Ultrasound in Medicine and Biology
Volume 33, Issue 2 , Pages 187-196 , February 2007

WFUMB safety symposium on echo-contrast agents: Nature and types of ultrasound contrast agents

  • Ayache Bouakaz

      Affiliations

    • Inserm U619, Tours, France
    • Corresponding Author InformationAddress correspondence to: Ayache Bouakaz, PhD, Inserm U619, B1A, CHU Bretonneau, 2 Boulevard Tonnellé, 37044 Cedex, Tours, France.
    • ,
  • Nico de Jong

      Affiliations

    • Biomedical Engineering, Erasmus Medical Center, Rotterdam, the Netherlands

References 

  1. Barnhart J, Levene H, Villapando E, et al. Characteristics of Albunex®: air-filled albumin microspheres for echocardiography contrast enhancement. Invest Radiol. 1990;25(Suppl. 1):S162–S164
  2. Bouakaz A, Versluis M, de Jong N. High-speed optical observations of contrast agent destruction. Ultrasound Med Biol. 2005;31:391–399
  3. Bouakaz A, Frinking PJ, de Jong N, Bom N. Noninvasive measurement of the hydrostatic pressure in a fluid-filled cavity based on the disappearance time of micrometer-sized free gas bubbles. Ultrasound Med Biol. 1999;25:1407–1415
  4. Bouakaz A, de Jong N, Cachard C, Jouini K. On the effect of lung filtering and cardiac pressure on the standard properties of ultrasound contrast agent. Ultrasonics. 1998;36:703–708
  5. de Jong N, Hoff L, Skotland T, Bom N. Absorption and scatter of encapsulated gas filled microspheres: Theoretical considerations and some measurements. Ultrasonics. 1992;30:95–103
  6. de Jong N, Ten Cate FJ, Lancee CT, Roelandt JR, Bom N. Principles and recent developments in ultrasound contrast agents. Ultrasonics. 1991;29:324–330
  7. Fisher NG, Leong-Poi H, Sakuma T, et al. Detection of coronary stenosis and myocardial viability using a singe iv bolus injection of BR14®. J Am Coll Cardiol. 2002;39:523–529
  8. Frinking J, de Jong N. Acoustic modeling of shell-encapsulated gas bubbles. Ultrasound Med Biol. 1998;24:523–533
  9. Goldberg BB, Liu JB, Forsberg F. Ultrasound contrast agents: A review. Ultrasound Med Biol. 1994;20:319–333
  10. Gorce J, Arditi M, Schneider M. Influence of bubble size distribution on the echogenicity of ultrasound contrast agents. Invest Radiol. 2000;35:661–671
  11. Gramiak R, Shah P. Echocardiography of the aortic root. Invest Radiol. 1968;3:356–366
  12. Hogg JC. Neutrophil kinetics and lung injury. Physiological Review. 1987;67:1249–1295
  13. Hoff L, Sontum PC, Hovem JM. Acoustic characterisation of Nycomeds NC100100 contrast agent. Presented at IEEE Ultrasonics Symposium, Sendai, Japan, 1998.
  14. Kabalnov A, Klein D, Pelura T, Schutt E, Weers J. Dissolution of multicomponent microbubbles in the bloodstream: 1. Theory. Ultrasound Med Biol. 1998;24:739–749
  15. Lindner J, Dayton P, Coggins M. Noninvasive imaging of inflammation by us detection of phagocytosed microbubbles. Circulation. 2000;102:531–538
  16. Meltzer RS, Serruys PW, McGhie J, Roelandt J. Pulmonary wedge injection yielding left sided echocardiographic contrast. Br Heart J. 1980;44:390–394
  17. Ophir J, Parker KJ. Contrast agents in diagnostic ultrasound. Ultrasound Med Biol. 1989;15:319–333
  18. Porter EA. Effect of blood and microbubble oxygen and nitrogen content on perfluorocarbon-filled dextrose albumin microbubble size and efficacy. J Am Soc Echocardiogr. 1995;11:421–425
  19. Porter TR, Xie F. Transient myocardial contrast after initial exposure to diagnostic ultrasound pressures with minute doses of intravenously injected microbubbles (Demonstration and potential mechanisms). Circulation. 1995;92:2391–2395
  20. Schlief R. Ultrasound contrast agents. Curr Opin Radiol. 1991;3:198–207
  21. Schlief R, Mahler M. Successful opacification of left heart chambers on echocardiographic examination after iv injection of a new saccharide based contrast agent. Echocardiography. 1990;7:61–64
  22. Schneider M, Arditi M, Barrau B, et al. BR1: A new ultrasonographic contrast agent based on sulfur hexafluoride-filled microbubbles. Invest Radiol. 1995;30:451–457
  23. Shapiro JS, Reisner SA, Lichtenberg GS, Meltzer RS. Intravenous contrast echocardiography with use of sonicated albumin in humans: Systolic disappearance of left ventricular contrast after transpulmonary transmission. J Am Coll Cardiol. 1990;7:603–1607
  24. Van Liew HD, Burkard ME. Bubbles in circulating blood: Stabilization and simulations of cyclic changes of size and content. J Appl Physiol. 1995;79:1379–1385
  25. Van Liew HD, Burkard ME. Relationship of oxygen content to PO2 for stabilized bubbles in the circulation: Theory. J Appl Physiol. 1996;81:500–508
  26. Walovitch R, Kwan O, Picard M. Initial safety and myocardial perfusion imaging results with AI-700®: A synthetic polymeric UCA. J Am Soc Echocardiogr. 2000;13:457

PII: S0301-5629(06)01736-4

doi: 10.1016/j.ultrasmedbio.2006.07.008

Ultrasound in Medicine and Biology
Volume 33, Issue 2 , Pages 187-196 , February 2007

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