Ultrasound in Medicine and Biology
Volume 34, Issue 7 , Pages 1049-1052 , July 2008

Phalangeal Quantitative Ultrasound in Children with Phenylketonuria: A Pilot Study

  • Francesco Porta

      Affiliations

    • Department of Pediatrics, University of Torino, Torino, Italy
    • Corresponding Author InformationAddress correspondence to: Dr. Francesco Porta, Department of Pediatrics, University of Torino, Piazza Polonia 94, 10126 Torino, Italy.
    • ,
  • Marco Spada

      Affiliations

    • Department of Pediatrics, University of Torino, Torino, Italy
    • ,
  • Roberto Lala

      Affiliations

    • Pediatric Endocrinology, Ospedale Infantile Regina Margherita, Torino, Italy
    • ,
  • Alessandro Mussa

      Affiliations

    • Department of Pediatrics, University of Torino, Torino, Italy

Received 28 June 2007 ,Revised 12 December 2007 ,Accepted 19 December 2007.

References 

  1. Allen JR, Humphries IR, Waters DL, Roberts DC, Lipson AH, Howman-Giles RG, et al. Decreased bone mineral density in children with phenylketonuria. Am J Clin Nutr. 1994;59:419–422
  2. Al-Qadreh A, Schulpis KH, Athanasopoulou H, Mengreli C, Skarpalezou A, Voskaki I. Bone mineral status in children with phenylketonuria under treatment. Acta Paediatr. 1998;87:1162–1166
  3. Barat P, Barthe N, Redonnet-Vernhet I, Parrot F. The impact of the control of serum phenylalanine levels on osteopenia in patients with phenylketonuria. Eur J Pediatr. 2002;161:687–688
  4. Barkmann R, Lusse S, Stampa B, Sakata S, Heller M, Gluer CC. Assessment of the geometry of human finger phalanges using quantitative ultrasound in vivo. Osteoporos Int. 2000;11:745–755
  5. Baroncelli GI, Federico G, Bertelloni S, Sodini F, De Terlizzi F, Cadossi R, et al. Assessment of bone quality by quantitative ultrasound of proximal phalanges of the hand and fracture rate in children and adolescents with bone and mineral disorders. Pediatr Res. 2003;54:125–136
  6. Baroncelli GI, Federico G, Vignolo M, Valerio G, del Puente A, Maghnie M, et al. Cross-sectional reference data for phalangeal quantitative ultrasound from early childhood to young-adulthood according to gender, age, skeletal growth, and pubertal development. Bone. 2006;39:159–173
  7. Cacciari E, Milani S, Balsamo A, Spada E, Bona G, Cavallo L, et al. Italian cross-sectional growth charts for height, weight and BMI (2 to 20 yr). J Endocrinol Invest. 2006;29:581–593
  8. Dalle Carbonare L, Giannini S. Bone microarchitecture as an important determinant of bone strength. J Endocrinol Invest. 2004;27:99–105
  9. De Terlizzi F, Battista S, Cavani F, Cane V, Cadossi R. Influence of bone tissue density and elasticity on ultrasound propagation: An in vitro study. J Bone Miner Res. 2000;15:2458–2466
  10. Greeves LG, Carson DJ, Magee A, Patterson CC. Fractures and phenylketonuria. Acta Paediatr. 1997;86:242–244
  11. Hillman L, Schlotzhauer C, Lee D, Grasela J, Witter S, Allen S, et al. Decreased bone mineralization in children with phenylketonuria under treatment. Eur J Pediatr. 1996;155(Suppl 1):S148–S152
  12. Landin LA. Fracture patterns in children (Analysis of 8,682 fractures with special reference to incidence, etiology and secular changes in a Swedish urban population 1950–1979). Acta Orthop Scand Suppl. 1983;202:1–109
  13. MacDonald A, Chakrapani A, Hendriksz C, Daly A, Davies P, Asplin D, et al. Protein substitute dosage in PKU: How much do young patients need?. Arch Dis Child. 2006;91:588–593
  14. McMurry MP, Chan GM, Leonard CO, Ernst SL. Bone mineral status in children with phenylketonuria—Relationship to nutritional intake and phenylalanine control. Am J Clin Nutr. 1992;55:997–1004
  15. Montagnani A, Gonnelli S, Cepollaro C, Bruni D, Franci MB, Lucani B, et al. Graphic trace analysis of ultrasound at the phalanges may differentiate between subjects with primary hyperparathyroidism and with osteoporosis: A pilot study. Osteoporos Int. 2002;13:222–227
  16. Montagnani A, Gonnelli S, Cepollaro C, Mangeri M, Monaco R, Bruni D, et al. Quantitative ultrasound at the phalanges in healthy Italian men. Osteoporos Int. 2000;11:499–504
  17. Mussa A, Porta F, Gianoglio B, Gaido M, Nicolosi MG, De Terlizzi F, et al. Bone alterations in children and young adults with renal transplant assessed by phalangeal quantitative ultrasound. Am J Kidney Dis. 2007;50:441–449
  18. Njeh CF, Hans D, Fuerst T, Gluer CC, Genant HK. Quantitative Ultrasound (Assessment of Osteoporosis and Bone Status). London: Martin Dunitz; 1999;
  19. Sakata S, Barkmann R, Lochmuller EM, Heller M, Gluer CC. Assessing bone status beyond BMD: Evaluation of bone geometry and porosity by quantitative ultrasound of human finger phalanges. J Bone Miner Res. 2004;19:924–930
  20. Schwahn B, Mokov E, Scheidhauer K, Lettgen B, Schonau E. Decreased trabecular bone mineral density in patients with phenylketonuria measured by peripheral quantitative computed tomography. Acta Paediatr. 1998;87:61–63
  21. Scriver CR, Kaufman S. Hyperphenylalaninemia: Phenylalanine hydroxylase deficiency. In:  Scriver CR,  Beaudet AL,  Valle D editor. The Metabolic and Molecular Bases of Inherited Disease. New York: McGraw-Hill; 2001;p. 1667–1724
  22. Yannicelli S, Medeiros DM. Elevated plasma phenylalanine concentrations may adversely affect bone status of phenylketonuric mice. J Inherit Metab Dis. 2002;25:347–361
  23. Wuster C, Albanese C, De Aloysio D, Duboeuf F, Gambacciani M, Gonnelli S, et al. Phalangeal osteosonogrammetry study: Age-related changes, diagnostic sensitivity, and discrimination power (The Phalangeal Osteosonogrammetry Study Group). J Bone Miner Res. 2000;15:1603–1614

PII: S0301-5629(07)00657-6

doi: 10.1016/j.ultrasmedbio.2007.12.013

Ultrasound in Medicine and Biology
Volume 34, Issue 7 , Pages 1049-1052 , July 2008

Article Tools

* Image Usage & Resolution