Ultrasound in Medicine and Biology
Volume 28, Issue 4 , Pages 431-437 , April 2002

In vivo quantitation of tumour vascularisation assessed by Doppler sonography in rat mammary tumours

  • Fabrice Denis

      Affiliations

    • Laboratoire Nutrition, Croissance et Cancer, UPRES-EA 2103, Université François-Rabelais, Tours, France
    • IFR Imagerie et Exploration Fonctionnelles, Université François-Rabelais, Tours, France
    • ,
  • Philippe Bougnoux

      Affiliations

    • Laboratoire Nutrition, Croissance et Cancer, UPRES-EA 2103, Université François-Rabelais, Tours, France
    • ,
  • Loı̈ de Poncheville

      Affiliations

    • Laboratoire Nutrition, Croissance et Cancer, UPRES-EA 2103, Université François-Rabelais, Tours, France
    • ,
  • Marie Prat

      Affiliations

    • Laboratoire Nutrition, Croissance et Cancer, UPRES-EA 2103, Université François-Rabelais, Tours, France
    • ,
  • Rodolphe Catroux

      Affiliations

    • Laboratoire Nutrition, Croissance et Cancer, UPRES-EA 2103, Université François-Rabelais, Tours, France
    • ,
  • François Tranquart

      Affiliations

    • Corresponding Author InformationAddress correspondence to: François Tranquart, M.D., Médecine Nucléaire in-vivo et Ultrasons, Centre Hospitalier Universitaire, 37044 Tours, France
    • IFR Imagerie et Exploration Fonctionnelles, Université François-Rabelais, Tours, France

Received 1 October 2001 ,Accepted 9 January 2002.

References 

  1. Delorme S, Peschke P, Zuna I, Van Kaick G. Sensitivity of colour Doppler sonography (An experimental approach). Ultrasound Med Biol. 1999;25(4):541–547
  2. Donnelly EF, Geng L, et al.  Quantified power Doppler US of tumor blood flow correlates with microscopic quantification of tumor blood vessels. Radiology. 2001;219:166–170
  3. Drevs J, Hofmann I, Hugenschmidt H, et al.  Effects of PTK787/ZK 222584, a specific inhibitor of vascular endothelial growth factor receptor tyrosine kinase, on primary tumour, metastasis, vessel density and blood flow in a murine renal cell carcinoma model. Cancer Res. 2000;60(17):4819–4824
  4. Ferrara KW, Merritt CRB, Burns PN, et al.  Evaluation of tumor angiogenesis with US:imaging, Doppler, and contrast agents. Acad Radiol. 2000;7(10):824–839
  5. Fleischer AC. Sonographic depiction of tumour vascularity and flow:from in vivo models to clinical applications. J Ultrasound Med. 2000;19(1):55–61
  6. Fleischer AC, Wojcicki WE, Donnely EF, et al.  Quantified colour Doppler sonography of tumour vascularity in an animal model. J Ultrasound Med. 1999;18(8):547–551
  7. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med. 1995;1:27–31
  8. Folkman J. Tumour angiogenesis. In:  Mendelsohn J,  Howley PM,  Israel MA,  Liotta LA editor. The molecular basis of cancer. Philadelphia, PA: W. B. Saunders; 1995;p. 206–232
  9. Foster FS, Burns PN, Simpson DH, et al.  Ultrasound for the visualization and quantitation of tumor microcirculation. Cancer Metastasis Rev. 2000;19(1–2):131–138
  10. Fox SB, Leek RD, Weekes MP, et al.  Quantitation and prognostic value of breast cancer angiogenesis (Comparison of microvessel density, Chalkley count, and computer image analysis). J Pathol. 1995;177(3):275–283
  11. Gee MS, Saunders HM, Lee JC, et al.  Doppler ultrasound imaging detects changes in tumor perfusion during antivascular therapy associated with vascular anatomic alterations. Cancer Res. 2001;61(7):2974–2982
  12. Geng L, Donnelly E, McMahon G, et al.  Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy. Cancer Res. 2001;61(6):2413–2419
  13. Hansen S, Grabau DA, Rose C, Bak M, Sorensen FB. Angiogenesis in breast cancer (A comparative study of the observer variability of methods for determining microvessel density). Lab Invest. 1998;78(12):1563–1573
  14. Hansen S, Grabau DA, Sorensen FB, et al.  The prognostic value of angiogenesis by Chalkley counting in a confirmatory study design on 836 breast cancer patients. Clin Can Res. 2000;6(1):139–146
  15. Hirai T, Ohishi H, Yamada R, et al.  Three dimensional power Doppler sonography of tumour vascularity. Radiat Med. 1998;16(5):353–357
  16. Kallman RF, DeNardo GL, Stasch MJ. Blood flow in irradiated mouse sarcoma as determined by the clearance of xenon-133. Cancer Res. 1972;32(3):483–490
  17. Kook SH, Park HW, Lee YR, et al.  Evaluation of solid breast lesions with power Doppler sonography. J Clin Ultrasound. 1999;27(5):231–237
  18. Lhuillery C, Bougnoux P, Groscolas R, Durand G. Time-course study of adipose tissue fatty acid composition during mammary tumour growth in rats with controlled fat intake. Nutr Cancer. 1995;24(3):299–309
  19. Li VW, Folkerth RD, Watanabe H, et al.  Microvessel count and cerebrospinal fluid basic fibroblast growth factor in children with brain tumours. Lancet. 1994;344(8915):82–86
  20. Meyerowitz CB, Fleischer AC, Pickens DR, et al.  Quantification of tumour vascularity and flow with amplitude colour Doppler sonography in an experimental model (Preliminary results). J Ultrasound Med. 1996;15(12):827–833
  21. Meyerowitz CB, Fleischer AC, Pickens DR, et al.  Erratum. J Ultrasound Med. 1997;16(3):218
  22. Nelson NJ. Inhibitors of angiogenesis enter phase III testing. J Natl Cancer Inst. 1998;90(13):960–963
  23. Park KS, Choi BI, Won HJ, et al.  Intratumoral vascularity of experimentally induced VX2 carcinoma:comparison of colour Doppler sonography, power Doppler sonography, and microangiography. Invest Radiol. 1998;33(1):39–44
  24. Weidner N. Angiogenesis as a predictor of clinical outcome in cancer patients. Hum Pathol. 2000;31(4):403–405
  25. Wei MX, Bougnoux P, Sacre-Salem B, et al.  Suicide gene therapy of chemically induced mammary tumor in rat (Efficacy and distant bystander effect). Cancer Res. 1998;58(16):3529–3532

PII: S0301-5629(02)00478-7

Ultrasound in Medicine and Biology
Volume 28, Issue 4 , Pages 431-437 , April 2002

Article Tools

* Image Usage & Resolution