Ultrasound in Medicine and Biology
Volume 34, Issue 12 , Pages 1893-1900 , December 2008

Contrast Sonography Enables Noninvasive and Quantitative Assessment of Neovascularization After Stem Cell Transplantation

  • Kentaro Otani

      Affiliations

    • Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Japan
    • The Japan Health Science Foundation, Tokyo, Japan
  • ,
  • Shunsuke Ohnishi

      Affiliations

    • Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Japan
  • ,
  • Hiroaki Obata

      Affiliations

    • Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Japan
  • ,
  • Osamu Ishida

      Affiliations

    • Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Japan
  • ,
  • Soichiro Kitamura

      Affiliations

    • Department of Cardiovascular Surgery, National Cardiovascular Center, Suita, Japan
  • ,
  • Noritoshi Nagaya

      Affiliations

    • Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Japan
    • Corresponding Author InformationAddress correspondence to: Noritoshi Nagaya, MD, PhD, Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan

Received 17 December 2007 ,Revised 7 April 2008 ,Accepted 24 April 2008.

References 

  1. Bragadeesh T, Sari I, Pascotto M, Micari A, Kaul S, Lindner JR. Detection of peripheral vascular stenosis by assessing skeletal muscle flow reserve. J Am Coll Cardiol. 2005;45:780–785
  2. Dawson D, Vincent MA, Barrett EJ, Kaul S, Clark A, Leong-Poi H, et al. Vascular recruitment in skeletal muscle during exercise and hyperinsulinemia assessed by contrast ultrasound. Am J Physiol Endocrinol Metab. 2002;282:E714–E720
  3. Dijkmans PA, Senior R, Becher H, Porter TR, Wei K, Visser CA, et al. Myocardial contrast echocardiography evolving as a clinically feasible technique for accurate rapid, and safe assessment of myocardial perfusion: the evidence so far. J Am Coll Cardiol. 2006;48:2168–2177
  4. Durdu S, Akar AR, Arat M, Sancak T, Eren NT, Ozyurda U. Autologous bone-marrow mononuclear cell implantation for patients with Rutherford grade II-III thromboangiitis obliterans. J Vasc Surg. 2006;44:732–739
  5. Essex TJH, Byrne PO. A laser Doppler scanner for imaging blood flow in skin. J Biomed Eng. 1999;13:189–194
  6. Freedman SB, Isner JM. Therapeutic angiogenesis for ischemic cardiovascular disease. J Mol Cell Cardiol. 2001;33:379–393
  7. Fujii H, Tomita S, Nakatani T, Fukuhara S, Hanatani A, Ohtsu Y, et al. A novel application of myocardial contrast echocardiography to evaluate angiogenesis by autologous bone marrow cell transplantation in chronic ischemic pig model. J Am Coll Cardiol. 2004;43:1299–1305
  8. Hakkinen JP, Miller MW, Smith AH, Knight DR. Measurement of organ blood flow with coloured microspheres in the rat. Cardiovasc Res. 1995;29:74–79
  9. Hughes GC, Annex BH. Angiogenic therapy for coronary artery and peripheral arterial disease. Expert Rev Cardiovasc Ther. 2005;3:521–535
  10. Iba O, Matsubara H, Nozawa Y, Fujiyama S, Amano K, Mori Y, et al. Angiogenesis by implantation of peripheral blood mononuclear cells and platelets into ischemic limbs. Circulation. 2002;106:2019–2025
  11. Iwase T, Nagaya N, Fujii T, Itoh T, Ishibashi-Ueda H, Yamagishi M, et al. Adrenomedullin enhances angiogenic potency of bone marrow transplantation in a rat model of hindlimb ischemia. Circulation. 2005;111:356–362
  12. Iwase T, Nagaya N, Fujii T, Itoh T, Murakami S, Matsumoto T, et al. Comparison of angiogenic potency between mesenchymal stem cells and mononuclear cells in a rat model of hindlimb ischemia. Cardiovasc Res. 2005;66:543–551
  13. Jayaweera AR, Edwards N, Glasheen WP, Villanueva FS, Abbott RD, Kaul S. In vivo myocardial kinetics of air-filled albumin microbubbles during myocardial contrast echocardiography: Comparison with radiolabeled red blood cells. Circ Res. 1994;74:1157–1165
  14. Kirkpatrick JN, Wong T, Bednarz JE, Spencer KT, Sugeng L, Ward RP, et al. Differential diagnosis of cardiac masses using contrast echocardiographic perfusion imaging. J Am Coll Cardiol. 2004;43:1412–1419
  15. Kuersten B, Murthy TH, Li P, Liu Z, Locricchio E, Baisch C, et al. Ultraharmonic myocardial contrast imaging: in vivo experimental and clinical data from a novel technique. J Am Soc Echocardiogr. 2001;14:910–916
  16. Leong-Poi H, Christiansen J, Heppner P, Lewis CW, Klibanov AL, Kaul S, et al. Assessment of endogenous and therapeutic arteriogenesis by contrast ultrasound molecular imaging of integrin expression. Circulation. 2005;111:3248–3254
  17. Losordo DW, Dimmeler S. Therapeutic angiogenesis and vasculogenesis for ischemic disease part II: Cell-based therapies. Circulation. 2004;109:2692–2697
  18. Masugata H, Fujita N, Kondo I, Peters B, Ohmori K, Mizushige K, et al. Assessment of right ventricular perfusion after right coronary artery occlusion by myocardial contrast echocardiography. J Am Coll Cardiol. 2003;41:1823–1830
  19. Miyahara Y, Nagaya N, Kataoka M, Yanagawa B, Tanaka K, Hao H, et al. Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nat Med. 2006;12:459–465
  20. Mori H, Hyodo K, Tobita K, Chujo M, Shinozaki Y, Sugishita Y, et al. Visualization of penetrating transmural arteries in situ by monochromatic synchrotron radiation. Circulation. 1994;89:863–871
  21. Murohara T, Ikeda H, Duan J, Shintani S, Sasaki K, Eguchi H, et al. Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization. J Clin Invest. 2000;105:1527–1536
  22. Nagaya N, Kangawa K, Itoh T, Iwase T, Murakami S, Miyahara Y, et al. Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation. 2005;112:1128–1135
  23. Otani K, Masuda K, Asanuma T, Ishikura F, Beppu S. Corrected quantification method to determine myocardial blood flow using real-time myocardial contrast echocardiography. J Am Soc Echocardiogr. 2006;19:973–981
  24. Pittenger MF, Martin BJ. Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res. 2004;95:9–20
  25. Saigawa T, Kato K, Ozawa T, Toba K, Makiyama Y, Minagawa S, et al. Clinical application of bone marrow implantation in patients with arteriosclerosis obliterans, and the association between efficacy and the number of implanted bone marrow cells. Circ J. 2004;68:1189–1193
  26. Shintani S, Murohara T, Ikeda H, Ueno T, Sasaki K, Duan J, et al. Augmentation of postnatal neovascularization with autologous bone marrow transplantation. Circulation. 2001;103:897–903
  27. Tateishi-Yuyama E, Matsubara H, Murohara T, Ikeda U, Shintani S, Masaki H, et al. Therapeutic angiogenesis for patients with limb ischemia by autologous transplantation of bone-marrow cells: A pilot study and a randomized controlled trial. Lancet. 2002;360:427–435
  28. Wei K, Jayaweera AR, Firoozan S, Linka A, Skyba DM, Kaul S. Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion. Circulation. 1998;97:473–483

PII: S0301-5629(08)00203-2

doi: 10.1016/j.ultrasmedbio.2008.04.014

Ultrasound in Medicine and Biology
Volume 34, Issue 12 , Pages 1893-1900 , December 2008