Ultrasound in Medicine and Biology
Volume 33, Issue 7 , Pages 1029-1038 , July 2007

Measurement of the Reflectivity of the Intima-Medial Layer of the Common Carotid Artery Improves the Discriminatory Value of Intima-Medial Thickness Measurement as a Predictor of Risk of Atherosclerotic Disease

  • Stephen M. Ellis

      Affiliations

    • Department of Radiology, King’s College Hospital, Denmark Hill, London, UK
    • Current address: Department of Radiology, London Chest Hospital, Bonner Rd, London E29JX, United Kingdom.
    • ,
  • Rossi P. Naoumova

      Affiliations

    • MRC Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London, UK
    • ,
  • Clare K. Neuwirth

      Affiliations

    • MRC Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London, UK
    • ,
  • Robert Eckersley

      Affiliations

    • Department of Imaging, Hammersmith Hospital, Du Cane Road, London, UK
    • ,
  • David O. Cosgrove

      Affiliations

    • Department of Imaging, Hammersmith Hospital, Du Cane Road, London, UK
    • ,
  • Gilbert R. Thompson

      Affiliations

    • MRC Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London, UK
    • ,
  • Paul S. Sidhu

      Affiliations

    • Department of Radiology, King’s College Hospital, Denmark Hill, London, UK
    • Corresponding Author InformationAddress correspondence to: Paul S. Sidhu, Radiology, Denmark Hill, King’s College Hospital, London SE5 9RS, United Kingdom.

Received 1 March 2006 ,Revised 1 September 2006 ,Accepted 1 November 2006.

References 

  1. The ARIC Investigators. The Atherosclerosis Risk in Communities (ARIC) Study: Design and objectives. Am J Epidemiol. 1989;129:687–702
  2. Belcaro G, Barsotti A, Nicolaides AN. Ultrasonic biopsy: A non-invasive screening technique to evaluate the cardiovascular system and to follow-up the progression of arteriosclerosis. Vasa. 1991;20:40–50
  3. Belcaro G, Fisher C, Veller M, Renton S, Geroulakos G, Ravasmani G, et al. Screening asymptomatic subjects with subclinical arteriosclerotic lesions with arterial ultrasonic biopsy (The P.A.P. Study). Vasa. 1993;22:232–240
  4. Belcaro G, Laurora G, Cesarone MR, De Sanctis MT, Incandela L, Barsotti A. Progression of subclinical atherosclerosis in 6 years (Ultrasound evaluation of the average, combined femoral and carotid bifurcation intima-media thickness). Vasa. 1995;24:227–232
  5. Bland J, Skordalaki A, Emery JL. Early intimal lesions in the common carotid artery. Cardiovasc Res. 1986;20:863–868
  6. Bots ML, de Jong PTVM, Hofman A, Grobbee DE. Left, right, near or far wall common carotid intima-media thickness measurements: Associations with cardiovascular disease and lower extremity arterial atherosclerosis. J Clin Epidemiol. 1997;50:801–807
  7. Bots ML, Hofman A, Grobbee DE. Increased common carotid intima-media thickness (Adaptive response or a reflection of atherosclerosis? Findings from the Rotterdam). Stroke. 1997;28:2442–2447
  8. Burke GL, Evans GW, Riley WA, Sharrett AR, Howard G, Barnes RW, et al. Arterial wall thickness is associated with prevalent cardiovascular disease in middle-aged adults. Stroke. 1995;26:386–391
  9. del Sol AI, Moons KG, Hollander M, Hofman A, Koudstaal PJ, Grobbee DE, et al. Is carotid intima-media thickness useful in cardiovascular disease risk assessment? (The Rotterdam Study). Stroke. 2001;32:1532–1538
  10. El-Barghouty N, Geroulakos G, Nicolaides A, Androulakis A, Bahal V. Computer-assisted carotid plaque characterisation. Euro J Vasc Endovasc Surg. 1995;9:389–393
  11. Ellis SM, Sidhu PS. Granularity of the carotid artery intima-medial layer: Reproducibility of quantification by a computer-based program. Br J Radiol. 2000;73:595–600
  12. Forbat SM, Naoumova RP, Sidhu PS, Neuwirth CKY, MacMahon M, Thompson GR, et al. The effect of cholesterol reduction with fluvastatin on aortic compliance, coronary calcification and carotid intimal-medial thickness: A pilot study. J Cardiovasc Risk. 1998;5:1–10
  13. Fowkes FGR, Price JF, Leng GC. Targeting subclinical atherosclerosis. BMJ. 1998;316:1764
  14. Fried LP, Borhani NO, Enright P, Furberg CD, Gardin JM, Kronmal RA, et al. The Cardiovascular Health Study: Design of a study of coronary heart disease and stroke in older adults. Ann Epidemiol. 1991;1:263–276
  15. Furberg CD, Adams HP, Applegate WB, Byington RP, Espeland MA, Hartwell T, et al. Effect of lovastatin on early carotid atherosclerosis and cardiovascular events (Asmptomatic Carotid Artery Progression Study (ACAPS) Research Group). Circulation. 1994;90:1679–1687
  16. Geroulakos G, O’Gorman DJ, Kalodiki E, Sheridan DJ, Nicolaides AN. The carotid intima-media thickness as a marker of the presence of severe symptomatic coronary artery disease. Eur Heart J. 1994;15:781–785
  17. Glagov S, Bassiouny HS, Giddens DP, Zarins CK. Intimal thickening: morphogenesis, functional significance and detection. J Vasc Invest. 1995;1:2–14
  18. Hennerici M, Steinke W. Accuracy of high-resolution ultrasound imaging for quantitative assessment of early carotid atherosclerosis. Cerebrovasc Dis. 1994;4:109–113
  19. Hodis HN, Mack WJ, Barth JC. Carotid intimal-media thickness as a surrogate end point for coronary artery disease. Circulation. 1996;94:2311–2312
  20. Hodis HN, Mack WJ, LaBree L, Selzer RH, Liu CR, Liu CH, et al. Reduction in carotid arterial wall thickness using Lovastatin and dietary therapy. Ann Intern Med. 1996;124:548–556
  21. Howard G, Manolio TA, Burke GL, Wolfson SK, O’Leary DH. Does the association of risk factors and atherosclerosis change with age? (An analysis of the combined ARIC and CHS cohorts). Stroke. 1997;28:1693–1701
  22. Howard G, Sharrett AR, Heiss G, Evans GW, Chambless LE, Riley WA, et al. Carotid artery intimal-medial thickness distribution in general populations as evaluated by B-mode ultrasound. Stroke. 1993;24:1297–1304
  23. Howard G, Wagenknecht LE, Burke GL, Diez-Roux A, Evans GW, McGovern P, et al. Cigarette smoking and progression of atherosclerosis (The atherosclerosis risk in communities (ARIC) Study). JAMA. 1998;279:119–124
  24. James EM, Earnest F, Forbes GS, Reese DF, Houser ON, Folger WN. High resolution dynamic ultrasound of the carotid bifurcation: a prospective evaluation. Radiology. 1982;144:853–858
  25. Kanters SDJM, Algra A, van Leeuwen MS, Banga JD. Reproducibility of in vivo carotid intima-media thickness measurements (A review). Stroke. 1997;28:665–671
  26. Kuller LH, Shemanski L, Psaty BM, Borhani NO, Gardin JM, Haan MN, et al. Subclinical disease as an independent risk factor for cardiovascular disease. Circulation. 1995;92:720–726
  27. O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. N Engl J Med. 1999;340:14–22
  28. Pignoli P, Tremoli E, Poli A, Oreste P, Paoletti R. Intimal plus medial thickness of the arterial wall: A direct measurement with ultrasound imaging. Circulation. 1986;74:1399–1406
  29. Salonen R, Haapanen A, Salonen JT. Measurement of intima-media thickness of common carotid arteries with high-resolution B-mode ultrasonography: Inter- and intra-observer variability. Ultrasound Med Biol. 1991;17:225–230
  30. Salonen R, Salonen JT. Progression of carotid atherosclerosis and its determinants: A population-based ultrasonography study. Atherosclerosis. 1990;81:33–40
  31. Salonen R, Salonen JT. Carotid atherosclerosis in relation to systolic and diastolic blood pressure: Kuopio ischaemic heart disease risk factor study. Ann Med. 1991;23:23–27
  32. Salonen R, Seppanen K, Rauramaa R, Salonen JT. Prevalence of carotid atherosclerosis and serum cholesterol levels in Eastern Finland. Arteriosclerosis. 1988;8:788–792
  33. Sandrock M, Cheng DC, Schmitz D, Schmidt-Trucksass A. Quantification of the wall inhomogeneity in B-mode sonographic images of the carotid artery. J Ultrasound Med. 2002;21:1395–1404
  34. Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, MacFarlane PW, et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. N Engl J Med. 1995;333:1301–1307
  35. Sidhu PS, Desai SR. A simple and reproducible method of assessing intimal-medial thickness of the common carotid artery. Br J Radiol. 1997;70:85–89
  36. Sidhu PS, Naoumova RP, Maher VMG, MacSweeney JE, Neuwirth CKY, Hollyer JS, et al. The extracranial carotid artery in familial hypercholesterolaemia: Relationship of intimal-medial thickness and plaque morphology with plasma lipids and coronary heart disease. J Cardiovasc Risk. 1996;3:61–67
  37. Simon A, Levenson J. Could the identification of subclinical atherosclerosis offer an alternative to the mass drug treatment of hypercholesterolemia?. Atherosclerosis. 1994;105:245–249
  38. Stary HC. Lipid and macrophage accumulations in arteries of children and the development of atherosclerosis. Am J Clin Nutrit. 2002;72:1297S–1306S
  39. Stary HC, Chandler AB, Glagov S, Guyton JR, Insull W, Rosenfeld ME, et al. A definition of initial, fatty streak and intermediate lesions of atherosclerosis (A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, Americian Heart Association). Circulation. 1994;89:2462–2478
  40. Stevens J, Tyroler HA, Cai J, Paton CC, Folsom AR, Tell GS, et al. Body weight change and carotid artery wall thickness (The Atherosclerosis Risk in Communities (ARIC) Study). Am J Epidemiol. 1998;147:563–573
  41. Touboul PJ, Prati P, Scarabin PY, Adrai V, Thibout E, Ducimrtiere P. Use of monitoring software to improve the measurement of carotid wall thickness by B-mode imaging. J Hypertens. 1992;10:S37–S41
  42. Wagenknecht LE, D’Agostino HB, Savage PJ, O’Leary DH, Saad MF, Haffner SM. Duration of diabetes and carotid wall thickness (The Insulin Resistance Atherosclerosis Study (IRAS)). Stroke. 1997;28:999–1005
  43. Weigman A, de Groot E, Hutten BA, Rodenburg J, Gort J, Bakker HD, et al. Arterial intima-media thickness in children heterozygous for familial hypercholesterolaemia. Lancet. 2004;363:369–370
  44. Wendelhag I, Liang Q, Gustavsson T, Wikstrand J. A new automated computerized analyzing system simplifies readings and reduces the variability in ultrasound measurements of intima-media thickness. Stroke. 1997;28:2195–2200
  45. Willeit J, Kiechl S. Prevalence and risk factors of asymptomatic extracranial carotid artery atherosclerosis. Arterioscler Thromb. 1993;13:661–668
  46. Wong M, Edelstein J, Wollman J, Bond G. Ultrasonic-pathological comparison of the human arterial wall: Verification of intima-media thickness. Arterioscler Thromb. 1993;13:482–486

PII: S0301-5629(07)00077-4

doi: 10.1016/j.ultrasmedbio.2007.02.002

Ultrasound in Medicine and Biology
Volume 33, Issue 7 , Pages 1029-1038 , July 2007

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