Feasibility of Contrast-Enhanced Sonography During Resection of Cerebral Tumours: Initial Results of a Prospective Study

Engelhardt, Martin; Hansen, Christian; Eyding, Jens; Wilkening, Wilko; Brenke, Christopher; Krogias, Christos; Scholz, Martin; Harders, Albrecht; Ermert, Helmut; Schmieder, Kirsten

doi:10.1016/j.ultrasmedbio.2006.10.007

« Previous Next »Ultrasound in Medicine and Biology
Volume 33, Issue 4 , Pages 571-575, April 2007

Feasibility of Contrast-Enhanced Sonography During Resection of Cerebral Tumours: Initial Results of a Prospective Study

Martin Engelhardt
- Department of Neurosurgery, Ruhr-University Bochum, Knappschaftskrankenhaus Bochum, Bochum, Germany
- Ruhr Center of Excellence for Medical Engineering (KMR), c/o Institute of High Frequency Engineering, Ruhr-University Bochum, Bochum, Germany
- Address correspondence to: Dr. M. Engelhardt, Department of Neurosurgery, Ruhr-University Bochum, Knappschaftskrankenhaus Bochum, In der Schornau 23-25, 44892 Bochum, Germany.
Christian Hansen
- Ruhr Center of Excellence for Medical Engineering (KMR), c/o Institute of High Frequency Engineering, Ruhr-University Bochum, Bochum, Germany
Jens Eyding
- Ruhr Center of Excellence for Medical Engineering (KMR), c/o Institute of High Frequency Engineering, Ruhr-University Bochum, Bochum, Germany
- Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany
Wilko Wilkening
- Ruhr Center of Excellence for Medical Engineering (KMR), c/o Institute of High Frequency Engineering, Ruhr-University Bochum, Bochum, Germany
Christopher Brenke
- Department of Neurosurgery, Ruhr-University Bochum, Knappschaftskrankenhaus Bochum, Bochum, Germany
Christos Krogias
- Ruhr Center of Excellence for Medical Engineering (KMR), c/o Institute of High Frequency Engineering, Ruhr-University Bochum, Bochum, Germany
- Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany
Martin Scholz
- Department of Neurosurgery, Ruhr-University Bochum, Knappschaftskrankenhaus Bochum, Bochum, Germany
Albrecht Harders
- Department of Neurosurgery, Ruhr-University Bochum, Knappschaftskrankenhaus Bochum, Bochum, Germany
Helmut Ermert
- Ruhr Center of Excellence for Medical Engineering (KMR), c/o Institute of High Frequency Engineering, Ruhr-University Bochum, Bochum, Germany
Kirsten Schmieder
- Department of Neurosurgery, Ruhr-University Bochum, Knappschaftskrankenhaus Bochum, Bochum, Germany

Received 27 June 2006; received in revised form 26 September 2006; accepted 10 October 2006. published online 09 March 2007.

Abstract

The aim of this study was to adapt the ultrasonographical techniques developed for brain perfusion imaging to an intraoperative setting for topographic diagnosis of cerebral tumours. During surgery, the patients underwent contrast-enhanced ultrasonography (phase inversion harmonic imaging, bolus kinetic, fitted model function). Endocavity curved array (6.5EC10, 6.5 MHz) was used intraoperatively. The ultrasound contrast agent SonoVue^® (Bracco) was administered IV as a bolus injection. Off-line, time-intensity curves as well as perfusion maps were calculated and parameters such as peak intensity were locally extracted to characterise perfusion. Seven patients with brain tumours of different histologic types were subjected to contrast-enhanced ultrasonography during surgery. Tissue differentiation with contrast agent was superior to conventional B-mode ultrasound imaging. Intraoperative contrast-enhanced ultrasonography enabled visualisation of cerebral tumours in high spatial resolution. (E-mail: martin.engelhardt@ruhr-uni-bochum.de)

Key Words: Neurosurgery, Intraoperative ultrasound, THI (tissue harmonic imaging), Contrast-enhanced sonography, SonoVue