Ultrasound in Medicine and Biology
Volume 34, Issue 5 , Pages 693-717 , May 2008

Simulation and Validation of Arterial Ultrasound Imaging and Blood Flow

  • Peter R. Hoskins

      Affiliations

    • Corresponding Author InformationAddress correspondence to: P. R. Hoskins, Medical Physics Section, University of Edinburgh, Chancellors Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.

Received 21 August 2007 ,Revised 18 October 2007 ,Accepted 26 October 2007.

References 

  1. Aarts PAMM, van der Broek SAT, Prins GW, Kulken GDC, Sixma JJ, Heethar RM. Blood platelets are concentrated near the wall and red blood cells, in the centre of flowing blood. Arteriosclerosis. 1988;8:819–824
  2. Adrian RJ. Particle-imaging techniques for experimental fluid-mechanics. Annu Rev Fluid Mech. 1991;23:261–304
  3. AIUM. Performance criteria and measurements for Doppler ultrasound devices. American Institute of Ultrasound in Medicine; 1993;
  4. AIUM. Performance Criteria and Measurements for Doppler Ultrasound Devices: Technical Discussion. 2nd ed.. 2002;
  5. Augst AD, Barratt DC, Hughes AD, Glor FP, Thom SAM, Xu XY. Accuracy and reproducibility of CFD predicted wall shear stress using 3D ultrasound images. J Biomech Eng Trans ASME. 2003;125:218–222
  6. Augst AD, Barratt DC, Hughes AD, Thom SAM, Xu XY. Various issues relating to computational fluid dynamics simulations of carotid bifurcation flow based on models reconstructed from three-dimensional ultrasound images. Proc Inst Mech Eng H-J Eng Med. 2003;217:393–403
  7. Baker DW, Yates WG. Technique for studying sample volume of ultrasonic Doppler devices. Med Biol Eng. 1973;11:766–770
  8. Baldewsing RA, de Korte CL, Schaar JA, Mastik F, van Der Steen AFW. A finite element model for performing intravascular ultrasound elastography of human atherosclerotic coronary arteries. Ultrasound Med Biol. 2004;30:803–813
  9. Baldewsing RA, Mastik F, Schaar JA, Serruys PW, van der Steen AFW. Young's modulus reconstruction of vulnerable atherosclerotic plaque components using deformable curves. Ultrasound Med Biol. 2006;32:201–210
  10. Bale-Glickman J, Selby K, Saloner D, Savas O. Experimental flow studies in exact-replica phantoms of atherosclerotic carotid bifurcations under steady input conditions. J Biomech Eng Trans ASME. 2003;125:38–48
  11. Bamber JC, Hill CR, King JA, Dunn F. Ultrasonic propagation through fixed and unfixed tissues. Ultrasound Med Biol. 1979;5:159–165
  12. Barnett SB, Ter Haar GR, Ziskin MC, Rott HD, Duck FA, Maeda K. International recommendations and guidelines for the safe use of diagnostic ultrasound in medicine. Ultrasound Med Biol. 2000;26:355–366
  13. Bascom PAJ, Cobbold RSC, Routh HF, Johnston KW. On the Doppler signal from a steady flow asymmetrical stenosis model—Effects of turbulence. Ultrasound Med Biol. 1993;19:197–210
  14. Bascom PAJ, Johnston KW, Cobbold RSC, Ojha M. Relation of the flow field distal to a moderate stenosis to the Doppler power. Ultrasound Med Biol. 1997;23:25–39
  15. Bastos CA, Fish PJ. A Doppler signal simulator. Clin Phys Physiol Meas. 1991;12:177–183
  16. Bharadvaj BK, Mabon RF, Giddens DP. Steady flow in a model of the human carotid bifurcation. 1 (Flow visualization). J Biomech. 1982;15:349–362
  17. Bharadvaj BK, Mabon RF, Giddens DP. Steady flow in a model of the human carotid bifurcation. 2 (Laser-Doppler anemometer measurements). J Biomech. 1982;15:363–378
  18. Blake JR, Meagher SC, Fraser KH, Easson WJ, Hoskins PR. A method to estimate wall shear rate with clinical ultrasound scanners. Ultrasound Med Biol (in press).
  19. Bluth EI, Stavros AT, Marich KW, Aufrichtig D, Marich KW, Baker JD. Carotid duplex sonography: A multicenter recommendation for standardised imaging and Doppler criteria. Radiographics. 1988;8:487–506
  20. Bohs LN, Friemel BH, Trahey GE. Experimental velocity profiles and volumetric flow via 2-dimensional speckle tracking. Ultrasound Med Biol. 1995;21:885–898
  21. Boote EJ, Zagzebski JA. Performance tests of Doppler ultrasound equipment with a tissue and blood mimicking phantom. J Ultrasound Med. 1988;7:137–147
  22. Boussion N, Soulez G, De Guise JA, Daronat M, Qin Z, Cloutier G. Geometrical accuracy and fusion of multimodal vascular images: A phantom study. Med Phys. 2004;31:1434–1443
  23. Brands PJ, Hoeks APG, Hofstra L, Reneman RS. Noninvasive method to estimate wall shear rate using ultrasound. Ultrasound Med Biol. 1995;21:171–185
  24. Browne JE, Ramnarine KV, Watson AJ, Hoskins PR. Assessment of the acoustic properties of common tissue-mimicking test phantoms. Ultrasound Med Biol. 2003;29:1053–1060
  25. Browne JE, Watson AJ, Hoskins PR, Elliott AT. Validation of a sensitivity performance index test protocol and evaluation of colour Doppler sensitivity for a range of ultrasound scanners. Ultrasound Med Biol. 2004;30:1475–1483
  26. Brusseau E, Fromageau J, Finet G, Delachartre P, Vray D. Axial strain imaging of intravascular data: Results on polyvinyl alcohol cryogel phantoms and carotid artery. Ultrasound Med Biol. 2001;27:1631–1642
  27. Burlew MM, Madsen EL, Zagzebski JA, Banjovc RA, Sum SW. A new tissue equivalent material. Radiology. 1980;134:517–520
  28. Butler MB, Moran CM, Anderson T, Cunningham C, Ross JA, Easson WJ, et al. Laser Doppler anemometry measurements of the shear stresses on ultrasonic contrast agent microbubbles attached to agar. Ultrasound Med Biol. 2005;31:545–552
  29. Calil SJ, Roberts VC. Detection of low-grade arterial-stenosis using an automatic minimum-flow-velocity tracking system (MVTS) as an adjunct to pulsed ultrasonic Doppler vessel imaging. Med Biol Eng Comput. 1985;23:311–323
  30. Caro CG, Pedley TJ, Schroter RC, Seed WA. The Mechanics of the Circulation. In: Oxford: Oxford University Press; 1978;p. 47–48
  31. Caro CG, Pedley TJ, Schroter RC, Seed WA. The Mechanics of the Circulation. In: Oxford: Oxford University Press; 1978;p. 385–399
  32. Cathignol D, Dickerson K, Newhouse VL, Faure P, Chaperon JY. On the spectral properties of Doppler thread phantoms. Ultrasound Med Biol. 1994;20:601–610
  33. Chu KC, Rutt BK. Polyvinyl alcohol cryogel: An ideal phantom material for MR studies of arterial flow and elasticity. Magn Res Med. 1997;37:314–319
  34. Claassen L, Seidel G, Algermissen C. Quantification of flow rates using harmonic grey-scale imaging and an ultrasound contrast agent: An in vitro and in vivo study. Ultrasound Med Biol. 2001;27:83–88
  35. Cloutier G, Qin Z, Garcia D, Soulez G, Oliva V, Durand LG. Assessment of arterial stenosis in a flow model with power Doppler angiography: Accuracy and observations on blood echogenicity. Ultrasound Med Biol. 2000;26:1489–1501
  36. Cloutier G, Soulez G, Qanadli SD, Teppaz P, Allard L, Qin Z, et al. A multimodality vascular imaging phantom with fiducial markers visible in DSA, CTA, MRA, and ultrasound. Med Phys. 2004;31:1424–1433
  37. Couch GG, Johnston KW, Ojha M. Full-field flow visualization and velocity measurement with a photochromic grid method. Meas Sci Technol. 1996;7:1238–1246
  38. Dabrowski W, DunmoreBuyze J, Rankin RN, Holdsworth DW, Fenster A. A real vessel phantom for imaging experimentation. Med Phys. 1997;24:687–693
  39. Dabrowski W, Dunmore-Buyze J, Cardinal HN, Fenster A. A real vessel phantom for flow imaging: 3-D Doppler ultrasound of steady flow. Ultrasound Med Biol. 2001;27:135–141
  40. Daigle RJ, Stavros AT, Lee RM. Overestimation of velocity and frequency values by multi-element linear array Dopplers. J Vasc Technol. 1990;14:206–213
  41. de Korte CL, Cespedes EI, van der Steen AFW, Lancee CT. Intravascular elasticity imaging using ultrasound: Feasibility studies in phantoms. Ultrasound Med Biol. 1997;23:735–746
  42. de Korte CL, Pasterkamp G, van der Steen AFW, Woutman HA, Bom N. Characterization of plaque components with intravascular ultrasound elastography in human femoral and coronary arteries in vitro. Circulation. 2000;102:617–623
  43. Deane CR, Markus HS. Colour velocity flow measurement: In vitro validation and application to human carotid arteries. Ultrasound Med Biol. 1997;23:447–452
  44. Dineley J, Meagher S, Poepping TL, McDicken WN, Hoskins PR. Design and characterisation of a wall motion phantom. Ultrasound Med Biol. 2006;32:1349–1357
  45. Dineley JA, McDicken WN, Hoskins PR. Factors affecting the arterial distension waveform derived from Tissue Doppler Imaging (TDI): An in-vitro study on precision. Ultrasound Med Biol. 2007;33:1123–1131
  46. Douville Y, Johnston KW, Kassam M, Zuech P, Cobbold RSC, Jares A. An invitro model and its application for the study of carotid Doppler spectral broadening. Ultrasound Med Biol. 1983;9:347–356
  47. Duck FA. Medical and non-medical protection standards for ultrasound and infrasound. Prog Biophys Molec Biol. 2007;93:176–191
  48. Eriksson R, Persson HW, Dymling SO, Lindstrom K. A microcirculation phantom for performance testing of blood perfusion measurement equipment. Eur J Ultrasound. 1995;2:65–75
  49. Evans DH, McDicken WN. Doppler Ultrasound. In: 2nd ed.. Chichester: Wiley; 2000;p. 288–310
  50. Evans JA, Price R, Luhana F. A novel testing device for Doppler ultrasound equipment. Phys Med Biol. 1989;34:1701–1708
  51. Fei DY, Billian C, Rittgers SE. Flow dynamics in a stenosed carotid bifurcation model. 1 (Basic velocity-measurements). Ultrasound Med Biol. 1988;14:21–31
  52. Ferrara KW, Algazi VR. A statistical-analysis of the received signal from blood during laminar-flow. IEEE Trans Ultrason Ferroelectr Freq Control. 1994;41:185–198
  53. Fish PJ, Steel R. Summary report on phase 1 of EC project: “Validation of a flow Doppler test object for diagnostic ultrasound scanners.”. 1996;University of Wales, Bangor
  54. Fleming AD, McDicken WN, Sutherland G, Hoskins PR. Assessment of colour Doppler tissue imaging using test objects. Ultrasound Med Biol. 1994;20:937–951
  55. Fontaine I, Cloutier G, Allard L. Non-Gaussian statistical property of the ultrasonic Doppler signal downstream of a severe stenosis. Ultrasound Med Biol. 1997;23:41–45
  56. Foster FS, Obara H, Bloomfield T, Ryan LK, Lockwood GR. Ultrasound backscatter from blood in the 30 to 70 MHz frequency range. Ultrasonic Symp Proc. 1994;3:1599–1602
  57. Fraser KH, Poepping TL, McNeilly A, Megson IL, Hoskins PR. Acoustic speed and attenuation coefficient in sheep aorta measured at 5-9 MHz. Ultrasound in Med Biol. 2006;32:971–980
  58. Frayne R, Gowman LM, Rickey DW, Holdsworth DW, Picot PA, Drangova M, et al. A geometrically accurate vascular phantom for comparative studies of x-ray, ultrasound, and magnetic resonance vascular imaging: Construction and geometrical verification. Med Phys. 1993;20:415–425
  59. Friedman MH. Arteriosclerosis research using vascular flow models—From 2-d branches to compliant replicas. J Biomech Eng Trans ASME-B. 1993;115:595–601
  60. Fromageau J, Brusseau E, Vray D, Gimenez G, Delachartre P. Characterization of PVA cryogel for intravascular ultrasound elasticity imaging. IEEE Trans Ultrason Ferroelectr Freq Control. 2003;50:1318–1324
  61. Fromageau J, Germisson JL, Schmitt C, Maurice RL, Mongrain R, Cloutier G. Estimation of polyvinyl alcohol cryogel mechanical properties with four ultrasound elastography methods and comparison with gold standard testings. IEEE Trans Ultrason Ferroelectr Freq Control. 2007;54:498–509
  62. Gatzoulis L, Ramnarine KV, Pye SD, Anderson T, Newby DE, Hoskins PR, et al. Doppler colour flow imaging and flow quantification with a novel forward-viewing intravascular ultrasound system. Ultrasound Med Biol. 2003;29:53–64
  63. Giddens DP, Khalifa AMA. Turbulence measurements with pulsed Doppler ultrasound employing a frequency tracking method. Ultrasound Med Biol. 1982;8:427–437
  64. Giddens DP, Zarins CK, Glagov S. The role of fluid mechanics in the localisation and detection of atherosclerosis. J Biomech Eng. 1993;115:588–594
  65. Gill RW. Pulsed Doppler with B-mode imaging for quantitative blood flow measurement. Ultrasound Med Biol. 1979;5:223–225
  66. Glor FP, Ariff B, Crowe LA, Hughes AD, Cheong PL, Thom SAM, et al. Carotid geometry reconstruction: A comparison between MRI and ultrasound. Med Phys. 2003;30:3251–3261
  67. Glor FP, Ariff B, Hughes AD, Verdonck PR, McG SA, Barratt DC, et al. Operator dependence of 3-D ultrasound-based computational fluid dynamics for the carotid bifurcation. IEEE Trans Med Imag. 2005;24:451–456
  68. Goertz DE, Needles A, Burns PN, Foster FS. High-frequency, nonlinear flow imaging of microbubble contrast agents. IEEE Trans Ultrason Ferroelectr Freq Cont. 2005;52:495–502
  69. Goldstein A. Performance tests of Doppler ultrasound equipment with a string phantom. J Ultrasound Med. 1991;10:125–139
  70. Guo Z, Fenster A. Three-dimensional power Doppler imaging: A phantom study to quantify vessel stenosis. Ultrasound Med Biol. 1996;22:1059–1069
  71. Guo ZY, Durand LG, Allard L, Cloutier G, Fenster A. In vitro evaluation of multiple arterial stenoses using three-dimensional power Doppler angiography. J Vasc Surg. 1998;27:681–688
  72. Hames TK, Nelligan BJ, Nelson RJ, Gazzard VM, Roberts J. The resolution of transcranial Doppler scanning: A method for in vitro evaluation. Clin Phys Physiol Meas. 1991;12:157–161
  73. Hammer S, Easson W, Hoskins PR. An arterial wall motion test phantom for the evaluation of wall motion software. Ultrasound Med Biol. 2007;33:1504–1511
  74. Hein IA, O'Brien WD. A flexible blood flow phantom capable of independently producing constant and pulsatile flow with predictable spatial flow profile for ultrasound measurement validation. IEEE Trans Biomed Eng. 1992;39:1111–1121
  75. Hindle AJ, Perkins AC. A perfusion phantom for the evaluation of contrast agents. Ultrasound Med Biol. 1994;20:309–314
  76. Hoeks APG, Ruissen CJ, Hicks P, Reneman RS. Methods to evaluate the sample volume of pulsed Doppler systems. Ultrasound Med Biol. 1984;10:427–434
  77. Holdsworth DW, Rickey DW, Drangova M, Miller DJM, Fenster A. Computer controlled positive displacement pump for physiological flow simulation. Med Biomed Eng Comput. 1991;20:565–570
  78. Hoskins PR, Anderson TA, McDicken WN. A computer controlled flow phantom for generation of physiological Doppler waveforms. Phys Med Biol. 1989;34:1709–1717
  79. Hoskins PR, Loupas T, McDicken WN. A comparison of the Doppler spectra from human blood and artificial blood used in a flow phantom. Ultrasound Med Biol. 1990;16:141–147
  80. Hoskins PR, Li SL, McDicken WN. Velocity estimation using duplex scanners. Ultrasound Med Biol. 1991;17:195–199
  81. Hoskins PR, McDicken WN. An investigation of simulated umbilical artery Doppler waveforms I (The effect of physical parameters on the maximum frequency envelope and on indices derived from the maximum frequency envelope). Ultrasound Med Biol. 1991;17:7–21
  82. Hoskins PR. Choice of moving target for a string phantom. I (Backscattered power characteristics). Ultrasound Med Biol. 1994;20:773–780
  83. Hoskins PR. Choice of moving target for a string phantom. II (On the testing of Doppler ultrasound devices). Ultrasound Med Biol. 1994;20:781–789
  84. Hoskins PR. Review of the design and use of flow phantoms. In:  Hoskins PR,  Evans JA,  Sheriff S editor. Testing of Doppler Ultrasound Equipment. York: IPEM; 1994;p. 12–29
  85. Hoskins PR, Fleming A, Stonebridge P, Allan PL, Cameron DC. Scan-plane vector maps and secondary flow motions. Eur J Ultrasound. 1994;1:159–169
  86. Hoskins PR. Accuracy of maximum velocity estimates made using Doppler ultrasound systems. Br J Radiol. 1996;69:172–177
  87. Hoskins PR, McDicken WN. Colour ultrasound imaging of blood flow and tissue motion. Br J Radiology. 1997;70:878–890
  88. Hoskins PR. Peak velocity estimation in arterial stenosis models using colour vector Doppler. Ultrasound Med Biol. 1997;23:889–897
  89. Hoskins PR. Measurement of blood velocity and related quantities using Doppler ultrasound. J Eng Med. 1999;213:391–400
  90. Hoskins PR, Fish PJ, Pye SD, Anderson T. Finite beam width ray model of geometric spectral broadening. Ultrasound Med Biol. 1999;25:391–404
  91. Hoskins PR, Ramnarine KV. Doppler test devices. In:  Evans DH,  McDicken WN editor. Doppler Ultrasound. 2nd ed.. Chichester: Wiley; 2000;p. 382–404
  92. Hoskins PR. Physical properties of tissues relevant to arterial ultrasound imaging and blood velocity measurement. Ultrasound Med Biol. 2007;33:1527–1539
  93. Hughes PE, How TV. Quantitative measurement of wall shear rate by pulsed Doppler ultrasound. J Med Eng Technol. 1993;17:58–64
  94. Hughes PE, How TV. Pulsatile velocity distribution and wall shear rate measurement using pulsed Doppler ultrasound. J Biomech. 1994;27:103–110
  95. IEC 1206. Ultrasonics—Continuous-wave Doppler systems: Test procedures. International Electrotechnical Commission, Geneva, Switzerland 1993.
  96. IEC 61895. Ultrasonics—Pulsed Doppler diagnostic systems: Test procedures to determine performance. International Electrotechnical Commission, Geneva, Switzerland, 1999.
  97. IEC 61685. Ultrasonics—Flow measurement systems: Flow test object. International Electrotechnical Commission, Geneva, Switzerland, 2001.
  98. IPEM. Report no. 70. In:  Hoskins PR,  Sherriff SB,  Evans JA editor. Testing of Doppler ultrasound equipment. York: IPEM; 1994;
  99. Jensen JA. Directional velocity estimation using focusing along the flow direction—I: Theory and simulation. IEEE Trans Ultrason Ferrorelectr Freq Control. 2003;50:857–872
  100. Jorgensen JE, Campau DN, Baker DW. Physical characteristics and mathematical modeling of pulsed ultrasonic flowmeter. Med Biol Eng. 1973;11:404–421
  101. Karino T, Goldsmith HL. Flow behaviour of blood cells and rigid spheres in an annular vortex. Phil Trans Royal Soc Lond Series B Biol Sci. 1977;279:413–445
  102. Kassam M, Johnston KW, Cobbold RSC. Quantitative estimation of spectral broadening for the diagnosis of carotid arterial disease: Method and in vitro results. Ultrasound Med Biol. 1985;11:425–433
  103. Kerber CW, Heilman CB. Flow dynamics in the human carotid-artery 1 (Preliminary-observations using a transparent elastic model). Am J Neuroradiol. 1992;13:173–180
  104. Khoshniat M, Thorne ML, Poepping TL, Hirji S, Holdsworth DW, Steinman DA. Real-time numerical simulation of Doppler ultrasound in the presence of nonaxial flow. Ultrasound Med Biol. 2005;31:519–528
  105. Kimme-Smith C, Hussain R, Duerinckx A, Tessler F, Grant E. Assurance of consistent peak-velocity measurements with a variety of duplex Doppler instruments. Radiology. 1990;177:265–272
  106. Komiyama N, Berry GJ, Kolz ML, Oshima A, Metz JA, Preuss P, et al. Tissue characterization of atherosclerotic plaques by intravascular ultrasound radiofrequency signal analysis: An in vitro study of human coronary arteries. Am Heart J. 2000;140:565–574
  107. Kripfgans OD, Rubin JM, Hall AL, Fowlkes JB. Vector Doppler imaging of a spinning disc ultrasound Doppler phantom. Ultrasound Med Biol. 2006;32:1037–1046
  108. Ku DN, Giddens DP. Pulsatile flow in a model carotid bifurcation. Arteriosclerosis. 1983;3:31–39
  109. Ku DN, Giddens DP, Phillips DJ, Strandness DE. Hemodynamics of the normal human carotid bifurcation—In vitro and in vivo studies. Ultrasound Med Biol. 1985;11:13–26
  110. Lange GJ, Loupas T. Spectral and color Doppler sonographic applications of a new test object with adjustable moving target spacing. J Ultrasound Med. 1996;15:775–784
  111. Law YF, Cobbold RSC, Johnston KW, Bascom PAJ. Computer controlled pulsatile pump system for physiological flow simulation. Med Biol Eng Comput. 1987;25:590–595
  112. Law YF, Johnston KW, Routh HF, Cobbold RSC. On the design and evaluation of a steady flow model for Doppler ultrasound studies. Ultrasound Med Biol. 1989;15:505–516
  113. Lerski RA, Duggan TC, Christie J. A simple tissue-like ultrasound phantom material. Br J Radiol. 1982;55:155–157
  114. Lesniak B, Kaluzynski K, Liepsch D, Palko T. The discrimination of stenosed carotid bifurcation models with smooth and irregular plaque surface (Part I. Laser and ultrasonic Doppler flow studies). Med Eng Phys. 2002;24:309–318
  115. Li SF, McDicken WN, Hoskins PR. An improved method for the measurement of vessel diameters using B-scan ultrasound devices. Clin Phys Physiol Meas. 1993;29:291–297
  116. Li SF, Hoskins PR, McDicken WN. Rapid measurement of the spatial resolution of colour flow scanners. Ultrasound Med Biol. 1997;23:591–596
  117. Li SF, Hoskins PR, Anderson T, McDicken WN. An acoustic injection system for colour flow imaging systems. Ultrasound Med Biol. 1998;24:161–164
  118. Li W, van der Steen AFW, Lancée CT, Céspedes I, Bom N. Blood flow imaging and volume flow quantitation with intravascular ultrasound. Ultrasound Med Biol. 1998;24:203–214
  119. Liepsch D, Pflugbeil G, Matsuo T, Lesniak B. Flow visualization and 1- and 3-D laser-Doppler-anemometer measurements in models of human carotid arteries. Clin Hemorheol Microcirc. 1998;18:1–30
  120. Lohmaier S, Ghanem A, Veltmann C, Sommer T, Bruce M, Tiemann K. In vitro and in vivo studies on continuous echo-contrast application strategies using Sonovue in a newly developed rotating pump setup. Ultrasound Med Biol. 2004;30:1145–1151
  121. Lubbers J. Application of a new blood-mimicking fluid in a flow Doppler test object. Eur J Ultrasound. 1999;9:267–276
  122. Lucidarme O, Franchi-Abella S, Correas JM, Bridal SL, Kurtisovski E, Berger G. Blood flow quantification with contrast-enhanced US: “Entrance in the section” phenomenon-phantom and rabbit study. Radiology. 2003;228:473–479
  123. Lunt MJ, Anderson R. Measurement of Doppler gate length using signal re-injection. Phys Med Biol. 1993;38:1631–1636
  124. Lupotti FA, Mastik F, Carlier SG, de Korte CL, van der Giessen WJ, Serruys PW, et al. Quantitative IVUS blood flow: Validation in vitro, in animals and in patients. Ultrasound Med Biol. 2003;29:507–515
  125. Madsen EL, Zagzebski JA, Frank GR. Oil in gelatin dispersions for use as ultrasonically tissue mimicking materials. Ultrasound Med Biol. 1982;8:277–287
  126. Mai JJ, Insana MF. Strain imaging of internal deformation. Ultrasound Med Biol. 2002;28:1475–1484
  127. Mai JJ, Lupotti FA, Insana MF. Vascular elasticity from regional displacement estimates. Ultrason Imag. 2003;25:171–192
  128. Mano I, Goshima H, Nambu M, Iio M. New polyvinyl-alcohol gel material for MRI phantoms. Magn Reson Med. 1986;3:921–926
  129. Moraczewski T, Tang HY, Shapley NC. Flow of a concentrated suspension through an abrupt axisymmetric expansion measured by nuclear magnetic resonance imaging. J Rheol. 2005;49:1409–1428
  130. Maurice RL, Brusseau E, Finet G, Cloutier G. On the potential of the Lagrangian speckle model estimator to characterize atherosclerotic plaques in endovascular elastography: In vitro experiments using an excised human carotid artery. Ultrasound Med Biol. 2005;31:85–91
  131. McCarty K, Locke DJ. Test objects for the assessment of the performance of Doppler shift flow meters. In:  Evans JA editors. Physics in Medical Ultrasound. London: IPSM; 1986;p. 94–106
  132. McDicken WN, Morrison DC, Smith DSA. A moving tissue equivalent phantom for ultrasonic real time scanning and Doppler techniques. Ultrasound Med Biol. 1983;9:455–459
  133. McDicken WN. A versatile test-object for the calibration of ultrasonic Doppler flow instruments. Ultrasound Med Biol. 1986;12:245–249
  134. McDonald DA. Blood Flow in Arteries. In: London: Edward Arnold; 1974;p. 111
  135. McAleavey S, Hah Z, Parker K. A thin film phantom for blood flow simulation and Doppler test. IEEE Trans Ultrason Ferroelectr Freq Control. 2001;48:737–742
  136. Meagher S, Blake J, Easson W, Hoskins PR. Validation of ultrasound velocity measurements against particle image velocimetry. Proc IASTED Int Conf Biomech. 2005;133–138
  137. Meagher S, Poepping TL, Ramnarine KV, Black RA, Hoskins PR. Anatomical flow phantoms of the nonplanar carotid bifurcation, part II (Experimental validation). Ultrasound Med Biol. 2007;33:303–310
  138. Meyer-Wiethe K, Cangur H, Seidel G. Comparison of different mathematical models to analyze diminution kinetics of ultrasound contrast enhancement in a flow phantom. Ultrasound Med Biol. 2005;31:93–98
  139. Michie DD, Fried WL. An in-vitro test medium for evaluating clinical Doppler ultrasonic flow systems. J Clin Ultrasound. 1973;1:130–133
  140. Motomiya M, Karino T. Flow patterns in the human carotid-artery bifurcation. Stroke. 1984;15:50–56
  141. Murgo JP, Col MC, Westerhof N, Giolma JP, Altobelli SA. Manipulation of ascending aortic pressure and flow waveform reflections with the Valsalva manoeuvre: Relationship to input impedance. Circulation. 1981;63:122–132
  142. Nadkarni SK, Austin H, Mills G, Boughner D, Fenster A. A pulsating coronary vessel phantom for two- and three-dimensional intravascular ultrasound studies. Ultrasound Med Biol. 2003;29:621–628
  143. Nair A, Kuban BD, Tuzcu EM, Schoenhagen P, Nissen SE, Vince DG. Coronary plaque classification with intravascular ultrasound radiofrequency data analysis. Circulation. 2002;106:2200–2206
  144. Newhouse VL, Nathan RS, Hertzler LW. A proposed standard target for ultrasound Doppler gain calibration. Ultrasound Med Biol. 1982;8:313–316
  145. Novario R, Goddi A, Crespi A, Conte L. A new phantom for quality assurance of color-coded ultrasound flow equipment. Physica Medica. 1994;10:101–106
  146. Oates CP. Towards an ideal blood analogue for Doppler ultrasound phantoms. Phys Med Biol. 1991;36:1433–1442
  147. Ojha M, Hummel RL, Cobbold RSC, Johnston KW. Development and evaluation of a high-resolution photochromic dye method for pulsatile flow studies. J Phys E-Sci Instr. 1988;21:998–1004
  148. Ojha M, Cobbold RSC, Johnston KW, Hummel RL. Pulsatile flow through constricted tubes—An experimental investigation using photochromic tracer methods. J Fluid Mech. 1989;203:173–197
  149. Ojha M, Johnston KW, Cobbold RSC, Hummel RL. Potential limitations of center-line pulsed Doppler recordings—An in vitro flow visualization study. J Vasc Surg. 1989;9:515–520
  150. Ojha M, Cobbold RSC, Johnston KW, Hummel RL. detailed visualization of pulsatile flow-fields produced by modeled arterial stenoses. J Biomed Eng. 1990;12:463–469
  151. Oung H, Forsberg F. Doppler ultrasound simulation model for pulsatile flow with nonaxial components. Ultrason Imag. 1996;18:157–172
  152. Paeng DG, Cao PJ, Shung KK. Doppler power variation from porcine blood under steady and pulsatile flow. Ultrasound Med Biol. 2001;27:1245–1254
  153. Patterson MS, Foster FS. The improvement and quantitative assessment of B-mode images produced by an annular array cone hybrid. Ultrason Imag. 1983;5:195–213
  154. Pedley TJ. The fluid mechanics of large blood vessels. Cambridge: Cambridge University Press; 1980;
  155. Pedley TJ. Mathematical modelling of arterial fluid dynamics. J Eng Math. 2003;3–4:419–444
  156. Phillips D, Parker KJ. A new imaging science test object for performance measurements of ultrasonic imaging systems. Phys Med Biol. 1998;43:455–465
  157. Philips DJ, Hossack J, Beach KW, Strandness DE. Testing ultrasonic pulsed Doppler instruments with a physiologic string phantom. J Ultrasound Med. 1990;9:426–436
  158. Picot PA, Embree PM. Quantitative volume flow estimation using velocity profiles. IEEE Trans Ultrason Ferroelectr Freq Cont. 1994;41:340–345
  159. Picot PA, Fruitman M, Rankin RN, Fenster A. Rapid volume flow-rate estimation using transverse color Doppler imaging. Ultrasound Med Biol. 1995;21:1199–1209
  160. Poepping TL, Nikolov HN, Rankin RN, Lee M, Holdsworth DW. An in vitro system for Doppler ultrasound flow studies in the stenosed carotid artery bifurcation. Ultrasound Med Biol. 2002;28:495–506
  161. Poepping TL, Nikolov HN, Thorne ML, Holdsworth DW. A thin-walled carotid vessel phantom for Doppler ultrasound flow studies. Ultrasound Med Biol. 2004;30:1067–1078
  162. Poots JK, Johnston KW, Cobbold RSC, Kassam M. Comparison of CW-Doppler ultrasound spectra with the spectra derived from a flow visualization model. Ultrasound Med Biol. 1986;12:125–133
  163. Ramnarine KV, Nassiri DK, Hoskins PR, Lubbers J. Validation of a new blood mimicking fluid for use in Doppler flow test objects. Ultrasound Med Biol. 1998;24:451–459
  164. Ramnarine KV, Hoskins PR, Davidson F. Doppler ultrasound properties of a new blood mimicking fluid. Ultrasound Med Biol. 1999;25:105–110
  165. Ramnarine KV, Anderson T, Hoskins PR. Construction and geometric stability of physiological flow rate wall-less stenosis phantoms. Ultrasound Med Biol. 2001;32:245–250
  166. Ressner M, Brodin LA, Jansson T, Hoff L, Ask P, Janerot-Sjoberg B. Effects of ultrasound contrast agents on Doppler tissue velocity estimation. J Am Soc Echocardiog. 2006;19:154–164
  167. Reuter R, Trier HG. The Doppler simulator DS 81, a new device for calibrating Doppler ultrasound equipment. Ultraschall. 1983;4:188–191
  168. Rickey DW, Rankin , Fenster A. A velocity evaluation phantom for colour flow and pulsed Doppler instruments. Ultrasound Med Biol. 1992;18:479–494
  169. Rickey DW, Picot PA, Christopher D, Fenster A. A wall-less vessel phantom for Doppler ultrasound studies. Ultrasound Med Biol. 1995;21:1163–1176
  170. Rickey DW, Fenster A. A Doppler ultrasound clutter phantom. Ultrasound Med Biol. 1996;22:747–766
  171. Rindt CC, Steenhoven AA. Unsteady flow in a rigid 3-D model of the carotid artery bifurcation. J Biomech Eng. 1996;118:90–96
  172. Rindt CCM, von Steenhoven AA, Reneman RS. An experimental-analysis of the flow field in a 3-dimensional model of the human carotid-artery bifurcation. J Biomech. 1998;21:985–991
  173. Rittgers SE, Fei DY. Flow dynamics in a stenosed carotid bifurcation model. 2 (Derived indexes). Ultrasound Med Biol. 1988;14:33–42
  174. Routh HF, Law YF, Mo LYL, Ojha M, Vaitkus PJ, Cobbold RSC, et al. Role of models in understanding and interpreting clinical Doppler ultrasound. Med Prog Technol. 1989;15:155–169
  175. Russell SV, McHugh D, Moreman BR. Programmable motion Doppler string test object. Phys Med Biol. 1993;38:1623–1630
  176. Ryan LK, Foster FS. Tissue equivalent phantoms for intravascular ultrasound. Ultrasound Med Biol. 1997;23:261–273
  177. Saffman PG. Lift on a small sphere in a slow shear flow. J Fluid Mech. 1965;22:385–400
  178. Schaar JA, de Korte CL, Mastik F, van Damme LCA, Krams R, Serruys PW, et al. Three-dimensional palpography of human coronary arteries—Ex vivo validation and in-patient evaluation. Herz. 2005;30:125–133
  179. Selfridge AR. Approximate material properties in isotropic materials. IEEE Trans Sonics Ultrason. 1985;32:381–394
  180. Sheldon CD, Duggan TC. Low cost Doppler signal simulator. Med Biol Eng Comput. 1987;25:226–228
  181. Sherwin SJ, Franke V, Peiro J, Parker K. One-dimensional modelling of a vascular network in space-time variables. J Eng Math. 2003;47:217–250
  182. Shortland AP, Cochrane T. Doppler spectral waveform generation in vitro: An aid to diagnosis of vascular disease. Ultrasound Med Biol. 1989;15:737–748
  183. Siggers JH, Waters SL. Steady flows in pipes with finite curvature. Phys Fluids. 2005;17, 077102 http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=PHFLE6000017000007077102000001&idtype=cvips&gifs=yes
  184. Slager CJ, Wentzel JK, Gijsen FJH, Schuurbiers JCH, van der Wal AC, van der Steen AFW, et al. The role of shear stress in the generation of rupture-prone vulnerable plaques. Nature Clin Pract Cardiovasc Med. 2005;2:401–407
  185. Slager CJ, Wentzel JJ, Gijsen FJH, Thury A, van der Wal AC, Schaar JA, et al. The role of shear stress in the destabilization of vulnerable plaques and related therapeutic implications. Nature Clin Pract Cardiovasc Med. 2005;2:456–464
  186. Smith RF, Rutt BK, Fox AJ, Rankin RN. Geometric characterization of stenosed human carotid arteries. Acad Radiol. 1996;3:898–911
  187. Smith RF, Rutt BK, Holdsworth DW. Anthropomorphic carotid bifurcation phantom for MRI applications. J Magn Res Imag. 1999;10:533–544
  188. Spencer T, Ramo MP, Salter DM, Anderson T, Kearney PP, Sutherland GR, et al. Characterisation of atherosclerotic plaque by spectral analysis of intravascular ultrasound: An in vitro methodology. Ultrasound Med Biol. 1997;23:191–203
  189. Steel R, Fish PJ. Lumen pressure within obliquely insonated absorbent solid cylindrical shells with application to Doppler flow phantoms. IEEE Trans Ultrason Ferroelectr Freq Control. 2002;49:271–280
  190. Steel R, Fish PJ. A simulation study of sample volume sensitivity for oblique pulsed finite beam insonation of Doppler ultrasound flow phantom cylindrical vessels. IEEE Trans Ultrason Ferroelectr Freq Control. 2003;50:58–67
  191. Steinman AH, Tavakkoli J, Myers JG, Cobbold RSC, Johnston KW. Sources of error in maximum velocity estimation using linear phased-array Doppler systems with steady flow. Ultrasound Med Biol. 2001;27:655–664
  192. Steinman DA, Vorp DA, Ethier CR. Computational modeling of arterial biomechanics: Insights into pathogenesis and treatment of vascular disease. J Vasc Surg. 2003;37:1118–1128
  193. Stewart SFC. A rotating torus phantom for assessing color Doppler accuracy. Ultrasound Med Biol. 1999;25:1251–1264
  194. Stewart SFC. Effects of transducer, velocity, Doppler angle, and instrument settings on the accuracy of color Doppler ultrasound. Ultrasound Med Biol. 2001;27:551–564
  195. Suhling M, Arigovindan M, Jansen C, Hunziker P, Unser M. Myocardial motion analysis from B-mode echocardiograms. IEEE Trans Imag Proc. 2005;14:525–536
  196. Surry KJM, Austin HJB, Fenster A, Peters TM. Poly(vinyl alcohol) cryogel phantoms for use in ultrasound and MR imaging. Phys Med Biol. 2004;49:5529–5546
  197. Taylor CA, Draney MT. Experimental and computational methods in cardiovascular fluid mechanics. Annu Rev Fluid Mech. 2004;36:197–231
  198. Teirlinck CJPM, Bezemer RA, Kollman C, Lubbers J, Hoskins PR, Fish P, et al. Development of an example flow test object and comparison of five of these test objects in various laboratories. Eur J Ultrasound. 1998;36:653–660
  199. Thompson RS, Aldis GK. Effect of a cylindrical refracting interface on ultrasound intensity and the CW Doppler spectrum. IEEE Trans Biomed Eng. 1996;43:451–459
  200. Thompson RS, Aldis GK. Flow spectra from spectral power density calculations for pulsed Doppler. Ultrasonics. 2002;40:835–841
  201. Thompson RS, Bambi G, Steel R, Tortoli P. Intraluminal ultrasound intensity distribution and backscattered Doppler power. Ultrasound Med Biol. 2004;30:1485–1494
  202. Thompson RS, Macaskill C, Fraser VB, Farnell L. Acoustic intensity for a long vessel with noncircular cross section. IEEE Trans Ultrason Ferroelectr Freq Control. 2004;51:566–575
  203. Thrush AJ, Evans DH. Intrinsic spectral broadening: a potential cause of misdiagnosis of carotid artery disease. J Vasc Invest. 1995;1:187–192
  204. Tropea C. Laser Doppler anemometry: recent developments and future challenges. Meas Sci Technol. 1995;6:605–619
  205. Ugolini P, Delouche A, Herment A, Diebold B. In vitro flow quantification with contrast power Doppler imaging. Ultrasound Med Biol. 2000;26:113–120
  206. Veltmann C, Lohmaier S, Schlosser T, Shai S, Ehlgen A, Pohl C, et al. On the design of a capillary flow phantom for the evaluation of ultrasound contrast agents at very low flow velocities. Ultrasound Med Biol. 2002;28:625–634
  207. Vennemann P, Lindken R, Westerweel J. In vivo whole-field blood velocity measurement techniques. Exp Fluids. 2007;42:495–511
  208. Wallace JJA, Martin K, Whittingham TA. An experimental single sideband acoustical re-injection test method for Doppler systems. Physiol Meas. 1993;14:479–484
  209. Walker AR, Philips DJ, Powers JE. Evaluating Doppler devices using a moving string test target. J Clin Ultrasound. 1982;10:25–30
  210. Walker A, Olsson E, Wranne B, Ringqvist I, Ask P. Accuracy of spectral Doppler flow and tissue velocity measurements in ultrasound systems. Ultrasound Med Biol. 2004;30:127–132
  211. Walker RD, Smith RE, Sherriff SB, Wood RFM. Latex vessels with customized compliance for use in arterial flow models. Phys Meas. 1999;20:277–286
  212. Walker RD, Sherriff SB, Wood RFM. The development of a model of the femoral artery bifurcation for use with duplex Doppler systems. Ultrasound Med Biol. 2003;29:487–494
  213. Wang KY, Bone SN, Hossack JM. A tool for evaluating Doppler sensitivity. J Vasc Technol. 1992;16:87–94
  214. Watson RJ, McLean CC, Moore MP, Spencer T, Salter DM, Anderson T, et al. Classification of arterial plaque by spectral analysis of in vitro radio frequency intravascular ultrasound data. Ultrasound Med Biol. 2000;6:73–80
  215. Watts DM, Sutcliffe CJ, Morgan RH, Ramnarine KV, Bastin M, Marshall I, et al. Anatomical flow phantoms of the nonplanar carotid bifurcation I (Design). Ultrasound Med Biol. 2007;33:296–302
  216. Weigand CJ, Liepsch DW. Color Doppler velocity measurements compared with laser Doppler anemometry under pulsatile flow conditions. Instrument Sci Technol. 1999;27:255–266
  217. Wendling F, Jones SA, Giddens DP. Simulation of Doppler ultrasound signals for a laminar, pulsatile, nonuniform flow. Ultrasound Med Biol. 1992;18:179–193
  218. Westerhof N, Sipkema P, Vandenbo GC, Elzinga G. Forward and backward waves in arterial system. Cardiovac Res. 1972;6:648–656
  219. Womersley JR. Method for the calculation of velocity, rate of flow and viscous drag in arteries when the pressure gradient is known. J Physiol London. 1955;127:553–563
  220. Wu SJ, Shung KK. Sensitivity measurement of ultrasonic Doppler instruments. Biomed Eng Appl Basis Commun. 1995;7:12–16
  221. Yuan YW, Shung KK. Ultrasonic backscatter from flowing whole-blood. 2 (Dependence on frequency and fibrinogen concentration). J Acoust Soc Am. 1988;84:1195–1200
  222. Zarins CK, Giddens DP, Bharadvaj BK, Sottiurai VS, Mabon RF, Glagov S. Carotid bifurcation atherosclerosis quantitative correlation of plaque localization with flow velocity profiles and wall shear-stress. Circ Res. 1983;53:502–514
  223. Zhang Y, Cardoso JC, Wang YY, Fish PJ, Bastos CAC. Time-scale removal of “Wall thump” in Doppler ultrasound signals: A simulation study. IEEE Trans Ultrason Ferroelectr Freq Control. 2004;51:1187–1192

PII: S0301-5629(07)00549-2

doi: 10.1016/j.ultrasmedbio.2007.10.017

Ultrasound in Medicine and Biology
Volume 34, Issue 5 , Pages 693-717 , May 2008