Changes in Hemocoagulation in Acute Stroke Patients After One-Hour Sono-Thrombolysis Using a Diagnostic Probe
Received 1 December 2009; received in revised form 26 March 2010; accepted 16 April 2010.
Abstract
The aim was to monitor the changes in hemocoagulation parameters in acute ischemic stroke (AIS) patients after sono-thrombolysis of the occluded middle cerebral artery using a duplex transcranial probe with 2.0-MHz frequency in Doppler mode. Sixteen AIS patients indicated for intravenous thrombolysis (IVT) (8 males; mean age 68.3 ± 7.1 y) and 16 AIS patients contraindicated for IVT (11 males; mean age 67.9 ± 7.9 y) were randomized for sono-thrombolysis (8 + 8 patients) or standard treatment (control group) (8 + 8 patients). The significant decrease of plasminogen activator inhibitor-1, plasminogen and α-2-antiplasmin activity by a mean of 60, 32 and 24%, respectively, and the increase of tissue plasminogen activator by a mean of 56% was found after sono-thrombolysis when compared with control group (p < 0.0125); these changes were more evident in patients treated with a combination of sono-thrombolysis and IVT (79, 38, 50 and 82%, respectively) than in patients treated by sono-thrombolysis alone (34, 13, 17 and 30%, respectively). (E-mail: skoloudik@hotmail.com)
∗Department of Neurology, University Hospital, Ostrava, Czech Republic
†Department of Clinical Hematology, University Children's Hospital Brno, Czech Republic
‡Department of Biometry, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic
§Department of Neurology, Hospital Třinec-Sosna, Třinec, Czech Republic
¶Stroke Center, Department of Neurology, Faculty of Medicine and Dentistry, Palacký University and University Hospital, Olomouc, Czech Republic
Address correspondence to: Assoc. Prof. David Školoudík, MD, PhD, Stroke Center, Department of Neurology, Faculty of Medicine and Dentistry, Palacký University and University Hospital, I. P. Pavlova 6, CZ-77520 Olomouc, Czech Republic.
ABSTRACT