Ultrasound in Medicine and Biology
Volume 33, Issue 11 , Pages 1736-1749 , November 2007

Comparison of Contrast Enhanced Ultrasound and Contrast Enhanced CT or MRI in Monitoring Percutaneous Thermal Ablation Procedure in Patients with Hepatocellular Carcinoma: A Multi-Center Study in China

  • Ming-de Lu

      Affiliations

    • The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
    • Corresponding Author InformationAddress correspondence to: Ming-de Lu, MD, The First Affiliated Hospital of Sun Yat-sen University, No. 58, Zhong Shan Road 2, Guangzhou, China.
    • ,
  • Xiao-ling Yu

      Affiliations

    • General Hospital of PLA, Beijing, China
    • ,
  • An-hua Li

      Affiliations

    • Sun Yat-sen University Cancer Center, Guangzhou, China
    • ,
  • Tian-an Jiang

      Affiliations

    • The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    • ,
  • Min-hua Chen

      Affiliations

    • School of Oncology, Peking University, Beijing, China
    • ,
  • Bao-zhen Zhao

      Affiliations

    • Changhai Hospital, The Second Military Medical University, Shanghai, China
    • ,
  • Xiao-dong Zhou

      Affiliations

    • Xijing Hospital, The Fourth Military Medical University, Xi’an, China
    • ,
  • Jin-rui Wang

      Affiliations

    • Peking University Third Hospital, Beijing, China

Received 24 January 2007 ,Revised 20 March 2007 ,Accepted 1 May 2007.

References 

  1. Albrecht T, Blomley M, Bolondi L, Claudon M, Correas J-M, Cosgrove D, et al. Guidelines for the use of contrast agents in ultrasound: January 2004. Ultraschall Med. 2004;25(4):249–256
  2. Beppu T, Ogawa M, Matsuda T, Ohara C, Hirota M, Shimada S, et al. Efficacy of microwave coagulation therapy (MCT) in patients with liver tumors. Gan To Kagaku Ryoho. 1998;25:1358–1361
  3. Buscarini L, Buscarini E, Di Stasi M, Vallisa D, Quaretti P, Rocca A. Percutaneous radio-frequency ablation of small hepatocellular carcinoma: Long-term results. Eur Radiol. 2001;11:914–921
  4. Chen MH, Yang Wei, Yan Kun, Zou MW, Solbiati L, Liu JB, et al. Large Liver Tumor: Protocol for radio-frequency ablation and its clinical application in 110 patients (Mathematic model, overlapping mode, and electrode placement process). Radiology. 2004;232:260–271
  5. Choi D, Lim HK, Kim SH, Lee WJ, Jang HJ, Lee JY, et al. Hepatocellular carcinoma treated with percutaneous radio-frequency ablation: Usefulness of power Doppler US with a microbubble contrast agent in evaluating therapeutic response (Preliminary results). Radiology. 2000;217:558–563
  6. Choi D, Lim HK, Lee WJ, Kim SH, Kim YH, Kim SH, et al. Early assessment of the therapeutic response to radio-frequency ablation for hepatocellular carcinoma utility of gray-scale harmonic ultrasonography with a microbubble contrast agent. J Ultrasound Med. 2003;22:1163–1172
  7. Dietrich CF, Kratzer W, Strobe D, Danse E, Fessl R, Bunk A, et al. Assessment of metastatic liver disease in patients with primary extra hepatic tumors by contrast-enhanced sonography versus CT and MRI. World J Gastroenterol. 2006;21:12(11):1699–1705
  8. Dodd GD, Soulen M, Kane R, Livraghi T, Lees WR, Yamashita Y, et al. Minimally invasive treatment of malignant hepatic tumor: At the threshold of major breakthrough. Radiographics. 2000;20:9–27
  9. Dong BW, Liang P, Yu XL, Li Su, Dejiang Yu, Zhigang Cheng, et al. Percutaneous sonographically guided microwave coagulation therapy for hepatocellular carcinoma: Results in 234 patients. Am J Roentgenol. 2003;180:1547–1555
  10. Dromain C, de Baere T, Elias D, Kuoch V, Ducreux M, Boige V, et al. Hepatic tumor treated with percutaneous radio-frequency ablation: CT and MR imaging follow-up. Radiology. 2002;223:255–262
  11. Fiore F, Vallone P, Ricchi R, Tambaro R, Daniele B, Sandomenico F, et al. Levovist-enhanced Doppler sonography to evaluate response to percutaneous ethanol injection in hepatocellular carcinoma. J Clin Gastroenterol. 2000;31:164–168
  12. Gazelle GS, Goldberg SN, Solbiati L, Livraghi T. Tumor ablation with radio-frequency energy. Radiology. 2000;217:633–646
  13. Giorgio A, Ferraioli G, Tarantino L, de Stefano G, Scala V, Scarano F, et al. Contrast-enhanced sonographic appearance of hepatocellular carcinoma in patients with cirrhosis: Comparison with contrast-enhanced helical CT appearance. Am J Roentgenol. 2004;183(5):1319–1326
  14. Goldberg SN, Gazelle GS, Solbiati L, Livraghi T, Tanabe KK, Hahn PF, et al. Ablation of liver tumors using percutaneous RF therapy. Am J Roentgenol. 1998;170:1023–1028
  15. Goldberg SN, Walovitch RC, Straub JA, Shore MT, Gazelle GS. Radio-frequency-induced coagulation necrosis in rabbits: Immediate detection at US with a synthetic microsphere contrast agent. Radiology. 1999;213:438–444
  16. Goldberg SN, Gazelle GS, Compton CC, Mueller PR, Tanabe KK. Treatment of intrahepatic malignancy with radio-frequency ablation: Radiologic-pathologic correlation. Cancer. 2000;88:2452–2463
  17. Goldberg S, Ahmed M. Minimally invasive image-guided therapies for hepatocellular carcinoma. J Clin Gastroenterol. 2002;35:S115–S129
  18. Goldberg S, Grassi C, Cardella J, Charboneau JW, Dodd GD, Dupuy DE, et al. Image-guided tumor ablation: Standardization of terminology and reporting criteria. Radiology. 2005;235:728–739
  19. Hohmann J, Skrok J, Puls R, Albrecht T. Charakterisierung fokaler leberlasionen mit kontrastmittelgestutztem “low MI real-time” ultraschall und SonoVue (Characterization of focal liver lesions with contrast-enhanced low MI real-time ultrasound and SonoVue). Rofo. 2003;175(6):835–843
  20. Ikeda M, Okada S, Ueno H, Okusaka T, Kuriyama H. Radio-frequency ablation and percutaneous ethanol injection in patients with small hepatocellular carcinoma: A comparative study. Jpn J Clin Oncol. 2001;31:322–326
  21. Kim AY, Choi BI, Kim TK, Han JK, Yun EJ, Lee KY, et al. Hepatocellular carcinoma: Power Doppler US with a contrast agent—preliminary results. Radiology. 1998;209:135–140
  22. Kim SK, Lim HK, Kim YH, Lee WJ, Lee SJ, Kim SH, et al. Hepatocellular carcinoma treated with radio-frequency ablation: Spectrum of imaging findings. Radiographics. 2003;23:107–121
  23. Kim CK, Choi D, Lim HK, Kim SH, Lee WJ, Kim MJ, et al. Therapeutic response assessment of percutaneous radio-frequency ablation for hepatocellular carcinoma: Utility of contrast-enhanced agent detection imaging. Eur J Radiol. 2005;56(1):66–73
  24. Krix M, Plathow C, Essig M, Herfarth K, Debus J, Kauczor H-U, et al. Title Monitoring of liver metastases after stereotactic radiotherapy using low-mi contrast-enhanced ultrasound—initial results. Eur Radiol. 2005;15(4):677–684
  25. Lau WY, Leung TW, Yu SC, Ho SK. Percutaneous local ablative therapy for hepatocellular carcinoma: A review and look into the future. Ann Surg. 2003;237:171–179
  26. Lencioni R, Cioni D, Crocetti L, Donati F, Franchini C, Giusti S, et al. Ultrasound imaging of focal liver lesions with a second-generation contrast agent. Acad Radiol. 2002;9(Suppl 2):S371–S374
  27. Lencioni R, Allgaier HP, Cioni D, Olschewski M, Deibert P, Crocetti L, et al. Small hepatocellular carcinoma in cirrhosis: Randomized comparison of radio-frequency thermal ablation versus percutaneous ethanol injection. Radiology. 2003;228:235–240
  28. Li R, Guo Y, Hua X, He Y, Ding J, Guo A, et al. Characterization of focal liver lesions: Comparison of pulse-inversion harmonic contrast-enhanced sonography with contrast-enhanced CT. J Clin Ultrasound. 2007;35:109–117
  29. Lim HK, Choi D, Lee WJ, Kim SH, Lee SJ, Jang HJ, et al. Hepatocellular carcinoma treated with percutaneous radio-frequency ablation: Evaluation with follow-up multiphase helical CT. Radiology. 2001;221:447–454
  30. Lim HK, Han JK. Hepatocellular carcinoma: Evaluation of therapeutic response to interventional procedures. Abdom Imaging. 2002;27:168–179
  31. Livraghi T, Goldberg S, Lazzaroni S, Meloni F, Solbiati L, Gazelle GS. Small hepatocellular carcinoma: Treatment with radio-frequency ablation versus ethanol injection. Radiology. 1999;210:655–661
  32. Livraghi T, Lazzaroni S, Meloni F. Radio-frequency thermal ablation of hepatocellular carcinoma. Eur J Ultrasound. 2001;13:159–166
  33. Lu MD, Chen JW, Xie XY. Hepatocellular carcinoma: US guided percutaneous microwave coagulation therapy. Radiology. 2001;221:167–172
  34. Lu MD, Xu HX, Xie XY, Yin XY, Chen JW, Kuang M, et al. Percutaneous microwave and radio-frequency ablation for hepatocellular carcinoma: A retrospective comparison study. J Gastroenterol. 2005;40:1054–1060
  35. Meloni MF, Goldberg SN, Livraghi T, Calliada F, Ricci P, Rossi M, et al. Hepatocellular carcinoma treated with radio-frequency ablation: Comparison of pulse inversion contrast-enhanced harmonic sonography, contrast-enhanced power Doppler sonography, and helical CT. Am J Roentgenol. 2001;177:375–380
  36. Meloni MF, Livraghi T, Filice C, Lazzaroni S, Calliada F, Perretti L. Radio-frequency ablation of liver tumors: The role of microbubble ultrasound contrast agents. Ultrasound Q. 2006;22(1):41–47
  37. Numata K, Tanaka K, Kiba T, Saito S, Ikeda M, Hara K, et al. Contrast-enhanced, wide-band harmonic gray scale imaging of hepatocellular carcinoma correlation with helical computed tomography findings. J Ultrasound Med. 2001;20:89–98
  38. Pompili M, Riccardi L, Covino M, Barbaro B, Di Stasi C, Orefice R, et al. Contrast-enhanced gray-scale harmonic ultrasound in the efficacy assessment of ablation treatments for hepatocellular carcinoma. Liver Int. 2005;25:954–961
  39. Poon RTP, Fan ST, Tsang FHF, Wong J. Loco regional therapies for hepatocellular carcinoma: A critical review from the surgeon’s perspective. Ann Surg. 2002;235:466–486
  40. Quaia E, Calliada F, Bertolotto M, Rossi S, Garioni L, Rosa L, et al. Characterization of focal liver lesions with contrast-specific US modes and a sulfur hexafluoride-filled microbubble contrast agent: Diagnostic performance and confidence. Radiology. 2004;232(2):420–430
  41. Schneider M, Arditi M, Barrau MB, Brochot J, Broillet A, Ventrone R, et al. BR1: A new ultrasonographic contrast agent based on sulfur hexafluoride-filled microbubbles. Invest Radiol. 1995;30(8):451–457
  42. Sironi S, Livraghi T, Meloni F, De Cobelli F, Ferrero C, Del Maschio A. Small hepatocellular carcinoma treated with percutaneous RF ablation: MR imaging follow-up. Am J Roentgenol. 1999;173:1225–1229
  43. Solbiati L, Goldberg SN, Ierace T, Dellanoce M, Livraghi T, Gazelle GS. Radio-frequency ablation of hepatic metastases: Postprocedural assessment with a US microbubble contrast agent (Early experience). Radiology. 1999;211:643–649
  44. Solbiati L, Tonolini M, Cova L, Goldberg SN. The role of contrast-enhanced ultrasound in the detection of focal liver lesions. Eur Radiol. 2001;11(Suppl 3):E15–E26
  45. Solbiati L, Tonolini M, Cova L. Monitoring RF Ablation. Eur Radiol. 2004;(Suppl 8):P34–P42
  46. Solbiati L, Ierace T, Tonolini M, Cova L. Guidance and monitoring of radio-frequency liver tumor ablation with contrast-enhanced ultrasound. Eur J Radiol. 2004;51(Suppl):S19–S23
  47. Varela M, Vilana R, Bianchi L, Garcia MA, Nicolau C, Sanchez M, et al. Usefulness of SonoVue microbubble-enhanced ultrasonography in the assessment of the efficacy of percutaneous ablation in patients with hepatocellular carcinoma. J Hepatol. 2004;40(Suppl 1):85
  48. Vilana R, Bianchi L, Nicolau C. Ecografia con contraste de segunda generacion (Sonovue(R)) en la valoracion del tratamiento percutaneo del carcinoma hepatocellular comparacion con la TC multifasica (Second-generation ultrasound contrast agents (Sonovue(R)) in the evaluation of percutaneous treatment of hepatocellular carcinoma: Comparison with multiphase CT). Radiologia. 2005;47(2):79–85
  49. Xu HX, Xie XY, Lu MD, Chen JW, Yin XY, Xu ZF, et al. Ultrasound-guided percutaneous thermal ablation of hepatocellular carcinoma using microwave and radio-frequency ablation. Clin Radiol. 2004;59:52–60
  50. Zhao-You Tang. Hepatocellular carcinoma-cause, treatment and metastasis. World J Gastroenterol. 2006;7:445–454

PII: S0301-5629(07)00248-7

doi: 10.1016/j.ultrasmedbio.2007.05.004

Ultrasound in Medicine and Biology
Volume 33, Issue 11 , Pages 1736-1749 , November 2007

Article Tools

* Image Usage & Resolution