Ultrasound in Medicine and Biology
Volume 35, Issue 7 , Pages 1119-1126 , July 2009

Spatial Distribution of Ultrasound Targeted Microbubble Destruction Increases Cardiac Transgene Expression But Not Capillary Permeability

Received 13 April 2008 ,Revised 31 December 2008 ,Accepted 26 January 2009.

References 

  1. Ay T, Havaux X, Van Camp G, Campanelli B, Gisellu G, Pasquet A, et al. Destruction of contrast microbubbles by ultrasound: Effects on myocardial function, coronary perfusion pressure, and microvascular integrity. Circulation. 2001;104:461–466
  2. Bekeredjian R, Chen S, Frenkel P, Grayburn PA, Shohet RV. Ultrasound targeted microbubble destruction can repeatedly direct highly specific plasmid expression to the heart. Circulation. 2003;108:1022–1026
  3. Bekeredjian R, Chen S, Pan W, Grayburn PA, Shohet RV. Effects of ultrasound-targeted microbubble destruction on cardiac gene expression. Ultrasound Med Biol. 2004;30:539–543
  4. Bekeredjian R, Grayburn PA, Shohet RV. Use of ultrasound contrast agents for gene or drug delivery in cardiovascular medicine. J Am Coll Cardiol. 2005;45:329–335
  5. Bekeredjian R, Hansen A, Filusch A, Dubart AE, Da Silva KG, Hardt SS, et al. Cyclic variation of myocardial signal intensity in real-time myocardial perfusion imaging. J Am Soc Echocardiogr. 2002;15:1425–1431
  6. Bekeredjian R, Katus HA, Kuecherer HF. Therapeutic use of ultrasound targeted microbubble destruction: A review of noncardiac applications. Ultraschall Med. 2006;27:134–140
  7. Bekeredjian R, Kroll RD, Fein E, Tinkov S, Coester C, Winter G, et al. Ultrasound targeted microbubble destruction increases capillary permeability in hepatomas. Ultrasound Med Biol. 2007;33:1592–1598
  8. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248–254
  9. Brujan EA. The role of cavitation microjets in the therapeutic applications of ultrasound. Ultrasound Med Biol. 2004;30:381–387
  10. Chen S, Shohet RV, Bekeredjian R, Frenkel P, Grayburn PA. Optimization of ultrasound parameters for cardiac gene delivery of adenoviral or plasmid deoxyribonucleic acid by ultrasound-targeted microbubble destruction. J Am Coll Cardiol. 2003;42:301–308
  11. Christiansen JP, French BA, Klibanov AL, Kaul S, Lindner JR. Targeted tissue transfection with ultrasound destruction of plasmid-bearing cationic microbubbles. Ultrasound Med Biol. 2003;29:1759–1767
  12. Hirokawa T, Karshafian R, Pavlin CJ, Burns PN. Insonation of the eye in the presence of microbubbles: preliminary study of the duration and degree of vascular bioeffects—Work in progress. Ultrasound Med. 2007;26:731–738
  13. Hoffmann R, Borges AC, Kasprzak JD, von Bardeleben S, Firschke C, Greis C, et al. Analysis of myocardial perfusion or myocardial function for detection of regional myocardial abnormalities. An echocardiographic multicenter comparison study using myocardial contrast echocardiography and 2D echocardiography. Eur J Echocardiogr. 2007;8:438–448
  14. Leong-Poi H, Le E, Rim SJ, Sakuma T, Kaul S, Wei K. Quantification of myocardial perfusion and determination of coronary stenosis severity during hyperemia using real-time myocardial contrast echocardiography. J Am Soc Echocardiogr. 2001;14:1173–1182
  15. Li P, Armstrong WF, Miller DL. Impact of myocardial contrast echocardiography on vascular permeability: comparison of three different contrast agents. Ultrasound Med Biol. 2004;30:83–91
  16. Li P, Cao LQ, Dou CY, Armstrong WF, Miller D. Impact of myocardial contrast echocardiography on vascular permeability: An in vivo dose response study of delivery mode, pressure amplitude and contrast dose. Ultrasound Med Biol. 2003;29:1341–1349
  17. Masugata H, Lafitte S, Peters B, Strachan GM, DeMaria AN. Comparison of real-time and intermittent triggered myocardial contrast echocardiography for quantification of coronary stenosis severity and transmural perfusion gradient. Circulation. 2001;104:1550–1556
  18. Mayer S, Grayburn PA. Myocardial contrast agents: Recent advances and future directions. Prog Cardiovasc Dis. 2001;44:33–44
  19. Miller DL, Driscoll EM, Dou C, Armstrong WF, Lucchesi BR. Microvascular permeabilization and cardiomyocyte injury provoked by myocardial contrast echocardiography in a canine model. J Am Coll Cardiol. 2006;47:1464–1468
  20. Miller DL, Quddus J. Sonoporation of monolayer cells by diagnostic ultrasound activation of contrast agent gas bodies. Ultrasound Med Biol. 2000;26:661–667
  21. Pitt WG, Husseini GA, Staples BJ. Ultrasonic drug delivery–A general review. Expert Opin Drug Deliv. 2004;1:37–56
  22. Müller OJ, Schinkel S, Kleinschmidt JA, Katus HA, Bekeredjian R. Augmentation of AAV-mediated cardiac gene transfer after systemic administration in adult rats. Gene Ther. 2008;15:1558–1565
  23. Postema M, van Wamel A, Lancee CT, de Jong N. Ultrasound-induced encapsulated microbubble phenomena. Ultrasound Med Biol. 2004;30:827–840
  24. Shohet RV, Chen S, Zhou YT, Wang Z, Meidell RS, Unger RH, et al. Echocardiographic destruction of albumin microbubbles directs gene delivery to the myocardium. Circulation. 2000;101:2554–2556
  25. Timperley J, Mitchell AR, Thibault H, Mirza IH, Becher H. Safety of contrast dobutamine stress echocardiography: A single center experience. J Am Soc Echocardiogr. 2005;18:163–167
  26. Tsutsui JM, Grayburn PA, Xie F, Porter TR. Drug and gene delivery and enhancement of thrombolysis using ultrasound and microbubbles. Cardiol Clin. 2004;22:299–312
  27. Vannan M, McCreery T, Li P, Han Z, Unger E, Kuersten B, et al. Ultrasound-mediated transfection of canine myocardium by intravenous administration of cationic microbubble-linked plasmid DNA. J Am Soc Echocardiogr. 2002;15:214–218

PII: S0301-5629(09)00029-5

doi: 10.1016/j.ultrasmedbio.2009.01.008

Ultrasound in Medicine and Biology
Volume 35, Issue 7 , Pages 1119-1126 , July 2009