Ultrasound in Medicine and Biology
Volume 28, Issue 4 , Pages 467-474 , April 2002

Elastic modulus measurements of human liver and correlation with pathology

  • Wen-Chun Yeh

      Affiliations

    • Departments of Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan
  • ,
  • Pai-Chi Li

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Pai-Chi Li, Department of Electrical Engineering, National Taiwan University, No.1, Sec. 4, Roosevelt Road, Taipei, Taiwan 106
    • Departments of Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan
  • ,
  • Yung-Ming Jeng

      Affiliations

    • Pathology, National Taiwan University Hospital, Taipei, Taiwan
  • ,
  • Hey-Chi Hsu

      Affiliations

    • Pathology, National Taiwan University Hospital, Taipei, Taiwan
  • ,
  • Po-Ling Kuo

      Affiliations

    • Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan
  • ,
  • Meng-Lin Li

      Affiliations

    • Departments of Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan
  • ,
  • Pei-Ming Yang

      Affiliations

    • Internal MedicineNational Taiwan University Hospital, Taipei, Taiwan
  • ,
  • Po Huang Lee

      Affiliations

    • Surgery, National Taiwan University Hospital, Taipei, Taiwan

Received 26 September 2001 ,Accepted 31 January 2002.

References 

  1. Aklonis JJ. In: Introduction to polymer viscoelasticity. 2nd ed.. New York: John Wiley & Sons; 1983;p. 7–9
  2. Céspedes I, Ophir J, Ponnekanti H, Maklad N. Elastography (Elasticity imaging using ultrasound with application to muscle and breast in vivo). Ultrason Imaging. 1993;15:73–88
  3. Chen EJ, Norvokovski J, Jenkins WK, O’Brien WD. Young’s modulus measurements of soft tissues with application to elasticity imaging. IEEE Trans Ultrason Ferroelect Freq Control. 1996;43(1):191–194
  4. Emelianov SY, Lubinski MA, Weitzel WF, et al.  Elasticity imaging for early detection of renal pathology. Ultrasound Med Biol. 1995;21(7):871–883
  5. Emelianov SY, Rubin JM, Lubinski MA, Skovoroda AR, O’Donnell M. Elastic imaging of liver (Is a hemangioma hard or soft). IEEE Ultrason Sympos. 1998;2:1749–1752
  6. Erkamp RQ, Emelianov SY, Skovoroda AR, Chen X, O’Donnell M. Measuring the elastic modulus of small tissue sample. Ultrason Imag. 1998;20(1):17–28
  7. Erkamp RQ, Wiggins P, Skovoroda AR, Emelianov SY, O’Donnell M. Exploiting strain-hardening of tissue to increase contrast in elasticity imaging. IEEE Ultrason Sympos. 2000;2:1833–1836
  8. Fung YC. In: Biomechanics (Mechanical properties of living tissues). New York: Springer-Verlag; 1993;p. 259–263
  9. Hoffmeister BK, Verdun ED, Wickline SA, Miller JG. Effect of collagen on the anisotropy of quasi-longitudinal mode ultrasonic velocity in fibrous soft tissues (A comparison of fixed tendon and fixed myocardium). J Acoustic Soc Am. 1994;96(4):1957–1964
  10. Knodell RG, Isaac KG, Black WC, et al.  Formation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology. 1981;1(5):431–435
  11. Krouskop TA, Wheeler TM, Kallel F, Garra BS, Hall T. Elastic moduli of breast and prostate tissue under compression. Ultrason Imaging. 1998;20:260–274
  12. Kuo PL, Li PC, Li ML. Elastic properties of tendon measured by two different approaches. Ultrasound Med Biol. 2001;27(9):1275–1284
  13. Liu Z, Bilston L. On the viscoelastic character of liver tissue (Experiments and modeling of the linear behavior). Biorheology. 2000;37(3):191–201
  14. Norusis MJ. SPSS® for Windows™ (Base system user’s guide, release 6.0). Chicago, IL: SPSS, Inc; 1993;
  15. O’Donnell M, Skovoroda AR, Shapo BM, Emelianov ST. Internal displacement and strain imaging using ultrasonic speckle tracking. IEEE Trans Ultrason Ferroelec Freq Control. 1994;41(3):314–325
  16. Ophir J, Kallel F, Varghese T, et al.  Elastography (A systems approach). Int J Imaging Syst Technol. 1997;8:89–103
  17. Poynard T, Bedossa P, Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups. Lancet. 1997;349:825–832
  18. Sarvazyan AP, Rudenko OV, Swanson SD, Fowlkes JB, Emelianov SY. Shear wave elasticity imaging (A new ultrasonic technology of medical diagnostics). Ultrasound Med Biol. 1998;24(9):1419–1435
  19. Skovoroda AR, Emelianov ST, Lubinski MA, et al.  Theoretical analysis and verification of ultrasound displacement and strain imaging. IEEE Trans Ultrason Ferroelec Freq Control. 1994;41(3):302–313
  20. Skovoroda AR, Emelianov ST, O’Donnell M. Tissue elasticity reconstruction based on ultrasonic displacement and strain images. IEEE Trans Ultrason Ferroelec Freq Control. 1995;42(4):747–765
  21. Tschoegl NW. In: The phenomenological theory of linear viscoelastic behavior (An introduction). New York: Springer-Verlag; 1989;p. 57–63
  22. Wang BC, Wang GR, Yan DH, Liu YP. An experimental study on biomechanical properties of hepatic tissue using a new measuring method. Biomed Mat Eng. 1992;2(3):133–138
  23. Yamashita Y, Kubota M. Ultrasonic characterization of tissue hardness in the in vivo human liver. IEEE Ultrason Symp. 1994;3:1449–1453
  24. Yamashita Y, Kubota M. Ultrasonic imaging of elasticity of soft tissue based on measurement of internal displacement and strain. IEEE Ultrason Symp. 1995;2:1207–1211
  25. Yang PM, Huang GT, Lin JT, et al.  Ultrasonography in the diagnosis of benign diffuse parenchymal liver disease (A prospective study). J Formosan Med Assoc. 1988;187(10):966–977

PII: S0301-5629(02)00489-1

Ultrasound in Medicine and Biology
Volume 28, Issue 4 , Pages 467-474 , April 2002