Ultrasound in Medicine and Biology
Volume 34, Issue 3 , Pages 406-413 , March 2008

Effective Tumor Treatment Using Optimized Ultrasound-Mediated Delivery of Bleomycin

  • John O. Larkin

      Affiliations

    • Cork Cancer Research Centre, Leslie C. Quick Laboratory, University College Cork, and Mercy University Hospital, Cork, Ireland
  • ,
  • Garrett D. Casey

      Affiliations

    • Cork Cancer Research Centre, Leslie C. Quick Laboratory, University College Cork, and Mercy University Hospital, Cork, Ireland
  • ,
  • Mark Tangney

      Affiliations

    • Cork Cancer Research Centre, Leslie C. Quick Laboratory, University College Cork, and Mercy University Hospital, Cork, Ireland
  • ,
  • James Cashman

      Affiliations

    • Cork Cancer Research Centre, Leslie C. Quick Laboratory, University College Cork, and Mercy University Hospital, Cork, Ireland
  • ,
  • Chris G. Collins

      Affiliations

    • Cork Cancer Research Centre, Leslie C. Quick Laboratory, University College Cork, and Mercy University Hospital, Cork, Ireland
  • ,
  • Declan M. Soden

      Affiliations

    • Cork Cancer Research Centre, Leslie C. Quick Laboratory, University College Cork, and Mercy University Hospital, Cork, Ireland
  • ,
  • Gerald C. O’Sullivan

      Affiliations

    • Cork Cancer Research Centre, Leslie C. Quick Laboratory, University College Cork, and Mercy University Hospital, Cork, Ireland
    • Department of Surgery, Mercy University Hospital, Cork, Ireland
    • Corresponding Author InformationAddress correspondence to: Prof. Gerald C. O’Sullivan, Cork Cancer Research Centre, Mercy University Hospital, Grenville Place, Cork, Ireland.

Received 2 May 2007 ,Revised 20 August 2007 ,Accepted 5 September 2007.

References 

  1. Belehradek M, Domenge C, Luboinski B, Orlowski S, Belehradek J, Mir LM. Electrochemotherapy, a new antitumor treatment (First clinical phase I-II trial). Cancer. 1993;72:3694–3700
  2. Coleman AJ, Saunders JE. A review of the physical properties and biological effects of the high amplitude acoustic field used in extracorporeal lithotripsy. Ultrasonics. 1993;31:75–89
  3. Gehl J, Skovsgaard T, Mir LM. Enhancement of cytotoxicity by electropermeabilization: An improved method for screening drugs. Anticancer Drugs. 1998;9:319–325
  4. Gehl J, Geertsen PF. Efficient palliation of haemorrhaging malignant melanoma skin metastases by electrochemotherapy. Melanoma Res. 2000;10:585–589
  5. Gothelf A, Mir LM, Gehl J. Electrochemotherapy: Results of cancer treatment using enhanced delivery of bleomycin by electroporation. Cancer Treat Rev. 2003;29:371–387
  6. Heller R, Jaroszeski MJ, Reintgen DS, Puleo CA, DeConti RC, Gilbert RA, et al. Treatment of cutaneous and subcutaneous tumors with electrochemotherapy using intralesional bleomycin. Cancer. 1998;83:148–157
  7. Ingram M, Arregui ME. Endoscopic ultrasonography. Surg Clin North Am. 2004;84:1035–1059
  8. Langer R. New methods of drug delivery. Science. 1990;249:1527–1533
  9. Larkin JO, Collins CG, Aarons S, Tangney M, Whelan M, O’Reily S, et al. Electrochemotherapy: Aspects of preclinical development and early clinical experience. Ann Surg. 2007;245:469–479
  10. Jaroszeski MJ, Dang V, Pottinger C, Hickey J, Gilbert R, Heller R. Toxicity of anticancer agents mediated by electroporation in vitro. Anticancer Drugs. 2000;11:201–208
  11. Mir LM, Banoun H, Paoletti C. Introduction of definite amounts of nonpermeant molecules into living cells after electropermeabilization: Direct access to the cytosol. Exp Cell Res. 1988;175:15–25
  12. Mir LM, Orlowski S, Belehradek J, Paoletti C. Electrochemotherapy potentiation of antitumour effect of bleomycin by local electric pulses. Eur J Cancer. 1991;27:68–72
  13. Mir LM, Tounekti O, Orlowski S. Bleomycin: Revival of an old drug. Gen Pharmacol. 1996;27:745–748
  14. Mir LM, Orlowski S. Mechanisms of electrochemotherapy. Adv Drug Deliv Rev. 1999;35:107–118
  15. Mir LM. Electrochemotherapy. Eur J Cancer Suppl. 2006;4:1–60
  16. Sersa G, Cemazar M, Miklavcic D. Antitumour effectiveness of electrochemotherapy with cis-diamminedichloroplatinum(II) in mice. Cancer Res. 1995;55:3450–3455
  17. Soden DM, Larkin JO, Collins CG, Tangney M, Aarons S, Piggott J, et al. Successful application of targeted electrochemotherapy using novel flexible electrodes and low dose bleomycin to solid tumours. Cancer Lett. 2006;232:300–310
  18. Tachibana K, Uchida T, Ogawa K, Yamashita N, Tamura K. Induction of cell-membrane porosity by ultrasound. Lancet. 1999;353:1409
  19. Tachibana K, Uchida T, Tamura K, Eguchi H, Yamashita N, Ogawa K. Enhanced cytotoxic effect of Ara-C by low intensity ultrasound to HL-60 cells. Cancer Lett. 2000;149:189–194
  20. Tomizawa M, Ebara M, Saisho H, Sakiyama S, Tagawa M. Irradiation with ultrasound of low output intensity increased chemosensitivity of subcutaneous solid tumors to an anti-cancer agent. Cancer Lett. 2001;173:31–35
  21. Uchida T, Sanghvi NT, Gardner TA, Koch MO, Ishii D, Minei S, et al. Transrectal high-intensity focused ultrasound for treatment of patients with stage T1b-2n0m0 localized prostate cancer: A preliminary report. Urology. 2002;59:394–398discussion 398–399
  22. Wu F, Wang ZB, Chen WZ, Wang W, Gui Y, Zhang M, et al. Extracorporeal high intensity focused ultrasound ablation in the treatment of 1038 patients with solid carcinomas in China: An overview. Ultrason Sonochem. 2004;11:149–154
  23. Wu F, Wang ZB, Chen WZ, Zhu H, Bai J, Zou JZ, et al. Extracorporeal high intensity focused ultrasound ablation in the treatment of patients with large hepatocellular carcinoma. Ann Surg Oncol. 2004;11:1061–1069
  24. Wu F, Wang ZB, Chen WZ, Zou JZ, Bai J, Zhu H, et al. Extracorporeal focused ultrasound surgery for treatment of human solid carcinomas: Early Chinese clinical experience. Ultrasound Med Biol. 2004;30:245–260
  25. Yu T, Wang Z, Jiang S. Potentiation of cytotoxicity of adriamycin on human ovarian carcinoma cell line 3AO by low-level ultrasound. Ultrasonics. 2001;39:307–309

PII: S0301-5629(07)00465-6

doi: 10.1016/j.ultrasmedbio.2007.09.005

Ultrasound in Medicine and Biology
Volume 34, Issue 3 , Pages 406-413 , March 2008