Rapid 3D Imaging of Contrast Flow: Demonstration of a Dual Beam Technique

Abstract 

Perfusion imaging in a 3D volume using ultrasound contrast agent may improve vascular characterization compared with 2D imaging. Conventional 3D acquisition requires excessive scan time. A dual transducer technique using conventional systems has been introduced that allows 3D imaging of contrast dynamics with drastically reduced scan times (LeCarpentier et al. 2003). Two transducers are translated across a volume where the leading transducer effects contrast clearance and the following transducer images at desired contrast refill times. With 2D arrays that allow simultaneous clearance and imaging pulses, scan times could be further reduced and the need for two transducers eliminated. The dual transducer technique was demonstrated on a tube phantom, with observed contrast profiles matching those expected. Measured center velocities of (± std dev) 1.46 ± 0.21 and 2.25 ± 0.5 did not statistically differ from expected values of 1.75 and 2.50 (all mm/s), (p > 0.05). This technique is introduced for rapid acquisition of 3D contrast refill images. (E-mail: gllec@umich.edu)

Key Words: Contrast refill, Perfusion, Blood flow, Imaging, Vasculature, Angiogenesis