Ultrasound in Medicine and Biology
Volume 33, Issue 8 , Pages 1171-1178 , August 2007

Calcium Distribution in the Vessel Wall and Intima-Media Thickness of the Human Carotid Arteries

  • Mária Tünde Magyar

      Affiliations

    • Department of Neurology, University of Debrecen, Debrecen, Hungary
    • Corresponding Author InformationAddress correspondence to: Mária Tünde Magyar, M.D., Ph.D, Department of Neurology, Medical and Health Science Center, University of Debrecen, Nagyerdei krt. 98., Debrecen, H-4012, Hungary.
    • ,
  • Zita Szikszai

      Affiliations

    • Institute of Nuclear Research of the Hungarian Academy of Sciences, Debrecen, Hungary
    • ,
  • Zsófia Kertész

      Affiliations

    • Institute of Nuclear Research of the Hungarian Academy of Sciences, Debrecen, Hungary
    • ,
  • Sándor Molnár

      Affiliations

    • Department of Neurology, University of Debrecen, Debrecen, Hungary
    • ,
  • Imre Uzonyi

      Affiliations

    • Institute of Nuclear Research of the Hungarian Academy of Sciences, Debrecen, Hungary
    • ,
  • Gusztáv Áron Szíki

      Affiliations

    • Institute of Nuclear Research of the Hungarian Academy of Sciences, Debrecen, Hungary
    • ,
  • László Csiba

      Affiliations

    • Department of Neurology, University of Debrecen, Debrecen, Hungary

Received 27 July 2006 ,Revised 24 January 2007 ,Accepted 31 January 2007.

References 

  1. Allison MA, Tiefenbrun J, Langer RD, Wright CM. Atherosclerotic calcification and intimal medial thickness of the carotid arteries. Int J Cardiol. 2005;103:98–104
  2. Barnett HJ, Taylor DW, Eliasziw M, et al. North American Symptomatic Carotid Endarterectomy Trial Collaborators Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. N Engl J Med. 1998;339:1415–1425
  3. Boer OJ, van der Wal AC, Becker AE. Atherosclerosis, inflammation, and infection. J Pathol. 2000;190(3):237–243
  4. Brands PJM, van de Poll SWE, Quaedackers JA, et al. Combined micro-PIXE and NIR Raman spectroscopic plaque characterisation in a human atherosclerotic aorta sample. Nucl Instr Meth B. 2001;181:454–459
  5. Davis PH, Dawson JD, Riley WA, Lauer RM. Carotid intima-medial thickness is related to cardiovascular risk factors measured from childhood through middle age: The Muscatine study. Circulation. 2001;104:2815–2819
  6. Demer LL. A skeleton in the atherosclerosis closet. Circulation. 1995;92:2029–2032
  7. Demer LL, Tintut Y. Osteopontin (Between a rock and a hard plaque). Circ Res. 1999;84:250–252
  8. Deneke T, Langner K, Grewe PH, Harrer E, Muller KM. Ossification in atherosclerotic carotid arteries. Z Kardiol. 2001;90(Suppl 3):106–115
  9. Epstein FH. Cardiovascular disease epidemiology: A journey from the past into the future. Circulation. 1996;93:1755–1764
  10. European Carotid Surgery Trialists’ Collaborative Group. MRC European carotid surgery trial: Interim results for symptomatic patients with severe (70–99%) stenosis or with mild (0–29%) stenosis. Lancet. 1991;337:1235–1243
  11. Faxon DP, Fuster V, Libby P, et al. Atherosclerotic Vascular Disease Conference: Writing Group III: Pathophysiology. Circulation. 2004;109:2617–2625
  12. Halliday A, Mansfield A, Marro J, et al. MRC Asymptomatic Carotid Surgery Trial (ACST) Collaborative Group Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: Randomised controlled trial. Lancet. 2004;363:1491–1502
  13. Howard G, Sharrett AR, Heiss G, et al. Carotid artery intima-medial thickness distribution in general populations as evaluated by B-mode ultrasound. Stroke. 1993;24:1297–1304
  14. Kanters SD, Algra A, van Leeuwen MS, et al. Reproducibility of in vivo carotid intima-media thickness measurements. Stroke. 1997;28:665–671
  15. LeGeros RZ. Formation and transformation of calcium phosphates: relevance to vascular calcification. Z Kardiol. 2001;90(Suppl 3):116–124
  16. Libby P. Changing concepts of atherogenesis. J Intern Med. 2000;247(3):349–358
  17. Lorenz MW, von Kegler S, Steinmetz H, Markus HS, Sitzer M. Carotid intima-media thickening indicates a higher vascular risk across a wide age range: Prospective data from the Carotid Atherosclerosis Progression Study (CAPS). Stroke. 2006;37:87–92
  18. Miralles M, Merino J, Busto M, et al. Quantification and characterization of carotid calcium with multi-detector CT-angiography. Eur J Vasc Endovasc Surg. 2006;32:561–567
  19. Murray CJ, Lopez AD. Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. Lancet. 1997;349:1436–1442
  20. Nandalur KR, Baskurt E, Hagspiel KD, Phillips CD, Kramer CM. Calcified carotid atherosclerotic plaque is associated less with ischemic symptoms than is noncalcified plaque on MDCT. AJR Am J Roentgenol. 2005;184:295–298
  21. Nandalur KR, Baskurt E, Hagspiel KD, et al. Carotid artery calcification on CT may independently predict stroke risk. Am J Roentgenol. 2006;186:547–552
  22. Newby AC, Zaltsman AB. Molecular mechanisms in intimal hyperplasia. J Pathol. 2000;190(3):300–309
  23. Nicolaides AN, Kakkos SK, Griffin M, et al. Asymptomatic Carotid Stenosis and Risk of Stroke (ACSRS) Study Group Effect of image normalization on carotid plaque classification and the risk of ipsilateral hemispheric ischemic events: Results from the asymptomatic carotid stenosis and risk of stroke study. Vascular. 2005;13:211–221
  24. Nicoletti A, Caligiuri G, Hansson GK. Immunomodulation of atherosclerosis: Myth and reality. J Intern Med. 2000;247(3):397–405
  25. Nogueira GV, Silveira L, Martin AA, et al. Raman spectroscopy study of atherosclerosis in human carotid artery. J Biomed Opt. 2005;10:031117
  26. Parhami F, Tintut Y, Patel JK, et al. Regulation of vascular calcification in atherosclerosis. Z Kardiol. 2001;90(Suppl 3):27–30
  27. Rajta I, Borbély-Kiss I, Mórik G, et al. The new ATOMKI scanning proton microprobe. Nucl Instrum Meth B. 1996;109–110148–153
  28. Shaalan WE, Cheng H, Gewertz B, et al. Degree of carotid plaque calcification in relation to symptomatic outcome and plaque inflammation. J Vasc Surg. 2004;40:262–269
  29. Simon A, Gariepy J, Chironi G, Megnien JL, Levenson J. Intima-media thickness: A new tool for diagnosis and treatment of cardiovascular risk. J Hypertens. 2002;20:159–169
  30. Solberg LA, Eggen DA. Localization and sequence of development of atherosclerotic lesions in the carotid and vertebral arteries. Circulation. 1971;43:711–724
  31. Staub D, Meyerhans A, Bundi B, Schmid HP, Frauchiger B. Prediction of cardiovascular morbidity and mortality: Comparison of the internal carotid artery resistive index with the common carotid artery intima-media thickness. Stroke. 2006;37:800–805
  32. Szabó Gy, Borbély-Kiss I. PIXYKLM computer package for PIXE analyses. Nucl Instrum Meth B. 1993;75:123–126
  33. Tohno S, Tohno Y. Age-related differences in calcium accumulation in human arteries. Cell Mol Biol (Noisy-le-grand). 1998;44:1253–1263
  34. Touboul PJ, Labreuche J, Vicaut E, Amarenco P GENIC Investigators. Carotid intima-media thickness, plaques, and Framingham risk score as independent determinants of stroke risk. Stroke. 2005;36:1741–1745
  35. Tsivgoulis G, Vemmos K, Papamichael C, et al. Common carotid artery intima-media thickness and the risk of stroke recurrence. Stroke. 2006;37:1913–1916
  36. Uzonyi I, Rajta L, Bartha L, Kiss ÁZ, Nagy A. Realization of the simultaneous micro-PIXE analysis of heavy and light elements at a nuclear microprobe. Nucl Instrum Meth B. 2001;181:193–198
  37. Uzonyi I, Szabó GY. PIXEKLM-TPI—A software package for quantitative elemental imaging with nuclear microprobe. Nucl Instr Meth B. 2005;231:156–161
  38. Virchow R. Der atheromatose Prozess der Arterien. Wien Med Wochenschr. 1856;6:825–828
  39. Watt F, Rajendran R, Ren MQ, Tan BKH, Halliwell B. A nuclear microscopy study of trace elements Ca, Fe, Zn, and Cu in atherosclerosis. Nucl Instr Meth B. 2006;249:646–652
  40. Wick G, Perschinka H, Xu Q. Autoimmunity and atherosclerosis. Am Heart J. 1999;138(5 Pt 2):S444–S449
  41. Zureik M, Ducimetiere P, Touboul PJ, et al. Common carotid intima-media thickness predicts occurrence of carotid atherosclerotic plaques: Longitudinal results from the Aging Vascular Study (EVA) study. Arterioscler Thromb Vasc Biol. 2000;20:1622–1629

PII: S0301-5629(07)00084-1

doi: 10.1016/j.ultrasmedbio.2007.01.017

Ultrasound in Medicine and Biology
Volume 33, Issue 8 , Pages 1171-1178 , August 2007

Article Tools

* Image Usage & Resolution