Ultrasound in Medicine and Biology
Volume 35, Issue 7 , Pages 1127-1138 , July 2009

Characterization of Acoustic Properties of PVA-Shelled Ultrasound Contrast Agents: Linear Properties (Part I)

  • Dmitry Grishenkov

      Affiliations

    • Marcus Wallenberg Laboratory, Royal Institute of Technology, Stockholm, Sweden
    • Corresponding Author InformationAddress correspondence to: Dmitry Grishenkov, Marcus Wallenberg Laboratory, Royal Institute of Technology, Teknikringen 8, 100 44 Stockholm, Sweden.
    • ,
  • Claudio Pecorari

      Affiliations

    • ÅF Kontroll AB, Ågatan, Linköping, Sweden
    • ,
  • Torkel B. Brismar

      Affiliations

    • CLINTEC, Department of Radiology, Karolinska University Hospital, Huddinge, Sweden
    • ,
  • Gaio Paradossi

      Affiliations

    • Dipartimento di Chimica, Università di Roma Tor Vergata, Rome, Italy

Received 23 July 2008 ,Revised 27 January 2009 ,Accepted 9 February 2009.

References 

  1. Bloch SH, Wan M, Dayton PA, Ferrara KW. Optical observation of lipid- and polymer shelled ultrasound microbubble contrast agents. Appl Phys Lett. 2004;84:631–633
  2. Bouakaz A, Versluis M, De Jong N. High-speed optical observations of contrast agent destruction. Ultrasound Med Biol. 2005;31:391–399
  3. Cavalieri F, El Hamassi A, Chiessi E, Paradossi G. Stable polymeric microballoons as multifunctional device for biomedical uses: Synthesis and characterization. Langmuir. 2005;21:8758–8764
  4. Cavalieri F, A El Hamassi A, Chiessi E, Paradossi G, Villa R, Zaffaroni N. Tethering functional ligands onto shell of ultrasound active polymeric microbubbles. Biomacromolecules. 2006;7:604–611
  5. Church C. The effect of an elastic solid surface layer on the radial pulsations of gas bubbles. J Acoust Soc Am. 1995;97:1510–1521
  6. Commander KW, Prosperetti A. Linear pressure waves in bubbly liquids: Comparison between theory and experiments. J Acoust Soc Am. 1989;85:732–746
  7. Dijkmans PA, Juffermans LJM, Musters RJP, van Wamel A, ten Cate FJ, van Gilst W, et al. Microbubbles and ultrasound: From diagnosis to therapy. Eur J Echocardiogr. 2004;5:245–256
  8. Doinikov AA, Dayton PA. Maxwell rheological model for lipid-shelled ultrasound microbubble contrast agents. J Acoust Soc Am. 2007;121:3331–3340
  9. Ferry JD. Viscoelastic properties of polymers. New York: John Wiley & Sons, Inc; 1961;
  10. Frinking PJA, de Jong N. Acoustic modeling of shell-encapsulated gas bubbles. Ultrasound Med Biol. 1998;24:523–533
  11. Gao Z, Kennedy AM, Christensen DA, Rapoport NY. Drug-loaded nano/microbubbles for combining ultrasonography and targeted chemotherapy. Ultrasonics. 2008;48:260–270
  12. Gittes F, MacKintosh FC. Dynamic shear modulus of a semiflexible polymer network. Phys Rev E. 1998;58:R1241–R1244
  13. Hoff L, Sontum PC, Hovem JM. Oscillations of polymeric microbubbles: Effect of the encapsulating shell. J Acoust Soc Am. 2000;107:2272–2280
  14. Koenderink GH, Atakhorrami M, MacKintosh FC, Schmidt CF. High-frequency stress relaxation in semiflexible polymer solutions and networks. Phys Rev Lett. 2006;96:138307
  15. Lathia JD, Leodore L, Wheatley MA. Polymeric contrast agent with targeting potential. Ultrasonics. 2004;42:763–768
  16. Lavisse S, Rouffiac V, Peronneau P, Paci A, Chaix C, Reb P, et al. Acoustic characterization of a new trisacryl contact agent. Part I: In vitro study. Ultrasonics. 2008;48:16–25
  17. Marmottant P, Meer S, Emmer M, Versluis M, de Jong N, Hilgenfeldt S, et al. A model for large amplitude oscillations of coated bubbles accounting for buckling and rupture. J Acoust Soc Am. 2005;118:3499–3505
  18. Morse DC. Viscoelasticity of concentrated isotropic solutions of semiflexible polymers. 2. linear response. Macromolecules. 1998;31:7044–7067
  19. Morse DC. Viscoelasticity of tightly entangled solutions of semiflexible polymers. Phys Rev E. 1998;58:R1237–R1240
  20. Nozaki T, Ogawa R, Watanabe A, Nishio R, Fuse H, Kondo T. Ultrasound-mediated gene transfection: Problems to be solved and future possibilities. J Med Ultrason. 2006;33:135–142
  21. Paradossi G, Cavalieri F, Chiessi E, Ponassi V, Martorana V. Tailoring of physical and chemical properties of macro- and microhydrogels based on telechelic PVA. Biomacromolecules. 2002;3:1255–1262
  22. Raisinghani A, DeMaria AN. Physical principles of microbubble ultrasound contrast agents. Am J Cardiol. 2002;90:3J–7J
  23. Sarkar K, Shi WT, Chatterjee D, Forsberg F. Characterization of ultrasound contrast microbubbles using in vitro experiments and viscous and viscoelastic interface model for encapsulation. J Acoust Soc Am. 2005;118:539–550
  24. Shankar V, Pasquali M, Morse DC. Theory of linear viscoelasticity of semiflexible rods in dilute solution. J Rheology. 2002;46:1111–1154
  25. Tortora G, Grabowski SR. Introduction to the human body. New York: John Wiley & Sons, Inc; 2001;
  26. Tzvetkov G, Graf B, Fernandes P, Fery A, Cavalieri F, Paradossi G, et al. Soft matter in situ characterization of gas-filled microballoons using soft X-ray microspectroscopy. Soft Matter. 2008;4:510–514
  27. Wheatley MA, Forsberg F, Oum K, Ro R, El-Sherif D. Comparison of in vitro and in vivo acoustic response of a novel 50:50 PLGA contrast agents. Ultrasonics. 2006;44:360–367

PII: S0301-5629(09)00071-4

doi: 10.1016/j.ultrasmedbio.2009.02.002

Ultrasound in Medicine and Biology
Volume 35, Issue 7 , Pages 1127-1138 , July 2009

Article Tools

* Image Usage & Resolution