of Kuopio, Kuopio, Finland

Received 3 December 2008 ,Revised 21 February 2009 ,Accepted 4 March 2009.

References 

  1. Altman RD, Gold GE. Atlas of individual radiographic features in osteoarthritis, revised. Osteoarthritis Cartilage. 2007;15(Suppl. A):A1–A56
  2. Altman RD, Hochberg MC, Moskowitz RW, Schnitzer TJ. Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Arthritis Rheum. 2000;43:1905–1915
  3. Appleyard RC, Swain MV, Khanna S, Murrel GAC. The accuracy and reliability of a novel handheld dynamic indentation probe for analysing articular cartilage. Phys Med Biol. 2001;46:541–550
  4. Blalock HM. Social statistics. New York: McGraw-Hill; 1972;
  5. Brown CP, Hughes SW, Crawford RW, Oloyede A. Ultrasound assessment of articular cartilage: Analysis of the frequency profile of reflected signals from naturally and artificially degraded samples. Connect Tissue Res. 2007;48:277–285
  6. Brown H, Prescott R. Applied mixed models in medicine. Hoboken, New Jersey: Wiley; 2006;
  7. Buckwalter JA, Mankin HJ. Articular cartilage, part II: Degeneration and osteoarthritis, repair, regeneration, and transplantation. J Bone Joint Surg. 1997;79:612–632
  8. Burstein D, Gray M. New MRI techniques for imaging cartilage. J Bone Joint Surg. 2003;85-A:70-77
  9. Camacho NP, West P, Torzilli PA, Mendelsohn R. FTIR microscopic imaging of collagen and proteoglycan in bovine cartilage. Biopolymers. 2001;62:1–8
  10. Challis RE, Kitney RI. Biomedical signal processing (in four parts). Part 1. Time-domain methods. Med Biol Eng Comput. 1990;28:509–524
  11. Cherin E, Saied A, Laugier P, Netter P, Berger G. Evaluation of acoustical parameter sensitivity to age-related and osteoarthritic changes in articular cartilage using 50-MHz ultrasound. Ultrasound Med Biol. 1998;24:341–354
  12. Conaghan P, Birrel F, Burke M, Cumming J, Dickson J, Dieppe P, et al. Osteoarthritis: National clinical guideline for care and management in adults. London: NICE, Royal College of Physicians; 2008;
  13. Dashefsky JH. Arthroscopic measurement of chondromalacia of patella cartilage using a microminiature pressure transducer. Arthroscopy. 1987;3:80–85
  14. Elders MJ. The increasing impact of arthritis on public health. J Rheumatol Suppl. 2000;60:6–8
  15. Goldring MB. Update on the biology of the chondrocyte and new approaches to treating cartilage diseases. Best Pract Res Clin Rheumatol. 2006;20:1003–1025
  16. Goss SA, O'Brien WD. Direct ultrasonic velocity measurement of mammalian collagen threads. J Acoust Soc Am. 1979;65:507–511
  17. Hattori K, Ikeuchi K, Morita Y, Takakura Y. Quantitative ultrasonic assessment for detecting microscopic cartilage damage in osteoarthritis. Arthritis Res Ther. 2005;7:R38–R46
  18. Hattori K, Takakura Y, Ishimura M, Habata T, Uematsu K, Ikeuch K. Quantitative arthroscopic ultrasound evaluation of living human cartilage. Clin Biomech (Bristol, Avon). 2004;19:213–216
  19. Hayes WC, Keer LM, Herrmann G, Mockros LF. A mathematical analysis for indentation tests of articular cartilage. J Biomech. 1972;5:541–551
  20. Herrmann JM, Pitris C, Bouma BE, Boppart SA, Jesser CA, Stamper DL, et al. High resolution imaging of normal and osteoarthritic cartilage with optical coherence tomography. J Rheumatol. 1999;26:627–635
  21. Kaleva E, Saarakkala S, Töyräs J, Nieminen HJ, Jurvelin JS. In vitro comparison of time-domain, frequency-domain and wavelet ultrasound parameters in diagnostics of cartilage degeneration. Ultrasound Med Biol. 2008;34:155–159
  22. Kallioniemi AS, Jurvelin JS, Nieminen MT, Lammi MJ, Töyräs J. Contrast agent enhanced pQCT of articular cartilage. Phys Med Biol. 2007;52:1209–1219
  23. Király K, Lapveteläinen T, Arokoski J, Törrönen K, Modis L, Kiviranta I, et al. Application of selected cationic dyes for the semiquantitative estimation of glycosaminoglycans in histological sections of articular cartilage by microspectrophotometry. Histochem J. 1996;28:577–590
  24. Kiviranta P, Lammentausta E, Töyräs J, Kiviranta I, Jurvelin JS. Indentation diagnostics of cartilage degeneration. Osteoarthritis Cartilage. 2008;16:796–804
  25. Kiviranta P, Töyräs J, Nieminen MT, Laasanen MS, Saarakkala S, Nieminen HJ, et al. Comparison of novel clinically applicable methodology for sensitive diagnostics of cartilage degeneration. Eur Cell Mater. 2007;13:46–55discussion 55
  26. Laasanen MS, Saarakkala S, Töyräs J, Hirvonen J, Rieppo J, Korhonen RK, et al. Ultrasound indentation of bovine knee articular cartilage in situ. J Biomech. 2003;36:1259–1267
  27. Laasanen MS, Saarakkala S, Töyräs J, Rieppo J, Jurvelin JS. Site-specific ultrasound reflection properties and superficial collagen content of bovine knee articular cartilage. Phys Med Biol. 2005;50:3221–3233
  28. Laasanen MS, Töyräs J, Hirvonen J, Saarakkala S, Korhonen RK, Nieminen MT, et al. Novel mechano-acoustic technique and instrument for diagnosis of cartilage degeneration. Physiol Meas. 2002;23:491–503
  29. Lees S, Heeley JD, Ahern JM, Oravecz MG. Axial phase velocity in rat tail tendon fibers at 100 MHz by ultrasonic microscopy. IEEE Trans Sonic Ultrason. 1983;30:85–90
  30. Legare A, Garon M, Quardo R, Savard P, Poole AR, Buschmann MD. Detection and analysis of cartilage degeneration by spatially resolved streaming potentials. J Orthop Res. 2002;20:819–826
  31. Ling HY, Zheng YP, Patil SG. Strain dependence of ultrasound speed in bovine articular cartilage under compression in vitro. Ultrasound Med Biol. 2007;33:1599–1608
  32. Lyyra T, Jurvelin J, Pitkänen P, Väätäinen U, Kiviranta I. Indentation instrument for the measurement of cartilage stiffness under arthroscopic control. Med Eng Phys. 1995;17:395–399
  33. Lyyra T, Kiviranta I, Väätäinen U, Helminen HJ, Jurvelin JS. In vivo characterization of indentation stiffness of articular cartilage in the normal human knee. J Biomed Mat Res. 1999;48:482–487
  34. Lötjönen P, Julkunen P, Töyräs J, Lammi MJ, Jurvelin JS, Nieminen HJ. Strain-dependent modulation of ultrasound speed in articular cartilage under dynamic compression. Ultrasound Med Biol. 2009;
  35. Malemud CJ, Islam N, Haqqi TM. Pathophysiological mechanisms in osteoarthritis lead to novel therapeutic strategies. Cells Tissues Organs. 2003;174:34–48
  36. Niederauer MQ, Cristante S, Niederauer GM, Wilkes RP, Singh SM, Messina DF, et al. A novel instrument for quantitatively measuring the stiffness of articular cartilage. Trans Orthopaed Res Soc. 1998;23:905
  37. Nieminen HJ, Julkunen P, Töyräs J, Jurvelin JS. Ultrasound speed in articular cartilage under mechanical compression. Ultrasound Med Biol. 2007;33:1755–1766
  38. Nieminen HJ, Saarakkala S, Laasanen MS, Hirvonen J, Jurvelin JS, Töyräs J. Ultrasound attenuation in normal and spontaneously degenerated articular cartilage. Ultrasound Med Biol. 2004;30:493–500
  39. Nieminen HJ, Töyräs J, Laasanen MS, Jurvelin JS. Acoustic properties of articular cartilage under mechanical stress. Biorheology. 2006;43:523–535
  40. Palmer AW, Guldberg RE, Levenston ME. Analysis of cartilage matrix fixed charge density and three-dimensional morphology via contrast-enhanced microcomputed tomography. Proc Natl Acad Sci U S A. 2006;103:19255–19260
  41. Palmoski MJ, Brandt KD. Running inhibits the reversal of atrophic changes in canine knee cartilage after removal of a leg cast. Arthritis Rheum. 1981;24:1329–1337
  42. Pellaumail B, Watrin A, Loeuille D, Netter P, Berger G, Laugier P, et al. Effect of articular cartilage proteoglycan depletion on high frequency ultrasound backscatter. Osteoarthritis Cartilage. 2002;10:535–541
  43. Potter K, Kidder LH, Levin IW, Lewis EN, Spencer RG. Imaging of collagen and proteoglycan in cartilage sections using Fourier transform infrared spectral imaging. Arthritis Rheum. 2001;44:846–855
  44. Pritzker KP, Gay S, Jimenez SA, Ostergaard K, Pelletier JP, Revell PA, et al. van den Berg WB. Osteoarthritis cartilage histopathology: Grading and staging. Osteoarthritis Cartilage. 2006;14:13–29
  45. Saarakkala S, Korhonen RK, Laasanen MS, Töyräs J, Rieppo J, Jurvelin JS. Mechano-acoustic determination of Young's modulus of articular cartilage. Biorheology. 2004;41:167–179
  46. Saarakkala S, Töyräs J, Hirvonen J, Laasanen MS, Lappalainen R, Jurvelin JS. Ultrasonic quantitation of superficial degradation of articular cartilage. Ultrasound Med Biol. 2004;30:783–792
  47. Setton LA, Mow VC, Muller FJ, Pita JC, Howell DS. Mechanical properties of canine articular cartilage are significantly altered following transection of the anterior cruciate ligament. J Orthopaed Res. 1994;12:451–463
  48. Suh JK, Youn I, Fu FH. An in situ calibration of an ultrasound transducer: A potential application for an ultrasonic indentation test of articular cartilage. J Biomech. 2001;34:1347–1353
  49. Töyräs J, Laasanen MS, Saarakkala S, Lammi MJ, Rieppo J, Kurkijärvi J, et al. Speed of sound in normal and degenerated bovine articular cartilage. Ultrasound Med Biol. 2003;29:447–454
  50. Töyräs J, Rieppo J, Nieminen MT, Helminen HJ, Jurvelin JS. Characterization of enzymatically induced degradation of articular cartilage using high frequency ultrasound. Phys Med Biol. 1999;44:2723–2733
  51. Yelin E, Callahan LF. The economic cost and social and psychological impact of musculoskeletal conditions. National Arthritis Data Work Groups. Arthritis Rheum. 1995;38:1351–1362
  52. Zhang W, Moskowitz RW, Nuki G, Abrahamson S, Altman RD, Arden N, et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part I: Critical appraisal of existing treatment guidelines and systematic review of current research evidence. Osteoarthritis Cartilage. 2007;15:981–1000
  53. Zhang W, Moskowitz RW, Nuki G, Abrahamson S, Altman RD, Arden N, et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage. 2008;16:137–162
  54. Zheng YP, Bridal SL, Shi J, Saied A, Lu MH, Jaffre B, et al. High resolution ultrasound elastomicroscopy imaging of soft tissues: System development and feasibility. Phys Med Biology. 2004;49:3925–3938
  55. Zheng YP, Mak AF. An ultrasound indentation system for biomechanical properties assessment of soft tissues in vivo. IEEE Trans Biomed Eng. 1996;43:912–918
  56. Zheng YP, Mak AF, Lau KP, Qin L. An ultrasonic measurement for in vitro depth-dependent equilibrium strains of articular cartilage in compression. Phys Med Biol. 2002;47:3165–3180
  57. Zheng YP, Niu HJ, Arthur Mak FT, Huang YP. Ultrasonic measurement of depth-dependent transient behaviors of articular cartilage under compression. J Biomech. 2005;38:1830–1837

PII: S0301-5629(09)00103-3

doi: 10.1016/j.ultrasmedbio.2009.03.003

Ultrasound in Medicine and Biology
Volume 35, Issue 8 , Pages 1367-1375 , August 2009

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